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Controlled release systems containing heparin and growth factors 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-013/00
  • A61F-002/00
  • A61K-009/14
출원번호 US-0206520 (1988-06-14)
발명자 / 주소
  • Edelman Elazer R. (Brookline MA) Langer Robert S. (Somerville MA) Klagsburn Michael (Newton MA) Mathiowitz Edith (Brookline MA)
출원인 / 주소
  • Massachusetts Institute of Technology (Cambridge MA 02)
인용정보 피인용 횟수 : 50  인용 특허 : 0

초록 ▼

A system for stabilizing fibroblast-derived growth factors, maintaining their bioactivity over a prolonged period of time and controllably releasing them for use is disclosed. The system uses growth factors bound to biocompatible substrates via heparin or heparin derived compounds to maintain the bi

대표청구항

A device for controlling the release rate of a fibroblast cross-linked dextran derived growth factor which comprises a substrate material having heparin or heparin sulfate bound thereto and the growth factor bound to the heparin or heparin sulfate.

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