초록 ▼

Electrofusion of biological particles to specific areas of tissue is accomplished in vivo through the use of electrode members that conform to the configuration and dimension of the tissue at the electrofusion site. The electrode members are positioned in close physical proximity to one another so t

Electrofusion of biological particles to specific areas of tissue is accomplished in vivo through the use of electrode members that conform to the configuration and dimension of the tissue at the electrofusion site. The electrode members are positioned in close physical proximity to one another so that when an electrical potential difference is established between them, current flow is limited to the area of tissue between the electrodes so that tissue remote from the selected electrofusion site is substantially unaffected by such current flow. A general apparatus and method is supplemented with two illustrative apparatus and methods for accomplishing in vivo electrofusion on corneas and in cervical areas.

대표청구항 ▼

A device for confining flow of electrons through living tissue to a preselected area of said tissue, comprising: a first electrode means adapted to be disposed in abutting relation to a first preselected area of tissue; a second electrode means, generally annular in configuration, adapted to be disp

A device for confining flow of electrons through living tissue to a preselected area of said tissue, comprising: a first electrode means adapted to be disposed in abutting relation to a first preselected area of tissue; a second electrode means, generally annular in configuration, adapted to be disposed in abutting relation to a second preselected area of tissue having a generally spherical shape, said second preselected area of tissue being in closely spaced proximity to said first preselected area of tissue; a source of electrical power; means for electrically coupling said source of electrical power to said first electrode means; and means for grounding said second electrode means; whereby in vivo electrofusion occurs at the interface of said first preselected area of tissue and said first electrode means.