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Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and st 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/00
출원번호 US-0478741 (1990-02-12)
우선권정보 JP-0211157 (1986-09-08); JP-0013726 (1987-01-23)
발명자 / 주소
  • Ohtsuka Eiko (Sappro JPX) Inoue Hideo (Sappro JPX) Morisawa Hirokazu (Kawasaki JPX) Shibahara Susumu (Kawasaki JPX) Mukai Sachiko (Kawasaki JPX) Nishihara Tohru (Kurashiki JPX)
출원인 / 주소
  • Ajinomoto Co., Inc. (Tokyo JPX 03)
인용정보 피인용 횟수 : 242  인용 특허 : 5

초록 ▼

There is disclosed a compound having a double chain which is composed of an RNA (+chain) and a complementary DNA (-chain), wherein a portion of the DNA (-chain) has been replaced by an RNA or a derivative thereof, and wherein, when the compound is subjected to the action of an enzyme having a ribonu

대표청구항 ▼

A compound having a double chain and which is composed of an RNA (+chain) and a complementary DNA (-chain), wherein at least one portion of said DNA (-chain) has been replaced by a 2′-O-substituted RNA, wherein said 2′-O-substituted RNA has at least one substituted 2′-hydroxyl group on the ribose mo

이 특허에 인용된 특허 (5)

  1. Kempe Tomas (Minnetonka MN) Purchio Anthony F. (Edina MN) Collett Marc S. (Minnetonka MN) DeLorbe William J. (Minnetonka MN), Molecular cloning of RNA using RNA ligase and synthetic oligonucleotides.
    상세보기
  2. Caruthers Marvin H. (Boulder CO) Beaucage Serge L. (Boulder CO), Phosphoramidite compounds and processes.
    상세보기
  3. Kster Hubert (Hamburg DEX) Sinha Nanda D. (Bundu Dt. Ranchi INX), Process for the preparation of oligonucleotides.
    상세보기
  4. Paddock Gary V. (Mount Pleasant SC), Recombinant cDNA construction method and hybrid nucleotides useful in cloning.
    상세보기
  5. Itakura Keiichi (Arcadia CA), Solid-phase synthesis of polynucleotides.
    상세보기

이 특허를 인용한 특허 (242)

  1. Buhr Chris A. ; Matteucci Mark, 2' Modified Oligonucleotides.
    상세보기
  2. Chris A. Buhr ; Mark Matteucci, 2' Modified oligonucleotides.
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  3. Cook Phillip Dan ; Manoharan Muthiah ; Kawasaki Andrew Mamoru, 2'-O-aminooxy-modified oligonucleotides.
    상세보기
  4. Cook Phillip Dan ; Guinosso Charles John, 2'-O-modified nucleosides and phosphoramidites.
    상세보기
  5. Cook Phillip Dan ; Kawasaki Andrew Mamoru, 2'-O-modified oligonucleotides.
    상세보기
  6. Cook Phillip Dan ; Kawasaki Andrew Mamoru, 2'-modified oligonucleotides.
    상세보기
  7. Cook Phillip Dan ; Kawasaki Andrew Mamoru, 2'-modified oligonucleotides.
    상세보기
  8. Cook, Phillip Dan; Kawasaki, Andrew Mamoru, 2'modified oligonucleotides.
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  9. Buhr, Chris A.; Matteucci, Mark, 2′ Modified oligonucleotides.
    상세보기
  10. Prakash, Thazha P.; Baker, Brenda F.; Eldrup, Anne B.; Manoharan, Muthiah; Bhat, Balkrishen; Griffey, Richard; Swayze, Eric E.; Crooke, Stanley T., 2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations.
    상세보기
  11. Seth, Punit P.; Swayze, Eric E.; Bhat, Balkrishen, 5'-modified bicyclic nucleic acid analogs.
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  12. Swayze, Eric E.; Prakash, Thazha P., 5′ and 2′ BIS-substituted nucleosides and oligomeric compounds prepared therefrom.
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  13. Seth, Punit P.; Swayze, Eric E.; Bhat, Balkrishen, 5′-modified bicyclic nucleic acid analogs.
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  14. Seth, Punit P.; Swayze, Eric E.; Bhat, Balkrishen, 5′-modified bicyclic nucleic acid analogs.
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  15. Seth, Punit P.; Swayze, Eric E.; Bhat, Balkrishen, 5′-modified bicyclic nucleic acid analogs.
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  16. Seth, Punit P.; Swayze, Eric E., 6-disubstituted or unsaturated bicyclic nucleic acid analogs.
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  17. Seth, Punit P.; Swayze, Eric E., 6-modified bicyclic nucleic acid analogs.
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  18. Seth, Punit P.; Swayze, Eric E., 6-modified bicyclic nucleic acid analogs.
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  19. Seth,Punit P.; Swayze,Eric E., 6-modified bicyclic nucleic acid analogs.
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  20. Manoharan, Muthiah; Lonnberg, Harri; Salo, Harri; Virta, Pasi, Aminooxy functionalized oligomers.
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  57. Migawa, Michael T.; Lima, Walter F.; Swayze, Eric E.; Nichols, Joshua; Wu, Hongjiang; Prakash, Thazha P.; Wyrzykiewicz, Tadeusz Krzysztof; Bhat, Balkrishen; Crooke, Stanley T., Compositions and methods for optimizing cleavage of RNA by RNase H.
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  66. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of DGAT2.
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  67. Bhanot, Sanjay; Geary, Richard; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of GCCR.
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  68. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of GCGR.
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  69. Bhanot, Sanjay; Geary, Richard S.; McKay, Robert; Monia, Brett P.; Seth, Punit P.; Siwkowski, Andrew M.; Swayze, Eric E.; Wancewicz, Edward, Compounds and methods for modulating expression of SGLT2.
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  70. Bennett, C. Frank, Compounds and methods for modulating protein expression.
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  75. Peled, Tony; Steinhardt, Yair, Culturing of mesenchymal stem cells with FGF4 and nicotinamide.
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