초록

Process for producing an antibody catalyst for a chemical reaction. Chemical reactions in which the antibody catalyst can be used are also disclosed.

대표청구항 ▼

Process for producing an antibody catalyst for a chemical reaction, which comprises: (1) identifying a substrate for said chemical reaction, said substrate represented by formula R1－X－R2; (2) selecting a hapten which corresponds to said substrate, said hapten represented by formula [Figure] wherein

Process for producing an antibody catalyst for a chemical reaction, which comprises: (1) identifying a substrate for said chemical reaction, said substrate represented by formula R1－X－R2; (2) selecting a hapten which corresponds to said substrate, said hapten represented by formula [Figure] wherein X represents one or more nuclei and associated bonds which contain O, S, N or C and which comprise the portion of the substrate molecule to be altered in the chemical reaction and Y represents one or more nuclei and associated bonds which contain N, C or P and which comprises the portion of the hapten molecule corresponding to the portion of the substrate molecule to be altered in the chemical reaction and wherein Y is related to X such that Y has a higher valence state and one or more bonds than X, and wherein Q represents one or more substituents selected from the group consisting of (a) positively charged substituents, (b) negatively charged substituents, (c) polar substituents, (d) non-polar substituents, and (e) substituents of substantial bulk, and wherein Q can contain a group capable of linking the hapten to the carrier, and wherein R1, R2, R1′and R2′represent the residual chemical groups of the substrate and hapten which do not participate in catalytic events, and R1 and R1′, and R2 and R2′are, respectively, substantially similar to each other; (3) stimulating an immune response to said hapten and (4) isolating antibodies resulting from said immune response which antibodies are catalytically active for said chemical reaction.