초록 ▼

An implantable apparatus for continuous or periodic introduction of a drug to a desired release point in the body comprises an implantable power source and an elongated flexible plastic tubular catheter having a lumen filled with the drug to be delivered and containing therein a first device electro

An implantable apparatus for continuous or periodic introduction of a drug to a desired release point in the body comprises an implantable power source and an elongated flexible plastic tubular catheter having a lumen filled with the drug to be delivered and containing therein a first device electrode. The distal end of the catheter is closed and located near the distal end is a port which extends through the wall of the catheter to communicate with the lumen. Just proximal of the port is a surface electrode mounted on the exterior wall of the catheter body. Extending through the catheter and joined to the drive electrode and the surface electrode are conductors which couple those electrodes to the implanted power source. Energization of the electrodes with a predetermined direct current potential causes a flow of the ionized drug molecules out through the port and into the area surrounding the surface electrode.

대표청구항 ▼

1. An implantable drug delivery apparatus for long-term implantation within the body of an animal comprising: p1 (a) an implantable source of direct current potential; (b) an elongated, flexible plastic tubular catheter body having a proximal end, a distal end and at least one lumen extending fro

1. An implantable drug delivery apparatus for long-term implantation within the body of an animal comprising: p1 (a) an implantable source of direct current potential; (b) an elongated, flexible plastic tubular catheter body having a proximal end, a distal end and at least one lumen extending from said proximal end to said distal end, and lumens at said distal end being closed, except for a port extending through said catheter body near said distal end; (c) first and second electrode means adapted to be connected to said source of direct current potential, said first electrode being contained within said lumen and said second electrode being a ring disposed on the exterior surface of said catheter body; and (d) A liquid solution containing a drug in solution substantially filling said sumen and engulfing said first electrode, the connection of said first and second electrodes to said source driving said drug through said port. 2. The apparatus as in claim 1 wherein said port comprises an elongated slit. 3. The apparatus as in claim 1 wherein said ring is located proximally of said port. 4. The apparatus as in claim 1 wherein said port is of a size to prevent blood or tissue intrusion into said lumen and yet permit the outflow of said solution. 5. The apparatus as in claim 4 wherein said port is an elongated narrow slit. 6. The apparatus as in claim 1 and further including a membrane having a predetermined molecular weight cut-off mounted in covering relation to said port. 7. The apparatus as in claim 6 wherein said molecular weight cut-off is such that blood and tissue is incapable of penetrating through said membrane into said port. 8. The apparatus as in claim 7 wherein said membrane is a barrier to the flow of said solution but penetrable by said drug when driven by first and second electrodes. 9. The apparatus as in claim 1 and further including said drug in crystalline form to maintain a saturated condition in said solution upon delivery of said drug through said port. 10. The apparatus as in claim 1 wherein said solution is a gel material. 11. The apparatus as in claim 10 wherein said first electrode is in contact with said gel material.