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Method of enhancing growth in patients using combination therapy 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-037/36
출원번호 US-0535005 (1990-06-07)
발명자 / 주소
  • Clark Ross G. (Pacifica CA) Cronin Michael J. (San Mateo CA)
출원인 / 주소
  • Genentech, Inc. (South San Francisco CA 02)
인용정보 피인용 횟수 : 68  인용 특허 : 0

초록 ▼

A method is disclosed for enhancing growth of a mammal by administration of a combination of effective amounts of IGF-I and GH so as to enhance the growth of the mammal over the enhancement in growth achieved using either IGF-I or GH alone in an amount equal to that used for either IGF-I or GH, resp

대표청구항 ▼

A method for enhancing growth of a mammal comprising administering systemically and concurrently to the mammal effective amounts of IGF-I and GH, wherein the GH is administered by injections, so as to enhance said growth of the mammal over the enhancement in growth achieved using an equivalent dose

이 특허를 인용한 특허 (68)

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  2. Shirley, Bret A.; Bajwa, Kamaljit, Compositions providing for increased IGF-I solubility.
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  3. Shirley,Bret A.; Bajwa,Kamaljit, Compositions providing for increased IGF-I solubility.
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  4. Manning,Anthony M.; Mercurio,Frank; Amit,Sharo; Ben Neriah,Yinon; Davis,Matti; Hatzubai,Ada; Yaron,Avraham; Alkalay,Irit; Ciechanover,Aaron, Compounds and methods for modulating activation of NF-κB.
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  5. Manning,Anthony M.; Mercurio,Frank; Amit,Sharo; Ben Neriah,Yinon; Davis,Matti; Hatzubai,Ada; Yaron,Avraham; Alkalay,Irit; Ciechanover,Aaron, Compounds and methods for modulating activation of NF-κB.
    상세보기
  6. Manning, Anthony M.; Mercurio, Frank; Amit, Sharon; Ben-Neriah, Yinon; Davis, Matti; Hatzubai, Ada; Yaron, Avraham; Alkalay, Irit; Ciechanover, Aaron, Compounds and methods for modulating activation of NF-κB.
    상세보기
  7. Schaffer, Michelle; Ultsch, Mark; Vajdos, Felix, Crystallization of IGF-1.
    상세보기
  8. Schaffer,Michelle; Ultsch,Mark; Vajdos,Felix, Crystallization of IGF-1.
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  9. Schaffer,Michelle; Ultsch,Mark; Vajdos,Felix, Crystallization of IGF-1.
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  10. Schaffer,Michelle; Ultsch,Mark; Vajdos,Felix, Crystallization of IGF-1.
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  11. Schaffer,Michelle; Ultsch,Mark; Vajdos,Felix, Crystallization of IGF-1.
    상세보기
  12. Schaffer,Michelle; Ultsch,Mark; Vajdos,Felix, Crystallization of IGF-1.
    상세보기
  13. Mercurio, Frank; Zhu, Hengyi; Barbosa, Miguel; Li, Jian Wu; Murray, Brion W., Double-stranded RNAS directed to IKK-2.
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  14. DiPerna, Paul M, Flow regulating stopcocks and related methods.
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  15. Sommer Andreas ; Moore Jerome A. ; Adams Steven, High dose IGF-1 therapy.
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  16. Barbara H. O'Connor ; James Q. Oeswein, Human growth hormone aqueous formulation.
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  17. O'Connor Barbara H. ; Oeswein James Q., Human growth hormone aqueous formulation.
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  18. O'Connor Barbara H. ; Oeswein James Q., Human growth hormone aqueous formulation.
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  19. Dubaquie, Yves; Fielder, Paul J.; Lowman, Henry B.; Mortensen, Deborah L., IGF-I protein variants for treating IGFBP-1-related disorders.
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  20. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
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  21. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
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  22. Michaud, Michael; Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
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  23. Michaud, Michael; Kruse, Geoffrey A., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
    상세보기
  24. Verhoef, Erik T.; DiPerna, Paul M.; Rosinko, Mike; Williamson, Mark; Kruse, Geoffrey A.; Ulrich, Thomas R.; Lamb, Phil; Saint, Sean; Michaud, Michael; Trevaskis, William, Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
    상세보기
  25. Chen, Yvonne Man-yee; Clark, Ross G.; Cochran, Andrea G.; Lowman, Henry B.; Robinson, Iain C. A. F.; Skelton, Nicholas J., Insulin-like growth factor agonist molecules.
    상세보기
  26. Chen, Yvonne Man-yee; Clark, Ross G.; Cochran, Andrea G.; Lowman, Henry B.; Robinson, Iain C. A. F.; Skelton, Nicolas J., Insulin-like growth factor agonist molecules.
    상세보기
  27. Chen, Yvonne Man-yee; Clark, Ross G.; Cochran, Andrea G.; Lowman, Henry B.; Robinson, Iain C. A. F; Skelton, Nicholas J., Insulin-like growth factor agonist molecules.
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  28. Clark Ross G. ; Lowman Henry B. ; Robinson Iain C. A. F.,GBX, Insulin-like growth factor agonist molecules.
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  29. Clark Ross G.,NZX ; Lowman Henry B. ; Robinson Iain C. A. F.,GBX, Insulin-like growth factor agonist molecules.
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  30. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  31. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  32. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  33. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  34. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  35. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  36. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  37. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  38. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  39. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  40. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  41. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  42. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C. A. F., Insulin-like growth factor agonist molecules.
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  43. Clark, Ross G.; Lowman, Henry B.; Robinson, Iain C.A.F., Insulin-like growth factor agonist molecules.
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  44. Yvonne Man-yee Chen ; Ross G. Clark NZ; Andrea G. Cochran ; Henry B. Lowman ; Iain C. A. F. Robinson ; Nicholas J. Skelton, Insulin-like growth factor agonist molecules.
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  45. Carlsson Lena Mariana Susann,SEX ; Clark Ross Graham ; Wong Wai Lee Tan, Ligand-mediated immunofunctional hormone binding protein assay method.
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  46. Clark, Ross Graham; Clark, legal representative, Gillian; Bright, George M.; Liao, Sam, Method and device for diagnosing and treating insulin-like growth factor deficiency disorders.
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  47. Shirley, Bret; Hora, Maninder; O'Hagan, Derek; Singh, Manmohan, Method for producing sustained-release formulations.
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  48. Chen, Yvonne Man-Yee; Clark, Ross G.; Cochran, Andrea G.; Dubaquie, Yves; Fielder, Paul J.; Filvaroff, Ellen; Lowman, Henry B.; Mortensen, Deborah L.; Robinson, Iain C. A. F.; Skelton, Nicholas J., Method for treating cartilage disorders.
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  50. Clark Ross G. (Pacifica CA), Method for treatment or prevention of obesity.
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  51. Clark Ross G. (Pacifica CA) Yeung Douglas A. (Fremont CA) Oeswein James Q. (Moss Beach CA), Method of formulating IGF-I with growth hormone.
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  52. Schell Jeff (Koln DEX) Logemann Jurgen (Koln DEX) Jach Guido (Koln DEX) Mundy John (Copenhagen DKX), Method of producing pathogen-resistant plants.
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  54. Clark Ross G. (Pacifica CA), Method of prophylaxis of acute renal failure.
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  55. Broderick Carol Lynn ; DiMarchi Richard Dennis ; Heiman Mark Louis ; Stramm Lawrence Edward, Method of treating insulin resistance.
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  56. LeBowitz, Jonathan, Methods and compositions for targeting proteins across the blood brain barrier.
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  57. Clark, Ross G., Methods for treatment of insulin-like growth factor-1 (IGF-1) deficiency.
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  58. Clark, Ross G., Methods for treatment of insulin-like growth factor-1 deficiency.
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  59. Clark, Ross G.; Clark, legal representative, Gillian, Methods for treatment of insulin-like growth factor-1 deficiency.
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  60. Clark, Ross G., Methods of reducing visceral fat by increasing levels of insulin-like growth factor-I (IGF-I).
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  61. Bjørn, Søren; Sørensen, Hans Holmegaard; Langballe, Peter; Larsen, Silke Møller; Ebbehøj, Kristen; Hansen, Birthe Lykkegaard, Pharmaceutical formulation.
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  62. DiPerna, Paul M., Slideable flow metering devices and related methods.
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  63. Brown, David, Solute concentration measurement device and related methods.
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  64. Mercurio,Frank; Zhu,Hengyi; Barbosa,Miguel; Li,Jian Wu; Murray,Brion W., Stimulus-inducible protein kinase complex and methods of use therefor.
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  65. Rosinko, Michael J.; Kruse, Geoffrey A.; Harris, Paul, System and method for detecting occlusions in an infusion pump.
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  66. Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Systems including vial adapter for fluid transfer.
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  67. Attie Kenneth ; Carlsson Lena M. S.,SEX ; Gesundheit Neil ; Goddard Audrey, Treatment of partial growth hormone insensitivity syndrome.
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  68. DiPerna, Paul M., Two chamber pumps and related methods.
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