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특허 상세정보

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Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) B28B-009/10    B29C-035/00   
미국특허분류(USC) 264/13 ; 264/5 ; 264/10 ; 522/5
출원번호 US-0167877 (1988-03-14)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 147  인용 특허 : 15
초록
▼

Monodisperse, polymeric microspheres are formed by injecting uniformly shaped droplets of radiation polymerizable monomers, preferably a biocompatible monomer, having covalent binding sites such as hydroxyethylmethacrylate, into a zone, impressing a like charge on the droplet so that they mutually repel each other, spheroidizing the droplets within the zone and collecting the droplets in a pool of cryogenic liquid. As the droplets enter the liquid, they freeze into solid, glassy microspheres, which vaporizes a portion of the cryogenic liquid to form a la...

대표
청구항
▼

A method of forming uniform, polymeric microspheres comprising the steps of: injecting a plurality of individual, uniformly sized liquid droplets comprising radiation polymerizable monomer into a zone defined by the walls of a container in a manner in which the droplets do not contact each other or the walls of the container; spheroidizing the droplets while in the zone to form uniformly-shaped liquid microspheres; freezing the microsphere droplets to convert the droplets into frozen uniformly shaped and sized microspheres; radiating the frozen microsphe...

이 특허에 인용된 특허 (15)

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  8. Rembaum Alan (Altadena CA) Gupta Amitava (Los Angeles CA) Volksen Willi (Pasadena CA). Polyvinyl pyridine microspheres. USP1979104170685.
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  15. Rembaum Alan (Pasadena CA) Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chang Manchium (Los Angeles CA). Production of monodisperse, polymeric microspheres. USP1990054929400.

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