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Microcrystals comprising an active substance having an affinity for phospholipids, and at least one phospholipid, proces 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-025/32
출원번호 US-0364481 (1989-06-08)
우선권정보 FR-0017116 (1986-12-05); FR-0002137 (1987-02-19); FR-0012424 (1987-09-08)
발명자 / 주소
  • Baurain Roger (Wezembeek BEX) Trouet Andre B. L. (Winksele BEX)
출원인 / 주소
  • Ire-Celltarg S.A. (Fleurus BEX 03)
인용정보 피인용 횟수 : 51  인용 특허 : 4

초록 ▼

The present invention relates to microcrystals of a substance, which substance is insoluble in water and has an affinity for phospholipids, as well as a process for its preparation. According to the invention, one or more organic solvents are evaporated from a solution of phospholipids and substance

대표청구항 ▼

Process for the preparation of lipidic microparticles of an active substance and at least one phospholipid, the microparticles having a crystalline appearance and being stable in suspension in aqueous solution, said process comprising the steps of: providing a solution of a phospholipid and an activ

이 특허에 인용된 특허 (4)

  1. Haga Takahiro (Kusatsu JPX) Yamada Nobutoshi (Moriyama JPX) Sugi Hideo (Moriyama JPX) Koyanagi Toru (Kyoto JPX) Kondo Nobuo (Daito JPX) Nakajima Tsunetaka (Kashiwara JPX) Watanabe Masahiro (Akashi JP, Benzoyl urea compounds, process for their production, and antitumorous compositions containing them.
    상세보기
  2. Mizushima Yutaka (Tokyo JPX) Fujii Mitsuharu (Shiga JPX) Takei Hiroshi (Showa JPX), Pharmaceutical oil-in-water type micro-emulsion.
    상세보기
  3. Riedl Zoltan (Budapest HUX) Sztankov Laszlo (Szentendre HUX) Horvath Istvan (Budapest HUX), Process for preparing lipoid-biologically active particles.
    상세보기
  4. Fukushima Tsunekazu (Hyogo JPX) Emoto Hiroshi (Osaka JPX) Kagitani Yoshio (Nara JPX) Yokoyama Kazumasa (Osaka JPX) Nishida Masayuki (Osaka JPX) Suyama Tadakazu (Kyoto JPX), Water soluble drug complex and method for production of same.
    상세보기

이 특허를 인용한 특허 (51)

  1. Cartt, Steve; Medeiros, David; Gwozdz, Garry Thomas; Loxley, Andrew; Mitchnick, Mark; Hale, David; Maggio, Edward T., Administration of benzodiazepine compositions.
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  2. Cartt, Steve; Medeiros, David; Gwozdz, Garry Thomas; Loxley, Andrew; Mitchnick, Mark; Hale, David; Maggio, Edward T., Administration of benzodiazepine compositions.
    상세보기
  3. Parikh, Indu; Moussa, Iskandar; Carrier, Alain, Anticancer compositions.
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  4. Vachon, Michael; Awadesh, Mishra K.; Snow, Robert A.; Guivarc'H, Pol-Henri, Coated tablets.
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  5. Vachon, Michael; Awadhesh, Mishra K.; Snow, Robert A.; Guivarc'h, Pol-Henri, Coated tablets.
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  6. Tiwari, Deepak; Owoo, George; Nayak, Rekha; Burhop, Kenneth E., Colored esmolol concentrate.
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  7. Mautone Alan J., Composition and method for treatment of otitis media.
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  8. Mautone, Alan J., Composition and method for treatment of otitis media.
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  9. Beduneau, Arnaud; Gendelman, Howard; Rabinow, Barrett; Werling, Jane, Compositions and methods for drug delivery.
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  10. Kipp,James E.; Doty,Mark J.; Rebbeck,Christine L.; Brynjelsen,Sean; Konkel,Jamie Teresa, Compositions of and method for preparing stable particles in a frozen aqueous matrix.
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  11. Kipp, James E.; Rabinow, Barrett E., Ex-vivo application of solid microparticulate therapeutic agents.
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  12. Parikh,Indu, Fenofibrate microparticles.
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  13. Tarara, Thomas E.; Weers, Jeffry G.; Eldon, Michael A.; Narashimhan, Rangachari; Clark, Andrew, Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use.
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  14. Mishra,Awadhesh K.; Pace,Gary W.; Vachon,Michael G, Injectable aqueous dispersions of propofol.
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  15. Mishra,Awadhesh K.; Pace,Gary W.; Vachon,Michael G., Injectable aqueous dispersions of propofol.
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  16. Henriksen, Inge B; Mishra, Awadesh K.; Pace, Gary W.; Johnston, Keith P.; Mawson, Simon, Insoluble drug delivery.
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  17. Henriksen, Inge B; Mishra, Awadesh K.; Pace, Gary W.; Johnston, Keith P.; Mawson, Simon, Insoluble drug delivery.
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  18. Domb Abraham J. (Baltimore MD) Maniar Manoj (Baltimore MD), Liposphere delivery systems for local anesthetics.
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  19. Janoff Andrew S. (Yardley PA) Boni Lawrence (Monmouth Junction NJ) Madden Thomas D. (Vancouver CAX) Cullis Pieter R. (Vancouver CAX) Lenk Robert P. (Lambertville NJ) Kearns John J. (Princeton NJ) Dur, Low toxicity drug-lipid systems.
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  20. Lagace, Jacqueline; Beaulac, Christian; Clement-Major, Sebastien, Low-rigidity liposomal formulation.
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  21. Carpenter, Charles, Method and device for detecting analytes in fluids.
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  22. Carpenter, Charles R., Method and device for detecting analytes in fluids.
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  23. Carpenter, Charles R., Method and device for detecting analytes in fluids.
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  24. Rabinow, Barrett; Kipp, James E.; Gendelman, Howard, Method for delivering drugs to the brain.
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  25. Rabinow, Barrett E.; Gendelman, Howard E.; Kipp, James E., Method for delivering particulate drugs to tissues.
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  26. Kipp, James E.; Wong, Joseph Chung Tak; Doty, Mark J.; Werling, Jane; Rebbeck, Christine L.; Brynjelsen, Sean, Method for preparing submicron particle suspensions.
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  27. Chaubal, Mahesh; Werling, Jane; Rabinow, Barrett, Method for preparing submicron particles of antineoplastic agents.
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  28. Werling, Jane; Kipp, James E.; Sriram, Rajaram; Doty, Mark J., Method for preparing submicron suspensions with polymorph control.
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  29. Rabinow, Barrett; White, Randy; Sun, Chong-Son; Wong, Joseph Chung Take; Kipp, James E.; Doty, Mark; Rebbeck, Christine L.; Papadopoulos, Pavlos, Method for treating infectious organisms normally considered to be resistant to an antimicrobial drug.
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  30. Kelemen Robyne J. ; Durning Anthony G., Method of separating materials from liposomes or lipid complexes.
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  31. Andrew S. Janoff ; Thomas D. Madden CA; Pieter R. Cullis CA; John J. Kearns ; Anthony G. Durning, Methods of preparing low-toxicity drug-lipid complexes.
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  32. Parikh, Indu; Selvaraj, Ulagaraj, Microparticles of water-insoluble substances.
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  33. Kipp, James E.; Wong, Joseph Chung Tak; Doty, Mark J.; Rebbeck, Christine L., Microprecipitation method for preparing submicron suspensions.
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  34. Kipp, James E.; Wong, Joseph Chung Tak; Doty, Mark J.; Rebbeck, Christine L., Microprecipitation method for preparing submicron suspensions.
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  35. Kipp, James E.; Wong, Joseph Chung Tak; Doty, Mark J.; Rebbeck, Christine L.; Brynjelsen, Sean, Microprecipitation method for preparing submicron suspensions.
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  36. Kipp,James E.; Wong,Joseph Chung Tak; Doty,Mark J.; Rebbeck,Christine L., Microprecipitation method for preparing submicron suspensions.
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  37. Verhoff, Frank; Pace, Gary W.; Snow, Robert A.; Millar, Fay, Milled particles.
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  38. Tiwari, Deepak; Owoo, George; Nayak, Rekha; Burhop, Kenneth E., Multi-dose concentrate esmolol with benzyl alcohol.
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  39. Cartt, Steve; Medeiros, David; Maggio, Edward T., Multimodal particulate formulations.
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  40. Kenneth A. Larson ; William R. Campbell ; Douglas I. Hepler, Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use.
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  41. Larson Kenneth A. ; Campbell William R. ; Hepler Douglas I., Phospholipid-coated microcrystals for the sustained release of pharmacologically active compounds and methods of their manufacture and use.
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  42. Werling,Jane; Doty,Mark J.; Rebbeck,Christine L.; Wong,Joseph Chung Tak; Kipp,James E., Polymorphic form of itraconazole.
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  43. Brynjelsen, Sean; Doty, Mark; Kipp, James E.; Jayswal, Nailesh; Narayanan, Krishnaswamy, Preparation of submicron sized nanoparticles via dispersion lyophilization.
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  44. Brynjelsen, Sean; Doty, Mark; Kipp, James E.; Jayswal, Nailesh; Narayanan, Krishnaswamy, Preparation of submicron sized nanoparticles via dispersion lyophilization.
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  45. Weikert,Michael; Gordon,Marc S.; Kumar,Sandeep; Yang,Bing; Sarwar,Razaq, Pulmonary delivery of polyene antifungal agents.
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  46. de Garavilla, Lawrence; Liversidge, Elaine; Liversidge, Gary G., Reduction of intravenously administered nanoparticulate-formulation-induced adverse physiological reactions.
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  47. Westesen Kirsten,DEX ; Siekmann Britta,DEX, Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof.
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  48. Westesen Kirsten,DEX ; Siekmann Britta,DEX, Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof.
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  49. Chaubal, Mahesh; Doty, Mark J.; Konkel, Jamie T.; Rabinow, Barrett E., Surfactant systems for delivery of organic compounds.
    상세보기
  50. Mishra, Awadhesh K., Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations.
    상세보기
  51. Pace, Gary W.; Mishra, Awadesh K., Water-insoluble drug particle process.
    상세보기

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