초록 ▼

Bioerodible ortho ester polymers useful for preparing soft form bioerodible pharmaceutical compositions such as ointments, creams, gels and the like are provided. A novel synthetic method for preparing the polymers is provided as well. Synthesis involves a one-step reaction between a monomeric ortho

Bioerodible ortho ester polymers useful for preparing soft form bioerodible pharmaceutical compositions such as ointments, creams, gels and the like are provided. A novel synthetic method for preparing the polymers is provided as well. Synthesis involves a one-step reaction between a monomeric ortho ester and a triol. The pharmaceutical compositions of the invention are useful for the controlled release of therapeutic agents, and may be administered for a variety of purposes, such as for the treatment of deep wounds, including burns, and for the treatment of periodontal disease.

대표청구항 ▼

A method for preparing a bioerodible polymer comprising: reacting a monomeric ortho ester having the general formula [Figure] wherein R is hydrogen or alkyl of 1 to 10 carbon atoms and R′is lower alkyl with a triol having the general formula [Figure] wherein A is selected from alkylenes and cycloalk

A method for preparing a bioerodible polymer comprising: reacting a monomeric ortho ester having the general formula [Figure] wherein R is hydrogen or alkyl of 1 to 10 carbon atoms and R′is lower alkyl with a triol having the general formula [Figure] wherein A is selected from alkylenes and cycloalkylenes of at least 5 carbon atoms, and oxyalkylenes and cyclooxyalkylenes of at least 5 carbons, to form without isolation of any intermediate species a nonrigid, bioerodible ortho ester polymer comprising mer units of the structure [Figure]