초록 ▼

Monodisperse, polymeric microspheres are formed by injecting uniformly shaped droplets of radiation polymerizable monomers, preferably a biocompatible monomer, having covalent binding sites such as hydroxyethylmethacrylate, into a zone, impressing a like charge on the droplet so that they mutually r

Monodisperse, polymeric microspheres are formed by injecting uniformly shaped droplets of radiation polymerizable monomers, preferably a biocompatible monomer, having covalent binding sites such as hydroxyethylmethacrylate, into a zone, impressing a like charge on the droplet so that they mutually repel each other, spheroidizing the droplets within the zone and collecting the droplets in a pool of cryogenic liquid. As the droplets enter the liquid, they freeze into solid, glassy microspheres, which vaporizes a portion of the cryogenic liquid to form a layer. The like-charged microspheres, suspended within the layer, move to the edge of the vessel holding the pool, are discharged, fall and are collected. The collected microspheres are irradiated while frozen in the cryogenic liquid to form latent free radicals. The frozen microspheres are then slowly thawed to activate the free radicals which polymerize the monomer to form evenly-sized, evenly-shaped, monodisperse polymeric microspheres.

대표청구항 ▼

A method of forming uniform, polymeric microspheres comprising the steps of: injecting a plurality of individual, uniformly sized liquid droplets comprising radiation polymerizable monomer into a zone defined by the walls of a container in a manner in which the droplets do not contact each other or

A method of forming uniform, polymeric microspheres comprising the steps of: injecting a plurality of individual, uniformly sized liquid droplets comprising radiation polymerizable monomer into a zone defined by the walls of a container in a manner in which the droplets do not contact each other or the walls of the container; spheroidizing the droplets while in the zone to form uniformly-shaped liquid microspheres; freezing the microsphere droplets to convert the droplets into frozen uniformly shaped and sized microspheres; radiating the frozen microspheres to form latent free radicals; and slowly thawng the frozen microspheres to activate the free radicals and polymerize monomer to form the polymer.