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Improved probes using nucleosides containing 3-dezauracil analogs 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12P-019/34
  • C12Q-001/68
  • C07H-017/00
출원번호 US-0400205 (1989-08-29)
발명자 / 주소
  • Rogers Thomas E. (Manchester MO) Gray Steven H. (Ellisville MO) Devadas Balekudru (Chesterfield MO) Adams Steven P. (St. Charles MO)
출원인 / 주소
  • Monsanto Company (St. Louis MO 02)
인용정보 피인용 횟수 : 263  인용 특허 : 0

초록

The deazauracil containing probes of the invention are able to withstand higher temperatures, thereby allowing unmatched probes and mismatched probes to be washed off at higher hybridization stringency, thereby eliminating background readings and improving ease and accuracy of probe use.

대표청구항 ▼

A single-stranded nucleic acid probe which comprises a nucleoside residue of the formula: [Figure] in which R1 and R2 independently are C1-C5 alkyl, C2-C5 alkenyl, halo or hydrogen, R3 is hydrogen, hydroxy, C6-14 aryloxy or C1-C5 alkoxy and in which the nucleoside residue is at least five nucleoside

이 특허를 인용한 특허 (263)

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