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Drug delivery apparatus and method preventing local and systemic toxicity

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61M-005/14
출원번호 US-0518272 (1990-05-04)
발명자 / 주소
  • Needham Thomas E. (Deerfield IL) Wright Jeremy C. (Lake Forest IL) Pearson Steve (Ingleside IL) Chilamkurti Rao (West Chicago IL) Kopp Clinton V. (Barrington IL)
출원인 / 주소
  • Baxter International Inc. (Deerfield IL 02)
인용정보 피인용 횟수 : 76  인용 특허 : 41

초록

An apparatus is provided for the safe, passive reconstruction of a drug or other beneficial agent, without requiring manual reconstitution steps. The apparatus includes a housing, preferably having a receptacle “in-line”in an administration set and forming part of an intravenous delivery system, and

대표청구항

Apparatus for the safe delivery of a beneficial agent to a patient, comprising: (a) means defining a chamber adapted for receiving a beneficial agent, said chamber having a fluid pathway therethrough, said chamber-defining means including an inlet and an outlet defining part of said fluid pathway; a

이 특허에 인용된 특허 (41)

  1. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), Apparatus for parenteral infusion of fluid containing beneficial agent.
  2. Virag Robert A. (Lake Zurich IL), Burette chamber for use with intravenous solution administration set.
  3. Pearson Stephen (Ingleside IL) Lyons Steffen A. (Grayslake IL), Closed drug delivery system.
  4. Kaufman Stephen B. (Heather Ridge IL) Hart John W. (Winnetka IL) Chamernik Richard (Waukegan IL), Container for mixing a liquid and a solid.
  5. Akers Michael J. (Greenwood IN) Hargrove William W. (Indianapolis IN) Harris Dale C. (Fairland IN) Sperry Charles R. (Westport CT), Controlled release infusion system.
  6. Geller Leo (Riehen CHX), Device for releasing active ingredient, insertable in a system of parenteral administering the ingredient.
  7. Israel Michael B. (29 Gann Rd. East Hampton NY 11937), Exponential mixing and delivery system.
  8. Wolfe Allan M. (South Laguna CA) Davenport James M. (Tustin CA) Theeuwes Felix (Los Altos CA) Yum Su I. (Sunnyvale CA), Formulation dispenser for use with a parenteral delivery system.
  9. Wolfe Allan M. (South Laguna CA) Davenport James M. (Tustin CA) Theeuwes Felix (Los Altos CA) Yum Su I. (Sunnyvale CA), In-line drug dispenser for use in intravenous therapy.
  10. Elias Allen M. (Mundelein IL), In-line transfer unit.
  11. Harris Dale C. (Fairland IN) Hargrove William W. (Indianapolis IN), Intravenous administration system for dry medicine.
  12. Riddell James G. (Belfast GB5), Intravenous drug infusion apparatus.
  13. Theeuwes Felix (Los Altos CA), Intravenous system for delivering a beneficial agent.
  14. Zaffaroni Alejandro (Atherton CA), Microporous drug delivery device.
  15. Lyons Steffen A. (Grayslake IL), Mixing apparatus.
  16. Zaffaroni Alejandro (Atherton CA), Novel drug delivery device.
  17. Zaffaroni Alejandro (Atherton CA), Novel drug delivery device.
  18. Michaels Alan S. (San Francisco CA) Guillod Mark S. (Kaneohe HI), Osmotic bursting drug delivery device.
  19. Higuchi Takeru (Lawrence KS) Leeper Harold M. (Mountain View CA), Osmotic dispenser with means for dispensing active agent responsive to osmotic gradient.
  20. Zaffaroni ; Alejandro ; Michaels ; Alan S. ; Theeuwes ; Felix, Osmotic releasing device having a plurality of release rate patterns.
  21. Theeuwes ; Felix, Osmotic system for the controlled and delivery of agent over time.
  22. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), Parenteral administration.
  23. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), Parenteral administration using drug delivery device.
  24. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), Parenteral administration using osmotically motivated delivery system.
  25. Theeuwes Felix (Los Altos CA), Parenteral agent dispensing equipment.
  26. Theeuwes Felix (Los Altos CA), Parenteral agent dispensing equipment.
  27. Theeuwes, Felix, Parenteral agent dispensing equipment.
  28. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), Parenteral controlled delivery.
  29. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), Parenteral controlled therapy.
  30. Urquhart, John; Theeuwes, Felix, Parenteral controlled therapy.
  31. Urquhart, John; Theeuwes, Felix, Parenteral controlled therapy.
  32. Theeuwes Felix (Los Altos CA), Parenteral delivery system utilizing a hollow fiber cellular unit.
  33. Theeuwes Felix (Los Altos CA) Urquhart John (Palo Alto CA), Parenteral delivery system with in-line container.
  34. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), Parenteral therapy using solid drug.
  35. Pearson Stephen (Ingleside IL), Sterile coupling.
  36. Pearson Stephen (Ingleside IL), Sterile coupling.
  37. Theeuwes, Felix, System for intravenous delivery of a beneficial agent.
  38. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), System for intravenous therapy.
  39. Urquhart John (Palo Alto CA) Theeuwes Felix (Los Altos CA), System for parenteral administration of agent.
  40. Lemonnier Jean (Le Vesinet FRX), Test method and apparatus for the presence of microorganisms in ampoule.
  41. Hargrove William W. (Indianapolis IN) Harris Dale C. (Fairland IN) Akers Michael J. (Greenwood IN) Sperry Charles R. (Westport CT), Vacuum vial infusion system.

이 특허를 인용한 특허 (76)

  1. Sancoff Gregory E. (Windham NH) Doyle Mark C. (San Diego CA) Field Frederic P. (Solana Beach CA), Apparatus and methods for multiple fluid infusion.
  2. Shalwitz Robert A. ; Cole Rhonda L. ; Geckle Ronita K. ; Kropczynski John J. ; Mazer Terrence B. ; Walton Joseph E., Apparatus for altering the characteristics of a fluid.
  3. Woodworth,Archie; Reed,William; Adams,David J.; Martine, Jr.,John A.; Smith,Jeffery; Steeber,Michael; Korzeniewski,Kim, Apparatus for fabricating a reconstitution assembly.
  4. Mori Kenji (2041-1 ; Naka Tamana-shi ; Kumamoto-ken JPX) Akaike Yoshiaki (Yamanashi-ken JPX), Device for dissolving and delivering a drug in a transfusion liquid.
  5. Brugger,James; Buckler,Kenneth E., Dual access spike for infusate bags.
  6. Finke, Melvin A., Fluid delivery device with filtration.
  7. Nelson, David, Fluid manifold.
  8. Nelson, David, Fluid manifold.
  9. Nelson, David, Fluid manifold.
  10. Brugger,James M.; Treu,Dennis M., Fluid processing apparatus.
  11. Shigezawa, Gordon, Intravenous fluid heating system.
  12. Sancoff Gregory E. (Rancho Santa Fe CA) Doyle Mark C. (San Diego CA), Liquid delivery device.
  13. Sancoff Gregory E. (Rancho Sante Fe CA) Doyle Mark C. (San Diego CA) Field Frederic P. (Solana Beach CA), Liquid delivery device having a vial attachment or adapter incorporated therein.
  14. Fangrow, Jr., Thomas F., Medical connector.
  15. Fangrow, Jr., Thomas F., Medical connector.
  16. Fangrow, Jr., Thomas F., Medical connector.
  17. Fangrow, Jr., Thomas F., Medical connector.
  18. Fangrow, Jr., Thomas F., Medical connector.
  19. Fangrow, Jr., Thomas F., Medical connector.
  20. Fangrow, Jr., Thomas F., Medical connector.
  21. Fangrow, Thomas F., Medical connector.
  22. Fangrow, Thomas F., Medical connector.
  23. Fangrow, Thomas F., Medical connector.
  24. Fangrow, Thomas F., Medical connector having high flow rate characteristics.
  25. Fangrow, Jr., Thomas F., Medical connector with automatic valves and volume regulator.
  26. Fangrow, Thomas F., Medical connectors and methods of use.
  27. Fangrow, Thomas F., Medical connectors and methods of use.
  28. Fangrow, Thomas F., Medical connectors and methods of use.
  29. Lopez, George A.; Fangrow, Jr., Thomas F.; Foret, Bob, Medical connectors and methods of use.
  30. Lopez, George A.; Fangrow, Jr., Thomas F.; Foret, Bob, Medical connectors and methods of use.
  31. Lopez, George A.; Fangrow, Thomas F.; Foret, Bob, Medical connectors and methods of use.
  32. Lopez, George A.; Fangrow, Thomas F.; Foret, Bob, Medical connectors and methods of use.
  33. Lopez, George A.; Fangrow, Thomas F.; Foret, Bob, Medical connectors and methods of use.
  34. Ryan Dana Wm., Medical intravenous administration line connectors having a luer activated valve.
  35. Ryan Dana Wm., Medical intravenous administration line connectors having a luer or pressure activated valve.
  36. Ryan Dana Wm., Medical intravenous administration line connectors having a luer or pressure activated valve.
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  40. Lopez, George A., Medical valve and method of use.
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  42. Lopez, George A., Medical valve and method of use.
  43. Lopez, George A., Medical valve and method of use.
  44. Lopez, George A., Medical valve and method of use.
  45. Lopez, George A., Medical valve and method of use.
  46. Lopez, George A., Medical valve and method of use.
  47. Lopez, George A., Medical valve with fluid escape space.
  48. Williams, John A.; Martine, Jr., John A., Method and apparatus for validation of sterilization.
  49. Williams, John A.; Martine, Jr., John A., Method and apparatus for validation of sterilization process.
  50. Fangrow, Jr., Thomas F., Method of making a seal having slit formed therein.
  51. Ryan Dana Wm., Multiple dose drug vial adapter for use with a vial having a pierceable septum and a needleless syringe.
  52. Fangrow, Jr., Thomas F., Needleless medical connector.
  53. Fangrow, Jr., Thomas F., Needleless medical connector.
  54. Masuda Kouichirou,JPX ; Maeda Kazumasa,JPX ; Kazama Haruki,JPX, Passive drug delivery apparatus.
  55. Nishimoto Fumiaki,JPX ; Maeda Kazumasa,JPX ; Kazama Haruki,JPX ; Fowles Thomas A., Passive drug delivery apparatus.
  56. Masuda Kouichirou,JPX ; Maeda Kazumasa,JPX ; Kazama Haruki,JPX ; Gorman Brian J., Receptacle for passive drug delivery.
  57. Fowles, Thomas A.; Weinburg, Robert J., Reconstitution assembly, locking device and method for a diluent container.
  58. Fowles Thomas A. ; Weinberg Robert J. ; Progar Thomas J., Septum for a sliding reconstitution device with seal.
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  64. Fowles Thomas A. ; Progar Thomas J. ; Weinberg Robert J. ; Fuller Craig A., Sliding reconstitution device with seal.
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  69. Fowles, Thomas A.; Progar, Thomas J.; Weinberg, Robert J.; Fuller, Craig A., Sliding reconstitution device with seal.
  70. Fowles, Thomas A.; Progar, Thomas J.; Weinberg, Robert J.; Fuller, Craig A., Sliding reconstitution device with seal.
  71. Brugger, James M.; Treu, Dennis M., Systems and methods for handling air and/or flushing fluids in a fluid circuit.
  72. Brugger, James M.; Treu, Dennis M., Systems and methods for handling air and/or flushing fluids in a fluid circuit.
  73. Fowles Thomas A. ; Weinberg Robert J., Vial connecting device for a sliding reconstitution device for a diluent container.
  74. Fowles, Thomas A.; Weinberg, Robert J., Vial connecting device for a sliding reconstitution device for a diluent container.
  75. Fowles Thomas A. ; Weinberg Robert J. ; Progar Thomas J., Vial connecting device for a sliding reconstitution device with seal.
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