IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0380844
(1989-07-13)
|
우선권정보 |
CH-0001117 (1987-03-24); CH-0004878 (1987-12-15) |
발명자
/ 주소 |
- Maienfisch Peter (Aesch CHX)
|
출원인 / 주소 |
- Ciba-Geigy Corporation (Ardsley NY 02)
|
인용정보 |
피인용 횟수 :
11 인용 특허 :
4 |
초록
▼
Novel 13-spiro-2′-[tetrahydrofuran]-milbemycins of the formula I [Figure] (I) in which X represents one of the groups -CH(OR1)-, -C(〓O)-or -C(〓N-OH)-; R1 represents hydrogen or a OH-protecting group; R2 represents methyl, ethyl, isopropyl or sec.-butyl or the group -C(CH3)〓CH-A in which A represents
Novel 13-spiro-2′-[tetrahydrofuran]-milbemycins of the formula I [Figure] (I) in which X represents one of the groups -CH(OR1)-, -C(〓O)-or -C(〓N-OH)-; R1 represents hydrogen or a OH-protecting group; R2 represents methyl, ethyl, isopropyl or sec.-butyl or the group -C(CH3)〓CH-A in which A represents methyl, ethyl or isopropyl; and R3 represents hydrogen; C1-C10-alkyl; C1-C10-alkyl substituted by at least one substituent selected from the group consisting of halogen, C1-C6-alkoxy, C2-C6-alkoxyalkoxy, C3-C9-alkoxyalkoxyalkoxy, C1-C6-alkylthio, C3-C7-cycloalkyl, C1-C3-alkyl-substituted C3-C7-cycloalkyl, hydroxy, benzyloxy, C1-C6-acyl and C1-C6-acyloxy, it being possible for each of the above-mentioned radicals representing or containing an alkoxy group to be terminally substituted at a terminal alkoxy group by hydroxy, halogen, C1-C6-acyl or by C1-C6-acyloxy; C3-C7-cycloalkyl; C3-C7-cycloalkyl substituted by at least one substituent selected from the group consisting of halogen and C1-C3-alkyl; C3-C7-cycloalkenyl; C2-C10-alkenyl; C2-C10-alkynyl; a radical selected from the group consisting of C2-C10-alkenyl and C2-C10-alkynyl, which radical is substituted by halogen, C1-C6-alkoxy or by C1-C6-acyloxy; 1-adamantylmethyl; menthyl; carveyl; phenyl; benzyl; naphthyl; a radical selected from the group consisting of phenyl, benzyl and naphthyl, which radical is substituted by at least one substituent selected from the group consisting of halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C1-C3-haloalkoxy, C1-C3-alkylthio, nitro and cyano; benzyl substituted by a phenoxy group; or a four- to six-membered heterocyclic radical that has from one to three hetero atoms selected from the group consisting of oxygen, sulfur and nitrogen and that is unsubstituted or is substituted by at least one substituent selected from the group consisting of halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C1-C3-haloalkoxy, C1-C3-alkylthio, nitro and cyano, it being possible for the said heterocyclic radical also to be bonded via a C1-C6-alkylene bridge to the oxygen atom in the 5′-position of the tetrahydrofuran ring, their preparation and their use against parasites in productive livestock and against insect pests, are described.
대표청구항
▼
A compound of formula II [Figure] (II) in which R1 is hydrogen or a OH-protecting group; R2 is methyl, ethyl, isopropyl, sec-butyl or the group -C(CH3)〓CH-A in which A is methyl, ethyl or isopropyl; and R10 and R11, independently of one another, are each C1-C6-alkyl or together represent a C2-C10-al
A compound of formula II [Figure] (II) in which R1 is hydrogen or a OH-protecting group; R2 is methyl, ethyl, isopropyl, sec-butyl or the group -C(CH3)〓CH-A in which A is methyl, ethyl or isopropyl; and R10 and R11, independently of one another, are each C1-C6-alkyl or together represent a C2-C10-alkylene bridge.
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