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Pharmaceutical compositions and methods of treatment to prevent and treat corneal scar formation produced by laser irrad 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/56
출원번호 US-0253009 (1988-10-03)
발명자 / 주소
  • Robertson Stella M. (Arlington TX) Kunkle
  • Jr. Herman M. (Mansfield TX) Stern Michael E. (Grapevine TX)
출원인 / 주소
  • Alcon Laboratories, Inc. (Fort Worth TX 02)
인용정보 피인용 횟수 : 20  인용 특허 : 12

초록

Methods for preventing and treating corneal haze resulting from exposure of the eye to laser irradiation are disclosed. The methods include administration of compositions of wound healing modulators to the eye. Compositions for use in preventing and treating the corneal haze are also disclosed.

대표청구항

A method for treating corneal haze as an artifact of incident UV laser irradiation and resulting photoablation of corneal tissue comprising: applying topically to the affected eye, a therapeutically effective amount of a steroid.

이 특허에 인용된 특허 (12)

  1. York ; Jr. Billie M. (Fort Worth TX), Aldose reductase inhibitors useful in ophthalmic wound healing.
  2. Woods Gilbert Frederick (Glasgow SC) Cairns James (Cumbernauld SC) McGarry George (Airdrie SC), Alkylated 3,20-diketo-D4-steroids of the pregnane series.
  3. Boltralik John J. (Fort Worth TX), Anti-inflammatory compounds for ophthalmic use.
  4. Gnzler Volkmar (Bodenheim DEX) Hanauske-Abel Hartmut (Dexheim DEX) Mohr Jrgen (Bischofsheim DEX) Tschank Georg (Mainz DEX) Kivirikko Kari (Oulu CA FIX) Majamaa Kari (San Pedro CA) Brocks Dietrich (Hn, Esters of pyridine-2,4- and 2,5-dicarboxylic acid as medicaments for the inhibition of proline hydroxylase and lysine hy.
  5. L\Esperance ; Jr. Francis A. (Englewood NJ), Method for ophthalmological surgery.
  6. L\Esperance ; Jr. Francis A. (Englewood NJ), Method for performing ophthalmic laser surgery.
  7. York ; Jr. Billie M. (Fort Worth TX), Method of inhibiting aldose reductase activity.
  8. Han, Wesley W.; Roehrs, Robert E., Nonirritating aqueous ophthalmic compositions comfort formulation for ocular therapeutic agents.
  9. Haslam John L. (Lawrence KS) Higuchi Takeru (Lawrence KS) Mlodozeniec Arthur R. (Lawrence KS), Ophthalmic drug delivery system utilizing thermosetting gels.
  10. York ; Jr. Billie M. (Fort Worth TX), Ophthalmic wound healing with aldose reductase inhibitors.
  11. York ; Jr. Billie M. (Fort Worth TX), Spiro-(fluoren-9,4′-imidazolidine)-2′,5′-diones.
  12. Waterbury L. David (San Mateo CA), Use of pyrrolo pyrroles in treatment of ophthalmic diseases.

이 특허를 인용한 특허 (20)

  1. Thomas, Paul Eugene; Marsh, Thomas Patrick, Acquisition distribution layer having void volumes for an absorbent article.
  2. Thomas, Paul Eugene; Marsh, Thomas Patrick, Acquisition distribution layer having void volumes for an absorbent article.
  3. Thomas,Paul Eugene; Marsh,Thomas Patrick, Acquisition distribution layer having void volumes for an absorbent article.
  4. Lee Clarence C. (Lilburn GA), Composition and method for revitalizing scar tissue.
  5. Yeh Kuo-Chen (Westfield NJ) Sena Frank J. (Brooklyn NY) Alfano Michael C. (Franklin Lakes NJ), Compositions and method for the treatment of disease.
  6. Cejkova Jitka (102 11 Praha 10 V Novem Hostivati 21 CSX) Vacik Jiri (140 00 Praha 4 Mechanicka 18/2560 CSX), Contact lens of hydrophilic gels with inhibitor and swelling agent.
  7. Schultz, Clyde L.; Schentag, Jerome J., Device and method for the delivery of drugs for the treatment of posterior segment disease.
  8. Schultz, Clyde L., Growth factor delivery system for the healing of wounds and the prevention of inflammation and disease.
  9. Schultz,Clyde L., Growth factor delivery systems for the healing of wounds and the prevention of inflammation and disease.
  10. Beaulieu, Andre; Paquin, Robert, Method of producing concentrated non-buffered solutions of fibronectin.
  11. Wooley, Richard E.; Ritchie, Branson W.; Kemp, Douglas T.; Capomacchia, Anthony C.; Burnley, Victoria V., Methods and compositions for promoting wound healing.
  12. Wooley, Richard E.; Ritchie, Branson W.; Kemp, Douglas T.; Capomacchia, Anthony C.; Burnley, Victoria V., Methods and compositions for promoting wound healing.
  13. Matsumoto, Eri; Nishina, Yasuko; Haruna, Kenichi; Arita, Harumasa; Kita, Akiko, Ophthalmic composition containing alginic acid or salt thereof.
  14. Dennis E. Hallahan ; Ralph R. Weichselbaum ; Donald W. Kufe, Phospholipase A2 inhibitors as mediators of gene expression.
  15. Beaulieu,Andre; Paquin,Robert; Lariviere,Benoit, Solid wound healing formulations containing fibronectin.
  16. Amar, Lulla; Malhotra, Geena, Sterilization process.
  17. Gamache Daniel A., Topical use of .kappa. opioid agonists to treat ocular pain.
  18. Gadd, Martha E.; David, Karen C., Use of FAAH antagonists for treating dry eye and ocular pain.
  19. Timothy L. Kessler ; Jon C. Nixon ; Karen C. David ; Gustav Graff, Use of inhibitors of gag synthesis for the treatment of corneal haze.
  20. Stern Michael E. ; Wheeler Larry A. ; Nicolson Margery A., Use of platelet derived growth factor in ophthalmic wound healing.

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