초록

A dosage form is disclosed comprising a coat that surrounds a drug. The coat comprises a subcoat and an overcoat thermally annealed to provide a single unit coat around the drug.

대표청구항 ▼

A dosage form for delivering a drug to a fluid environment of use, the dosage form comprising: (a) a wall comprising an annealed subcoat and overcoat, said subcoat and overcoat annealed at about 20°C. to 75°C. for about 5 to 90 hours; and wherein; (1) the subcoat comprises a member selected from the

A dosage form for delivering a drug to a fluid environment of use, the dosage form comprising: (a) a wall comprising an annealed subcoat and overcoat, said subcoat and overcoat annealed at about 20°C. to 75°C. for about 5 to 90 hours; and wherein; (1) the subcoat comprises a member selected from the group consisting of a cellulose ether, a cellulose ester and a cellulose ester-ether emulsifiers which subcoat is permeable to the passage of fluid and maintains its physical and chemical integrity in fluid; (2) the overcoat comprising a member selected from the group consisting of hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethylcellulose, and methylcellulose, and wherein said overcoat loses its physical and chemical integrity in fluid; which wall surrounds; (b) a compartment; (c) a therapeutically effective amount of drug in the compartment; and (d) at least one passageway in the wall connecting the exterior with the interior of the device for delivering the drug over time.