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Very low temperature casting of controlled release microspheres 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/58
  • B29B-009/00
  • C08K-007/16
  • B01J-013/02
출원번호 US-0346143 (1989-05-01)
발명자 / 주소
  • Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA)
출원인 / 주소
  • Enzytech, Inc. (Cambridge MA 02)
인용정보 피인용 횟수 : 360  인용 특허 : 15

초록 ▼

A process for preparing microspheres using very cold temperatures to freeze polymer-biologically active agent mixtures into polymeric microspheres with very high retention of biological activity and material. Polymer is dissolved in a solvent together with an active agent that can be either dissolve

대표청구항 ▼

A method for preparing polymeric microspheres comprising a) freezing droplets of polymer solution by atomizing the droplets into a liquified gas, having a temperature below the freezing point of the polymer solution effective to immediately freeze the atomized polymer solution upon contact, said liq

이 특허에 인용된 특허 (15)

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  7. Tice Thomas R. (Helena AL) Lewis Danny H. (Gardendale AL), Microencapsulation process.
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  8. Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chung Sang-Kun (Diamond Bar CA) Colvin Michael S. (Malibu CA) Chang Manchium (Los Angeles CA), Monodisperse, polymeric microspheres produced by irradiation of slowly thawing frozen drops.
    상세보기
  9. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
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  10. De Luca Patrick P. (Lexington KY) Rypacek Frantisek (Leckova CZX), Preparation of biodegradable microspheres useful as carriers for macromolecules.
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  11. Morishita Masataka (Shizuoka JA) Inaba Yoshihito (Shizuoka JA) Fukushima Mitsuru (Shizuoka JA) Kobari Sadami (Shizuoka JA) Nagata Akiho (Shizuoka JA) Abe Jinnosuke (Shizuoka JA), Preparation of microcapsules.
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  12. Morishita Masataka (Shizuoka JA) Inaba Yoshihito (Shizuoka JA) Fukushima Mitsuru (Shizuoka JA) Hattori Yoshinori (Shizuoka JA) Kobari Sadami (Shizuoka JA) Matsuda Tetsuo (Shizuoka JA), Process for encapsulation of medicaments.
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  15. Rembaum Alan (Pasadena CA) Rhim Won-Kyu (Pasadena CA) Hyson Michael T. (Glendale CA) Chang Manchium (Los Angeles CA), Production of monodisperse, polymeric microspheres.
    상세보기

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