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특허 상세정보

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Controlled release combination of carbidopa/levodopa

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61K-009/22    A61K-009/26    A61K-031/78   
미국특허분류(USC) 424/469 ; 424/470 ; 424/486 ; 424/487
출원번호 US-0444222 (1989-12-01)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 18  인용 특허 : 42
초록

A matrix or monolithic drug delivery system for the controlled release of carbidopa and levodopa consists of the two drugs uniformly dispersed in a polymer vehicle at a concentration that is greater than the solubility of either drug in the polymer. Treatment of parkinsonism with the controlled release formulation provides several advantages over treatment with the standard carbidopa/levodopa combination presently employed.

대표
청구항

A controlled release solid oral dosage formulation consisting essentially of a uniform dispersion of 5-300 mg of carbidopa, 20-1200 mg of levodopa in a polymer vehicle of 2 to 120 mg of polymethyl methacrylate, whereby following administration the carbidopa and levodopa are released slowly and simultaneously from the formulation.

이 특허에 인용된 특허 (42)

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  2. Bagli Jehan F. (Kirkland CAX) Bgri Tibor (Montreal CAX) Voith Katherine (Dorval CAX). 2-(4-Hydroxyalkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives. USP1984094469695.
  3. Bagli Jehan F. (Kirkland CAX) Bgri Tibor (Montreal CAX) Voith Katherine (Dorval CAX). 2-(4-Substituted alkyl-1-piperazinyl)-2,4,6-cycloheptatrien-1-one derivatives. USP1984094469693.
  4. Fix Joseph A. (Lawrence KS) Pogany Stefano A. (Lawrence KS). a
  5. Lee Ping I. (Berwyn PA). Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentrati. USP1986114624848.
  6. Lee Ping I. (Berwyn PA). Active agent containing hydrogel devices wherein the active agent concentration profile contains a sigmoidal concentrati. USP1988064749576.
  7. Narabayashi Hirotaro (5-12-8 Nakameguro ; Meguro-ku ; Tokyo-to JPX) Kondo Tomoyoshi (2-12-3 Sugamo ; Toshima-ku ; Tokyo-to JPX) Hayashi Akira (9-5 ; Tsukumodai 3-chome Suita-shi ; Osaka-fu JPX) Suzuk. Antiparkinsonian agent. USP1985024497826.
  8. Palfreyman Michael G. (Fegersheim FRX) McDonald Ian A. (Truchtersheim FRX). Compounds and methods for treating depression. USP1983124421767.
  9. Sabel Bernhard A. (Munich MA DEX) Freese Andrew (Jamaica Plain MA) Saltzman William M. (Somerville MA). Controlled drug delivery system for treatment of neural disorders. USP1989114883666.
  10. Dempski Robert E. (Dresher PA) Scholtz Edward C. (King of Prussia PA) Nibbelink Donald W. (Lansdale PA) Reines Scott A. (New Hope PA). Controlled release combination of carbidopa/levodopa. USP1990024900755.
  11. Dempski Robert E. (Dresher PA) Scholtz Edward C. (King of Prussia PA) Nibbelink Donald W. (Lansdale PA) Reines Scott A. (New Hope PA). Controlled release combination of carbidopa/levodopa. USP1989054832957.
  12. Mueller, Karl F.; Heiber, Sonia J.. Crosslinked, porous polymers for controlled drug delivery. USP1985104548990.
  13. Heller Jorge (Palo Alto CA) Baker Richard W. (Bend OR). Device for delivery of useful agent. USP1977034014987.
  14. Theeuwes Felix (1643 Fallen Leaf La. Los Altos CA 94022) Wong Patrick S.-L. (1371 Xavier Ave. Hayward CA 94545) Cortese Richard (20802 Laurel Rd. Los Gatos CA 95030) Eckenhoff James B. (1080 Autumn L. Dispenser comprising displaceable matrix with solid state properties. USP1990074940465.
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  17. Nishimura Kenji (Tokyo JA) Arai Mikio (Tokyo JA) Sasahara Kunihiro (Tokyo JA) Nitanai Takashi (Tokyo JA). Effervescent enteric coated L-dopa formulation and method of using the same. USP1976063961041.
  18. Sheth Prabhakar R. (Pearl River NY) Tossounian Jacques L. (Pine Brook NJ). Hydrodynamically balanced controlled release compositions containing L-dopa and a decarboxylase inhibitor. USP1984014424235.
  19. Amidon Gordon L. (Ann Arbor MI) Higuchi Takeru (Lawrence KS) Dressman Jennifer B. (Ann Arbor MI). Lipid osmotic pump. USP1987084685918.
  20. Mueller Karl F. (New York NY) Heiber Sonia J. (Bedford Hills NY). Membrane modified hydrogels. USP1983124423099.
  21. Pack Howard M. (12 Herkimer Rd. Scarsdale NY 10583). Method and composition for reducing weight. USP1984054446138.
  22. Fahn Stanley (155 Edgars La. Hastings-on-Hudson NY 10706). Method and compositions of treating Parkinsonisms with levodopa and 3′,4′-dihydroxy-2-methylisopropiophenone. USP1980024190672.
  23. Palfreyman Michael G. (Fegersheim FRX) McDonald Ian A. (Truchtersheim FRX). Method for treating depression. USP1983114413012.
  24. Scriabine Alexander (Ambler PA). Method of treating hypertension. USP1983064389415.
  25. Tice Thomas R. (Helena AL) Lewis Danny H. (Gardendale AL). Microencapsulation process. USP1983064389330.
  26. Zentner Gaylen M. (Lawrence KS) Himmelstein Kenneth J. (Irvine CA) Rork Gerald S. (Lawrence KS). Multiparticulate controlled porosity osmotic. USP1989074851228.
  27. Cortese Richard (San Jose CA) Theeuwes Felix (Los Altos CA). Osmotic device with hydrogel driving member. USP1982054327725.
  28. Wong Patrick S.-L. (Hayward CA) Barclay Brian L. (Sunnyvale CA) Oeters Joseph C. (Mountain View CA) Theeuwes Felix (Los Altos CA). Osmotic system comprising plurality of members for dispensing drug. USP1988114783337.
  29. Mori Tadashi (Kyoto JPX) Nakajima Teruo (Osaka JPX). Pharmaceutical composition and method for treatment of psychomotor excitement. USP1985074529603.
  30. Chiesi Paolo (Parma ITX). Pharmaceutical compositions containing levodopa methyl ester, preparation and therapeutic applications thereof. USP1989054826875.
  31. Newton John M. (London GB2) Devereux Jane E. (London GB2). Pharmaceutical formulations. USP1990074938967.
  32. Bechgaard Helle (Hellerup DKX) Houmoller Peter (Taastrup DKX). Pharmaceutical multiple-units formulation. USP1986084606909.
  33. Seyfried Christoph (Darmstadt DT) Nowak Herbert (Darmstadt DT). Pharmaceutical preparation and method for treatment of parkinsonism. USP1977054021555.
  34. Appelgren Curt H. (Kungsbacka SEX) Eskilsson Eva C. (Mlnlycke SEX) Uvdal Jonas P. (Gothenburg SEX). Process for preparing rapidly disintegrating granulates. USP1989064840799.
  35. Eckenhoff James B. (Los Altos CA) Cortese Richard (Los Gatos CA) Landrau Felix A. (Milpitas CA). Self controlled release device for administering beneficial agent to recipient. USP1987094692336.
  36. Schor Joseph M. (Locust Valley NY) Nigalaye Ashok (Jackson Heights NY) Gaylord Norman G. (New Providence NJ). Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose. USP1983064389393.
  37. Leong Helen (Atherton CA) Katz Martin (Menlo Park CA) Delk Ann (Kensington CA) Nacht Sergio (Los Altos CA) Berliner David (Atherton CA). Synthetic melanin aggregates. USP1989084855144.
  38. Leong Helen (Atherton CA) Katz Martin (Menlo Park CA) Delk Anne (Kensington CA) Berliner David (Atherton CA) Nacht Sergio (Los Altos CA). Synthetic melanin aggregates. USP1989024806360.
  39. Hammond Michael Douglas (Chesham EN) Schneider Cyril (Whitton EN). Treatment of ethanol withdrawal symptoms with levodopa. USP1976113995058.
  40. Holland Donald R. (Indianapolis IN). Treatment of hypertension with fluoxetine and l-5-hydroxytryptophane. USP1982054329356.
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  42. Mueller Karl F. (New York NY) Good William R. (Yorktown Heights NY). Water-insoluble hydrophilic copolymers used as carriers for medicaments and pesticides. USP1979124177056.

이 특허를 인용한 특허 피인용횟수: 18

  1. Xiang, Jia-Ning; Zhou, Cindy X.; Yao, Fenmei; Nguyen, Mark Q.. Catechol protected levodopa diester prodrugs, compositions, and methods of use. USP2010117829592.
  2. Xiang, Jia-Ning; Zhou, Cindy X.; Yao, Fenmei; Nguyen, Mark Q.. Catechol protected levodopa diester prodrugs, compositions, and methods of use. USP2012128324273.
  3. Xiang, Jia-Ning; Zhou, Cindy X.; Yao, Fenmei; Nguyen, Mark Q.. Levodopa dimethyl-substituted diester prodrugs compositions, and methods of use. USP2010057709527.
  4. Xiang, Jia-Ning; Zhou, Cindy X.; Yao, Fenmei; Nguyen, Mark Q.. Levodopa dimethyl-substituted diester prodrugs, compositions, and methods of use. USP2012128324272.
  5. Karaborni, Sami; Leung, Manshiu; Mao, Chen; Thalladi, Venkat. Levodopa prodrug mesylate hydrate. USP2013038399513.
  6. Karaborni, Sami; Leung, Manshiu; Mao, Chen; Thalladi, Venkat R.. Levodopa prodrug mesylate hydrate. USP2014058722733.
  7. Xiang, Jia Ning; Dai, Xuedong; Zhou, Cindy X.; Li, Jianhua; Nguyen, Mark Q.. Levodopa prodrug mesylate, compositions thereof, and uses thereof. USP2009077563821.
  8. Xiang, Jia-Ning; Dai, Xuedong; Zhou, Cindy X.; Li, Jianhua; Nguyen, Mark Q.. Levodopa prodrug mesylate, compositions thereof, and uses thereof. USP2012068193242.
  9. Xiang, Jia-Ning; Dai, Xuedong; Zhou, Cindy X.; Li, Jianhua; Nguyen, Mark Q.. Levodopa prodrug mesylate, compositions thereof, and uses thereof. USP2011067968597.
  10. Xiang, Jia-Ning; Dai, Xuedong; Zhou, Cindy X.; Li, Jianhua; Nguyen, Mark Q.. Levodopa prodrug mesylate, compositions thereof, and uses thereof. USP2011027893105.
  11. Xiang, Jia-Ning; Gallop, Mark A.; Zhou, Cindy X.; Nguyen, Mark; Dai, Xuedong; Li, Jianhua; Cundy, Kenneth C.; Jumbe, Nelson L.. Levodopa prodrugs, and compositions and uses thereof. USP2010037671089.
  12. Xiang, Jia-Ning; Gallop, Mark A.; Zhou, Cindy X.; Nguyen, Mark; Dai, Xuedong; Li, Jianhua; Cundy, Kenneth C.; Jumbe, Nelson L.. Levodopa prodrugs, and compositions and uses thereof. USP2012048163958.
  13. Xiang,Jia Ning; Gallop,Mark A.; Zhou,Cindy X.; Nguyen,Mark; Dai,Xuedong; Li,Jianhua; Cundy,Kenneth C.. Levodopa prodrugs, and compositions and uses thereof. USP2008017323585.
  14. Raillard, Stephen P.; Mann, Adam; Manthati, Suresh K.; Scheuerman, Randall A.; Estrada, Tono; Nguyen, Mark Q.; Zhou, Cindy X. Methods of synthesizing a levodopa ester prodrug. USP2016039290445.
  15. Wenzel Udo (Halle DEX) Weber Gunther (Zwickau DEX) Metzner Jurgen (Halle DEX) Darr Alfred (Leipzig DEX) Freitag Sabine (Zwickau DEX) Flother Frank-Ulrich (Schaffhausen-Herblingen CHX) Albert Frank-Mi. Orally administrable drugs for the treatment of central dopamine deficiency conditions. USP1997045624960.
  16. Mao, Chen; Pargaonkar, Nikhil; Maurer, Laura E.; Ma, Sarina Grace Harris. Pharmaceutical compositions and oral dosage forms of a levodopa prodrug and methods of use. USP2013058435562.
  17. Sabel Bernhard A. (Egmating DEX) Freese Andrew (Jamaica Plain MA) Saltzman William M. (Baltimore MD) During Matthew J. (Westport CT). Polymeric device for controlled drug delivery to the CNS. USP1997025601835.
  18. Fleshner-Barak, Moshe; Lerner, E. Itzhak; Rosenberger, Vered; Dahan, Mazal; Makov, Yisrael. Rapidly expanding composition for gastric retention and controlled release of therapeutic agents, and dosage forms including the composition. USP2010037674480.

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