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특허 상세정보

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내보내기 페이스북 공유 카카오톡 공유

Thermal-assisted electrospray interface (TAESI) for LC/MS

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) H01J-049/10   
미국특허분류(USC) 250/288 ; 250/281 ; 250/282
출원번호 US-0202768 (1988-06-03)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 88  인용 특허 : 4
초록
▼

A Thermal-Assisted Electrospray Interface (TAESI) used in series between a liquid chromatograph and a mass analyzer gives increased sensitivity for detection of components in a liquid stream at high flow rates up to 2 milliliters per minute. Liquid exiting the liquid chromatograph is sprayed through a stainless steel capillary tube while being heated externally and under an applied voltage of about 3 KV. The combination of thermal energy and electric field potential disperses the liquid into a fine mist which is then directed at atmospheric pressure into...

대표
청구항
▼

Apparatus for forming ions at atmospheric pressure from trace sample molecules in a liquid and for introducing said ions into a mass analyzer, comprising: (a) a chamber, (b) a conductive capillary tube to receive said liquid and having a first free end within said chamber, (c) a thermal energy means for heating the liquid in the tube said thermal energy means extending substantially the length of the tube within the chamber, (d) an orifice plate having an orifice therein, said tube being located on one side of said orifice plate in said chamber with said...

이 특허에 인용된 특허 (4)

  1. Tsuchiya, Masahiko; Kuwabara, Hirofumi. Apparatus for producing sample ions. USP1985104546253.
  2. Bateman Robert H. (Knutsford GB2) Jones David S. (Sale GB2). Discharge ionization mass spectrometer. USP1988124794252.
  3. Vestal Marvin L. (Houston TX) Blakley Calvin R. (Houston TX). Ion vapor source for mass spectrometry of liquids. USP1988034730111.
  4. Huffman Fred N. (Sudbury MA). Method and apparatus for producing negative ions. USP1981114298798.

이 특허를 인용한 특허 피인용횟수: 88

  1. Howell Tony M. ; Sweeney William R.. Aerosol and a method and apparatus for generating an aerosol. USP1998045743251.
  2. Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Wensley, Martin J.. Aerosol forming device for use in inhalation therapy. USP2017069687487.
  3. Gupta, Rajiv; McRae, Douglas D.; Cox, Kenneth A.; Nichols, Walter A.. Aerosol generating devices and methods for generating aerosols having controlled particle sizes. USP2010067743766.
  4. Wensley, Martin J.; Mufson, Daniel; Hodges, Craig C.; Lloyd, Peter M.; Rogers, Daniel D.. Aerosol generating method and device. USP2016049308208.
  5. Wensley, Martin J.; Mufson, Daniel; Hodges, Craig C.; Lloyd, Peter M.; Rogers, Daniel D.. Aerosol generating method and device. USP2010087766013.
  6. Cox Kenneth A. ; Beane Timothy Paul ; Sweeney William R.. Aerosol generator and methods of making and using an aerosol generator. USP2001056234167.
  7. Cox, Kenneth A.; Beane, Timothy Paul; Sweeney, William R.. Aerosol generator and methods of making and using an aerosol generator. USP2003056557552.
  8. Cox, Kenneth A.; Beane, Timothy Paul; Sweeney, William R.; Nichols, Walter A.; Sprinkel, Jr., F. Murphy. Aerosol generator and methods of making and using an aerosol generator. USP2003026516796.
  9. Cox,Kenneth A.; Beane,Timothy Paul; Sweeney,William R.; Nichols,Walter A.; Sprinkel, Jr.,F. Murphy. Aerosol generator and methods of making and using an aerosol generator. USP2006107117867.
  10. Sprinkel, Jr., F. Murphy; Nichols, Walter A.. Aerosol generator having a multiple path heater arrangement and method of use thereof. USP2004016681769.
  11. Sherwood, Timothy S.; Sowers, Scott A.; Reddy, Sirisha P.; Sprinkel, Jr., F. Murphy; Cox, Kenneth A.; Nichols, Walter A.. Aerosol generator having heater arranged to vaporize fluid in fluid passage between bonded layers of laminate. USP2004106804458.
  12. Sprinkel, Jr., F. Murphy; Nichols, Walter A.; Cox, Kenneth A.; Sherwood, Timothy S.; Sowers, Scott A.; Washington, Zelita R.; Reddy, Sirisha. Aerosol generator having heater in multilayered composite and method of use thereof. USP2004036701921.
  13. Sharpe, David E.; Felter, John L.. Aerosol generator having inductive heater and method of use thereof. USP2004016681998.
  14. Kenneth A. Cox ; Walter A. Nichols ; F. Murphy Sprinkel, Jr. ; Douglas D. McRae ; William R. Sweeney. Aerosol generator having multiple heating zones and methods of use thereof. USP2002126501052.
  15. Cox,Kenneth A.; Nichols,Walter A.; Sprinkel, Jr.,F. Murphy; McRae,Douglas D.; Sweeney,William R.. Aerosol generator having temperature controlled heating zone and method of use thereof. USP2007027173222.
  16. Begg Geoffrey Stephen,AUX ; Simpson Richard John,AUX ; Burgess Antony Wilks,AUX. Apparatus allowing sequential chemical reactions. USP1998125853668.
  17. Loucks ; Jr. Harvey D. ; Fischer Steven M. ; Gourley Darrell L.. Apparatus for forming liquid droplets having a mechanically fixed inner microtube. USP1999025868322.
  18. Kato,Yoshiaki. Atmospheric pressure ionization mass spectrometer system. USP2006077081620.
  19. Yang,Zicheng; Tong,Roger C.. Atmospheric pressure ionization with optimized drying gas flow. USP2006127145136.
  20. Scalf, Mark A.; Smith, Lloyd M.; Westphall, Michael S.; Ebeling, Daniel D.. Charge reduction in electrospray mass spectrometry. USP2004046727497.
  21. Berggren, William Travis; Westphall, Michael Scott; Smith, Lloyd Michael. Charged particle source with droplet control for mass spectrometry. USP2005066906322.
  22. Szalay, Daniel; Godorhazy, Lajos; Takats, Zoltan. Collision ion generator and separator. USP20190310242858.
  23. Szalay, Daniel; Godorhazy, Lajos; Takats, Zoltan. Collision ion generator and separator. USP2016039287100.
  24. Sampath, Rangarajan; Hall, Thomas A.; Ecker, David J.; Blyn, Lawrence. Compositions for use in identification of bacteria. USP2011098013142.
  25. Hirabayashi, Atsumu; Huang, Min; Hirabayashi, Yukiko; Okumura, Akihiko. DNA analysis system. USP2004016673547.
  26. Pringle, Steven Derek; Morris, Michael Raymond; Smith, Stephen; McCullagh, Michael. Diathermy knife ionisation source. USP2018049947524.
  27. Pringle, Steven Derek; Morris, Michael Raymond; Smith, Stephen; McCullagh, Michael. Diathermy knife ionisation source. USP2015069053914.
  28. Nichols, Walter A.; Sprinkel, Jr., F. Murphy. Disposable aerosol generator system and methods for administering the aerosol. USP2004106799572.
  29. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy. Disposable aerosol generator system and methods for administering the aerosol. USP2008057373938.
  30. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy. Disposable inhaler system. USP2006077077130.
  31. Nichols,Walter A.; Sprinkel, Jr.,F. Murphy. Disposable inhaler system. USP2007017163014.
  32. Nichols, Walter A.; Cox, Kenneth A.; Nguyen, Tung Tien. Dual capillary fluid vaporizing device. USP2004046715487.
  33. Nichols, Walter A.; Cox, Kenneth A.; Nguyen, Tung Tien. Dual capillary fluid vaporizing device. USP2003056568390.
  34. Tak찼ts,Zolt찼n; Cooks,Robert G.. Electrosonic spray ionization method and device for the atmospheric ionization of molecules. USP2006037015466.
  35. Sheehan Edward W. ; Willoughby Ross C. ; Jarrell Joseph A. ; Strand David M.. Electrospray for chemical analysis. USP2001086278111.
  36. Thakur,Rohan A.. Electrospray ion source apparatus. USP2007047199364.
  37. Frey, Brian L.; Smith, Lloyd M.; Westphall, Michael S.. Electrospray ionization ion source with tunable charge reduction. USP2009047518108.
  38. Faison, Jr.,Gene G.; Gupta,Rajiv; McRae,Douglas D.; Nichols,Walter A.. Fluid vaporizing device having controlled temperature profile heater/capillary tube. USP2008057367334.
  39. Nichols, Walter A.; Cox, Kenneth A.; McRae, Douglas D.; Nguyen, Tung Tien. Fluid vaporizing device having controlled temperature profile heater/capillary tube. USP2003106640050.
  40. Galauner, Charles; Menn, Gregory; Nelson, Richard A.; Avery, Hazelton P.; Purkis, Timothy E.; Faje, Richard A.; Timmons, Ryan D.; Kelly, Andrew J.G.; Wensley, Martin J.. Heating element connector assembly with insert molded strips. USP2009047513781.
  41. Galauner,Charles; Menn,Gregory; Nelson,Richard A.; Avery,Hazelton P.; Purkis,Timothy E.; Faje,Richard A.. Heating element connector assembly with press-fit terminals. USP2009027494344.
  42. Jolliffe, Charles. High intensity ion source apparatus for mass spectrometry. USP2003076586731.
  43. Belcastro, Marc D.; Swepston, Jeffrey A.. Indirectly heated capillary aerosol generator. USP2017059642975.
  44. Belcastro, Marc D; Swepston, Jeffrey A. Indirectly heated capillary aerosoll generator. USP20190210194698.
  45. Westphall,Michael S.; Smith,Lloyd M.. Inductive detection for mass spectrometry. USP2006077078679.
  46. Atsumu Hirabayashi JP; Minoru Sakairi JP; Yasuaki Takada JP; Hideaki Koizumi JP; Kaoru Umemura JP. Ion source and mass spectrometer instrument using the same. USP2002056384411.
  47. Hirabayashi Atsumu,JPX ; Sakairi Minoru,JPX ; Takada Yasuaki,JPX ; Koizumi Hideaki,JPX ; Umemura Kaoru,JPX. Ion source and mass spectrometer instrument using the same. USP2000116147347.
  48. Hirabayashi, Atsumu; Sakairi, Minoru; Takada, Yasuaki; Koizumi, Hideaki; Umemura, Kaoru. Ion source and mass spectrometer instrument using the same. USP2010017645983.
  49. Mordehai, Alexander; Werlich, Mark H.; Love, Craig P.; Bertsch, James L.. Ion sources for improved ionization. USP2013098530832.
  50. Mordehai, Alexander; Werlich, Mark H; Love, Craig P; Bertsch, James L.. Ion sources for improved ionization. USP2011108039795.
  51. Xian-Wei Yao. Liquid transportation system for microfluidic device. USP2002046368562.
  52. Mimura Tadao (Katsuta JPX) Kato Yoshiaki (Mito JPX) Matsumura Kazumi (Naka-gun JPX). Mass spectrometer. USP1996105567938.
  53. Hirabayashi Atsumu,JPX ; Hirabayashi Yukiko,JPX ; Sakairi Minoru,JPX ; Takada Yasuaki,JPX ; Nabeshima Takayuki,JPX ; Koizumi Hideaki,JPX. Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution. USP2000096114693.
  54. Hirabayashi Atsumu,JPX ; Hirabayashi Yukiko,JPX ; Sakairi Minoru,JPX ; Takada Yasuaki,JPX ; Nabeshima Takayuki,JPX ; Koizumi Hideaki,JPX. Mass spectrometer and mass spectrometry method for analyzing compounds contained in a solution. USP1999045898175.
  55. Douglas Donald J.,CAX ; Konermann Lars,CAX ; Collings Bruce,CAX. Method and apparatus for determining the rates of reactions in liquids by mass spectrometry. USP2000046054709.
  56. Valaskovic, Gary A.; Lee, Mike S.. Method and apparatus for feedback controlled electrospray. USP2004066744046.
  57. Byron,Peter R.; Hindle,Michael. Method and apparatus for generating an aerosol. USP2006107128067.
  58. Hale, Ron L.; Song, Soonho; Quintana, Reynaldo J.; Rabinowitz, Joshua D.; Zaffaroni, Alejandro C.. Method and apparatus for vaporizing a compound. USP2011087987846.
  59. Hale,Ron L.; Song,Soonho; Quintana,Reynaldo J.; Zaffaroni,Alejandro C.; Rabinowitz,Joshua D.. Method and apparatus for vaporizing a compound. USP2008127458374.
  60. Eriksson, Johan. Method and device for electrospray ionization. USP2004016683302.
  61. Takats, Zoltan. Method and device for in vivo desorption ionization of biological tissue. USP2017079709529.
  62. Krutchinsky, Andrew; Cohen, Herbert; Kalkum, Markus; Sherman, Vadim; Chait, Brian. Method and system for mass spectroscopy. USP2003096617577.
  63. Valaskovic, Gary A.; Lee, Mike S.. Method for feedback controlled electrospray. USP2005126977372.
  64. Hindle, Michael; Byron, Peter R.; Gupta, Rajiv. Method for generating an aerosol with a predetermined and/or substantially monodispersed particle size distribution. USP2005046883516.
  65. Sproch,Norman K.. Method for the characterization of the three-dimensional structure of proteins employing mass spectrometric analysis and computational feedback modeling. USP2006057047171.
  66. Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Song, Soonho; Wensley, Martin J.; Myers, Daniel J.; McKinney, Jeffrey A.; Quintana, Reynaldo J.; Rabinowitz, Joshua D.. Method of forming an aerosol for inhalation delivery. USP2016099439907.
  67. Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Song, Soonho; Wensley, Martin J.; Myers, Daniel J.; McKinney, Jeffrey A.; Quintana, Reynaldo J.; Rabinowitz, Joshua D.. Method of forming an aerosol for inhalation delivery. USP2009057537009.
  68. Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Song, Soonho; Wensley, Martin J.; Myers, Daniel J.; McKinney, Jeffrey A.; Quintana, Reynaldo J.; Rabinowitz, Joshua D.. Method of forming an aerosol for inhalation delivery. USP2011128074644.
  69. Hale, Ron L.; Hodges, Craig C.; Lloyd, Peter M.; Mufson, Daniel; Rogers, Daniel D.; Song, Soonho; Wensley, Martin J.; Myers, Daniel J.; McKinney, Jeffrey A.; Quintana, Reynaldo J.; Rabinowitz, Joshua D.. Method of forming an aerosol for inhalation delivery. USP2015028955512.
  70. ？hman,Per Ove; Andersson,Per. Method of manufacturing a microscale nozzle. USP2007057213339.
  71. Krutchinsky, Andrew; Cohen, Herbert; Kalkum, Markus; Sherman, Vadim; Chait, Brian. Method of transmitting ions for mass spectroscopy. USP2004106809318.
  72. Hall, Thomas A.; Sampath, Rangarajan; Harpin, Vanessa; Hofstadler, Steven A.; Jiang, Yun. Methods for identification of sepsis-causing bacteria. USP2012018097416.
  73. Hall, Thomas A.; Sampath, Rangarajan; Harpin, Vanessa; Hofstadler, Steven A.; Jiang, Yun. Methods for identification of sepsis-causing bacteria. USP2013108546082.
  74. Hindle, Michael; Byron, Peter R.; Hong, John N.. Mouthpiece entrainment airflow control for aerosol generators. USP2004036701922.
  75. Cross, Stephen D.; Herbette, Mathieu; Kelly, Andrew J. G.; Myers, Daniel J.; Shen, William W.; Timmons, Ryan D.; Tom, Curtis; Virgili, Justin M.; Wensley, Martin J.. Multiple dose condensation aerosol devices and methods of forming condensation aerosols. USP2012128333197.
  76. Cross, Steven D.; Herbette, Mathieu; Kelly, Andrew J. G.; Myers, Daniel J.; Shen, William W.; Timmons, Ryan D.; Tom, Curtis; Virgili, Justin M.; Wensley, Martin J.. Multiple dose condensation aerosol devices and methods of forming condensation aerosols. USP2009067540286.
  77. Dale R. Pfost ; Sheila H. DeWitt ; Chao Lin ; Rolf E. Swenson ; Robert D. Juncosa ; Gary J. Schnerr ; Sheldon M. Kugelmass. Multiple fluid sample processor and system. USP2002116485690.
  78. Apffel ; Jr. James A. ; Werlich Mark H. ; Bertsch James L. ; Goodley Paul C. ; Henry Kent D.. Orthogonal ion sampling for electrospray .[.LC/MS.]. mass spectrometry. USP200010RE36892.
  79. Berggren, William Travis; Westphall, Michael Scott; Scalf, Mark Andrew; Smith, Lloyd Michael. Piezoelectric charged droplet source. USP2004096797945.
  80. Schuermann,Max C.; Seher,Bernd; Mueller,Lutz; Missalla,Thomas. Plasma radiation source and device for creating a gas curtain for plasma radiation sources. USP2008027328885.
  81. Hale, Ron L.; Lloyd, Peter M.; Lu, Amy; Myers, Daniel J.; Quintana, Reynaldo J.; Rabinowitz, Joshua D.; Solas, Dennis W.; Song, Soonho; Tom, Curtis; Wensley, Martin J.. Rapid-heating drug delivery article and method of use. USP2010017645442.
  82. Karger Barry L. ; Foret Frantisek ; Kirby Daniel P.. Subatmospheric, variable pressure sample delivery chamber for electrospray ionization/mass spectrometry and other applications. USP2000056068749.
  83. Takats, Zoltan. System and method for identification of biological tissues. USP2015069046448.
  84. Takats, Zoltan. System and method for rapid evaporative ionization of liquid phase samples. USP2017109805922.
  85. Takats, Zoltan. System and method for rapid evaporative ionization of liquid phase samples. USP2016039281174.
  86. Hofstadler,Steven A.; Drader,Jared J.; Sannes Lowery,Kristin A.; Griffey,Richard H.. Systems and method of a gated electrospray interface with variable flow rate for high throughput mass spectrometric analysis. USP2006087095017.
  87. Hale, Ron L.; Lu, Amy; Myers, Daniel J.; Rabinowitz, Joshua D.; Wensley, Martin J.. Thin-film drug delivery article and method of use. USP2009097585493.
  88. Walter A. Nichols. Vapor driven aerosol generator and method of use thereof. USP2002126491233.

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