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Reduction of oxyradical damage in biomedical applications 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-037/00
  • A61K-031/40
출원번호 US-0554197 (1990-07-17)
발명자 / 주소
  • Wu Tai-Wing (Toronto CAX)
출원인 / 주소
  • Nagase Co., Ltd. (Osaka JPX 03)
인용정보 피인용 횟수 : 25  인용 특허 : 0

초록

The biliproteins delta-bilirubin and delta-bilipeptide are useful as a cytoprotective antioxidants. Delta-bilipeptide as the term is used herein is a truncated form of delta-bilirubin in which an albumin analogue of 10-200 amino acid residues replaces the albumin portion of delta-bilirubin. Patient-

대표청구항

A composition useful as an antioxidant and cytoprotective agent in treating blood in a mammal in vivo to scavenge oxidative free radicals therefrom, said composition comprising an effective amount of a bilirubin attached covalently to a peptide chain of at least 6 amino acid residues and including t

이 특허를 인용한 특허 (25)

  1. Rotstein Ori D.,CAX ITX M4S 1A6 ; Nathens Avery B.,CAX ITX M2N 5W8, Anti-inflammatory and anti-pyretic method.
  2. Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  3. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  4. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  5. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  6. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  7. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  8. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis; Fraser, Richard; Harris, Stanley; Schein, Douglas, Apparatus and method for maintaining and/or restoring viability of organs.
  9. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Schein, Douglas; Harris, Stanley; Steibel, Dennis; Fraser, Richard; Isaacs, Dickon, Apparatus and method for maintaining and/or restoring viability of organs.
  10. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Schein, Douglas; Isaacs, Dickon, Apparatus and method for maintaining and/or restoring viability of organs.
  11. Donald R. Owen, Brain resuscitation apparatus and method.
  12. McCarty, Mark Fredrick; Hendler, Sheldon Saul; Rorvik, David Michael; Inoguchi, Toyoshi, Compositions for inhibiting NADPH oxidase activity.
  13. Wright, David Walter; Garland, Jeffrey C., Device for separating gas from a liquid path.
  14. Vanasse, Tom; Gupta, Gautam; Meridew, Jason, Metallic structures having porous regions from imaged bone at pre-defined anatomic locations.
  15. Vanasse, Tom; Gupta, Gautam; Meridew, Jason, Metallic structures having porous regions from imaged bone at pre-defined anatomic locations.
  16. Wright, David Walter; Schein, Douglas; Brassil, John, Method and apparatus for controlling air pressure in an organ or tissue container.
  17. Wright, David Walter; Schein, Douglas; Brassil, John, Method and apparatus for controlling air pressure in an organ or tissue container.
  18. Schein, Douglas; Travis, Lee William, Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container.
  19. Garland, Jeffrey C.; Schein, Douglas; Wright, David Walter, Method and apparatus for transferring heat to or from an organ or tissue container.
  20. Garland, Jeffrey C; Schein, Douglas; Wright, David Walters, Method and apparatus for transferring heat to or from an organ or tissue container.
  21. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Method for controlling perfusion of an organ.
  22. Brassil, John; Schein, Douglas; Curtis, Christopher, Method of determining that an organ is not suitable for transplantation and using it for testing substances.
  23. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J; Fraser, Richard; Harris, Stanley; Schein, Douglas; Curtis, Christopher G., Method of determining transport and/or storage parameters for maintaining viability of an organ.
  24. Owen, Donald R.; Kravitz, David C., Method of transporting and storing a kidney.
  25. Zern Mark (Newtown Square PA) Huang Leaf (Wexford PA) Yoa Tony (Knoxville TN), Treatment of disease states induced by oxidative stress.
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