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An adhesive for percutaneous administration having a drug-containing layer composed of a base component mainly comprising a heat-sensitive and water-sensitive amphiphilic polymer and a drug incorporated in the base component. The amphiphilic compound has a characteristic hydrophobicity-hydrophilicit

An adhesive for percutaneous administration having a drug-containing layer composed of a base component mainly comprising a heat-sensitive and water-sensitive amphiphilic polymer and a drug incorporated in the base component. The amphiphilic compound has a characteristic hydrophobicity-hydrophilicity tapered structure, and a variety of liquid or solid or lipophilic (hydrophobic) or hydrophilic drugs of a broad range can stably be dissolved or dispersed therein. The drug in the drug-containing layer remains stable without being released or diffused while the adhesives are stored, and upon application to the skin, the drug is gradually released and diffused into the skin with high availability in a specifically controlled pattern. The present adhesive is especially advantageous for endermic presentation of a slight amount of a substance of high physiological activity which is unstable and is easily decomposed by heat or water.

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An adhesive for percutaneous administration, comprising a layer containing a heat-sensitive and water-sensitive amphiphilic polymer and a biologically active agent, wherein said heat-sensitive and water-sensitive amphiphilic polymer is a multi-block copolymer comprising a reaction product of an alky

An adhesive for percutaneous administration, comprising a layer containing a heat-sensitive and water-sensitive amphiphilic polymer and a biologically active agent, wherein said heat-sensitive and water-sensitive amphiphilic polymer is a multi-block copolymer comprising a reaction product of an alkyleneoxide-polyether-polyol, an aliphatic polyester-polyol or an aliphatic polyether-polyol and a diisocyanate, wherein said multi-block copolymer is represented by the following general formula (A): [Figure] (A) wherein (S) is selected from the group consisting of: (a) a polyalkylene segment represented by the following general formula (I): －R1－O－1-O)l(I) wherein R1 to Rx each represents an alkylene group having from 7 to 2 carbons, the number of carbon atoms in each group of the series R1 to Rx being less than the number of carbon atoms in the previous alkylene groups of the series from R1 to Rx, provided that the number of carbon atoms in any two immediately adjacent members of the series R1 to Rx may be equal, and any alkyleneoxide group containing said alkylene group of the series from R1 to Rx may be omitted; (b) an aliphatic polyester segment which is the reaction product of a dibasic acid and a dihydric alcohol represented by the following general formula (II): [Figure] (II) wherein R1 and R1′, which may the same or different, each represents an alkylene group, R1 represents an alkylene group of dihydric alcohol, the total number of carbon atoms in R1 and R1′is greater than the number of carbon atoms in R2, R2 to Rx each represents an alkylene group having from 4 to 2 carbon atoms, the number of carbon atoms in each group of the series R2 to Rx being less than the number of carbon atoms in the previous alkylene groups of the series from R2 to Rx, provided that the number of carbon atoms in any two immediately adjacent members of the series R2 to Rx may be equal, and any alkyleneoxide group containing said alkylene group of the series from R2 to Rx may be omitted; and (c) a polyester segment which is the reaction product of a ring-cleaved polymer of a cyclic ester and a dihydric alcohol represented by the following general formula (III): [Figure] (III) wherein R1′and R1″, which may be the same or different, each represents a reaction of a ring-cleaved polymer of a cyclic ester containing 5 carbon atoms, R1 represents an alkylene group of said dihydric alcohol, R2 to Rx each represents an alkylene group having from 4 to 2 carbon atoms, the number of carbon atoms in each group of the series R2 to Rx being less than the number of carbon atoms in the previous alkylene groups of the series from R2 to Rx, provided that the number of carbon atoms in any two immediately adjacent members of the series R2 to Rx may be equal, and any alkyleneoxide group containing said alkylene group of the series from R2 to Rx may be omitted; and in general formula (A), －OX represents a group selected from the group consisting of RO－, RCOO－, [Figure] , R－NHCOO－, and ROOCHN－ －NHCOO－, wherein R represents an alkyl group having 1 to 18 carbon atoms or a vinyl group and represents an isocyanate skeleton group; －OX′represents a group selected from the group consisting of －OH, －OCl, －OBr and －OF; l, l′, m, n and p, which may be the same or different, each is a positive integer; and (A), (B) and (C), which may be the same or different, each represents an isocyanate skeleton group.