초록 ▼

The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans

The present invention relates to formulations containing unsaturated fatty acids for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems and to the use of such formulations for the preparation of medicaments which are suitable for curing prostaglandin deficiencies in humans or animal, for example healing or preventing diseases of the gastro-intestinal tract.

대표청구항 ▼

A formulation for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems, which comprises: at least one unsaturated fatty acid, defined by three to five isolated double bonds at 18 to 22 carbon atoms which are arranged in a straight chain and can be methylated or ethylated at

A formulation for the synthesis of prostaglandins and hydroxy-fatty acids in biological systems, which comprises: at least one unsaturated fatty acid, defined by three to five isolated double bonds at 18 to 22 carbon atoms which are arranged in a straight chain and can be methylated or ethylated at one or two carbon atoms in positions 2, 3, 4, 16, 17, 18, 19 or 20, as the free carboxylic acid with terminal －CO2H, or as the carboxamide or as －CO2X, X being a protective group which can be eliminated under acidic conditions or a 1- or 2-lysophospholipid or a metal or amine cation or the cationic form of an ion exchanger, and a stimulator capable of exhibiting a simultaneous stabilizing action selected from a cysteine, a homocysteine or a lipoic acid, the acyclic alkyl radical of which can be shortened up by to four methylene groups, with a stabilizer selected from phospholipids, sugar lipids, cyclodextrins, proteins, cytochromes of the C series or vitamins of the E series, in the solid or liquid form, wherein the weight ratio of the unsaturated fatty acid to the stimulator is between 50 and 0.1, and the weight ratio of the free unsaturated fatty acid to the stabilizer is between about 100 and 0.5.