초록

A process is described for extracting a pharmaceutically active polysaccharidic substance from the aloe plant. The pharmaceutically active polysaccharidic substance and its characteristic properties are described.

대표청구항 ▼

Process for extracting from the aloe plant a substantially non-degradable lypholized polymer of linear b1→4)-D-mannosyl units wherein randomly interspersed acetyl groups are linked to the polymer through an oxygen atom and wherein D-galactopyranose is linked to the polymer through an a2-6) linkage a

Process for extracting from the aloe plant a substantially non-degradable lypholized polymer of linear b1→4)-D-mannosyl units wherein randomly interspersed acetyl groups are linked to the polymer through an oxygen atom and wherein D-galactopyranose is linked to the polymer through an a2-6) linkage at a ratio of about one D-galactopyranose residue per seventy monomer units, comprising: (a) washing an aloe leaf in a bacteriacidal solution to remove substantially all surface dirt and bacteria; (b) removing at lest a first end portion from said washed leaf; (c) removing rind and any remaining anthraquinone-rich sap from said leaf to produce a substantially anthraquinone-free aloe gel fillet; (d) grinding and homogenizing said substantially anthraquinone-free aloe gel to produce substantially anthraquinone-free aloe juice having solubilized matter; (e) filtering said ground and homogenized aloe juice to remove fibrous material; (f) adjusting the pH of said aloe juice of from about 3.00 to about 3.50; (g) adding a water-soluble, lower aliphatic polar solvent to the aloe juice to precipitate the active chemical substance and thereby to form a heterogeneous solution containing soluble contaminants; (h) removing the water soluble, lower aliphatic polar solvent and the solubilized matter from the heterogeneous solution to isolate the precipitated active chemical substance; and (i) drying the precipitated active chemical substance.