초록 ▼

This invention relates to a biodegradable collagen matrix having a pore size and morphology which enhances the healing of a wound. It further relates to a process for preparing the matrix. One embodiment of the invention comprises a biodegradable matrix which comprises collagen, hyaluronic acid and

This invention relates to a biodegradable collagen matrix having a pore size and morphology which enhances the healing of a wound. It further relates to a process for preparing the matrix. One embodiment of the invention comprises a biodegradable matrix which comprises collagen, hyaluronic acid and fibronectin. Other embodiments include a process which comprises freeze drying a dispersion containing collagen, crosslinking the collagen via two crosslinking steps and freeze drying the crosslinked matrix.

대표청구항 ▼

A biodegradable, porous, collagen-based sponge-like composition, especially useful for the treatment of skin wounds, which comprises a biodegradable, three-dimensional matrix of carbodiimide and dehydrothermal cross-linked collagen fibers, wherein the fibers define randomly distributed surface and i

A biodegradable, porous, collagen-based sponge-like composition, especially useful for the treatment of skin wounds, which comprises a biodegradable, three-dimensional matrix of carbodiimide and dehydrothermal cross-linked collagen fibers, wherein the fibers define randomly distributed surface and interior pores which are connected by channels within the iunterior of the sponge, and the channels connect the surface of the composition with the interior of the sponge-like composition, the average pore size being from about 50 to about 250 um, which collagen-based sponge like composition promotes the healing of wounds by fibroblast movement into the channels and pores, attachment of the collagen inside the channels and new tissue formation in the wound.