초록 ▼

A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a

A biodegradable polymer is provided for use in providing syringeable, in-situ forming, solid biodegradable implants for animals. The polymer is placed into the animal in liquid form and cures to form the implant in-situ. A thermoplastic system to form said implant comprises the steps of dissolving a non-reactive polymer in biocompatible solvent to form a liquid, placing the liquid within the animal, and allowing the solvent to dissipate to produce the implant. An alternative, thermosetting system comprises mixing together effective amounts of a liquid acrylic ester terminated, biodegradable prepolymer and a curing agent, placing the liquid mixture within an animal and allowing the prepolymer to cure to form the implant. Both systems provide a syringeable, solid biodegradable delivery system by the addition of an effective level of biologically active agent to the liquid before injection into the body.

대표청구항 ▼

A method of forming an implant in-situ, in a living body, comprising the steps of: (a) dissolving a non-reactive, water-insoluble polymer in a biocompatible, water-soluble solvent to form a liquid; (b) placing said liquid within said body; and (c) allowing said solvent to dissipate to produce a soli

A method of forming an implant in-situ, in a living body, comprising the steps of: (a) dissolving a non-reactive, water-insoluble polymer in a biocompatible, water-soluble solvent to form a liquid; (b) placing said liquid within said body; and (c) allowing said solvent to dissipate to produce a solid implant.