초록 ▼

The lubricious hydrophilic coatings of the invention include a hydrophilic polyolefin such as polyvinyl-pyrrolidone and a water-insoluble stabilizing polymer such as a cellulose ester. The coatings may also include an adherent polymer and a plasticizing agent. The coatings are significantly more lub

The lubricious hydrophilic coatings of the invention include a hydrophilic polyolefin such as polyvinyl-pyrrolidone and a water-insoluble stabilizing polymer such as a cellulose ester. The coatings may also include an adherent polymer and a plasticizing agent. The coatings are significantly more lubricious when wet than when dry, are adherent to a variety of substrates, and are resistant to removal by wet abrasion. The coating method of the invention involves preparing a solution of the stabilizing polymer and a solution of the hydrophilic polyolefin, and coating the substrate first in one then the other. Alternatively, both the insolubilizing and hydrophilic polymers may be dissolved in a single solvent system and applied to the substrate in a single step. The solutions of the invention are stable, non-reactive, and non-hazardous. The coatings of the invention may be applied to biomedical devices and implants such as catheters, condoms, and nasogastric and endotracheal tubes.

대표청구항 ▼

A lubricious composite, comprising an outer layer having an exposed outer surface, said outer layer comprising a hydrophilic polymer selected from the group consisting of polyvinylpyrollidone, polyvinylpyrollidone-polyvinyl acetate copolymer, a mixture of the above, and the like, an inner layer comp

A lubricious composite, comprising an outer layer having an exposed outer surface, said outer layer comprising a hydrophilic polymer selected from the group consisting of polyvinylpyrollidone, polyvinylpyrollidone-polyvinyl acetate copolymer, a mixture of the above, and the like, an inner layer comprising a water-insoluble stabilizing polymer selected from the group consisting of a cellulose ester, a copolymer of polymethyl vinyl ether and maleic anhydride, an ester of the copolymer, and nylon, said composite being substantially more slippery when wet than when dry, resistant to removal by wet abrasion, and essentially insoluble in aqueous solution, the ratio of said hydrophilic polymer to said stabilizing polymer altering the degree of wet lubricity, resistance to removal, and insolubility of said composite.