초록 ▼

An arrangement is provided for the application of an oral pharmaceutical to the mucosa of the oral or nasal cavity, for sustained release there of the drug. The arrangement of the invention comprises a body which has a size and shape suitable for insertion into and retention in the oral or nasal cav

An arrangement is provided for the application of an oral pharmaceutical to the mucosa of the oral or nasal cavity, for sustained release there of the drug. The arrangement of the invention comprises a body which has a size and shape suitable for insertion into and retention in the oral or nasal cavity, the body being formed of granules of a higher aliphatic alcohol and a hydrated water soluble hydroxyalkyl cellulose having the drug distributed therethrough. This body is coated with a cellulose derivative which is adherent to the mucosa. As a consequence, upon insertion into the oral or nasal cavity, the body adheres to the mucosa and the drug is there slowly released and absorbed into the body. The arrangement is preferably in the form of a buccal tablet, particularly a kidney shaped buccal tablet. Any drug suitable for oral administration can be used, morphine being preferred. The cellulose derivative which is preferred is hydroxypropyl cellulose. The higher aliphatic alcohol is preferably cetostearyl alcohol, and the water soluble cellulose is preferably hydroxyethyl cellulose.

대표청구항 ▼

Arrangement adapted for application and adherence to the mucosa of the oral or nasal cavity for sustained release there of an orally administerable drug, said arrangement comprising a body having an orally administerable drug distributed therein and having a size and shape suitable for insertion int

Arrangement adapted for application and adherence to the mucosa of the oral or nasal cavity for sustained release there of an orally administerable drug, said arrangement comprising a body having an orally administerable drug distributed therein and having a size and shape suitable for insertion into and retention in the oral or nasal cavity, said body being formed of granules of a higher aliphatic alcohol of 8-18 carbon atoms and a hydrated water soluble hydroxyloweralkyl cellulose having said drug distributed therethrough and being coated with a cellulose derivative which is adherent to the mucosa, whereby upon insertion into the oral or nasal cavity said body adheres to the mucosa thereof and the drug is there slowly released and absorbed.