초록 ▼

A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N′-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styre

A heterogeneous interpenetrating polymer network is provided for use in the controlled release of drugs. The network is a heterogeneous matrix that is formed from a hydrophilic component such as polyethylene oxide or poly(N,N′-dimethyl acrylamide-co-styrene) and a hydrophobic component such as styrene, an alkyl methacrylate, or polytetramethylene ether glycol. The relative amounts of the two components, or “domains”, can be varied, as can the diffusivities and solubilities of the drug combinations to be loaded therein, to control and change as desired the timed release profile of incorporated drug. Prolonged pseudo-zero order release can be obtained where one domain acts as a diffusion barrier layer to the release of drug from the other domain.

대표청구항 ▼

A three-dimensional interpenetrating polymer network (IPN) for the substantially continuous release of a drug contained therein, comprising: (a) a continuous matrix of a first, crosslinked polymeric material; (b) localized regions of a second, crosslinked polymeric material dispersed throughout said

A three-dimensional interpenetrating polymer network (IPN) for the substantially continuous release of a drug contained therein, comprising: (a) a continuous matrix of a first, crosslinked polymeric material; (b) localized regions of a second, crosslinked polymeric material dispersed throughout said matrix, wherein one of said polymeric materials is hydrophilic and the other of said materials is hydrophobic; and (c) a drug either dissolved or dispersed in one or both of said polymeric materials.