IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0593684
(1990-10-05)
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발명자
/ 주소 |
- Cohen Smadar (Petach-Tickva ILX) Bano Carmen (Valencia PA ESX) Visscher Karyn B. (State College PA) Chow Marie (Brookline MA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA)
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| 출원인 / 주소 |
- Massachusetts Institute of Technology (Cambridge MA 02) Pennsylvania Research Corporation (University Park PA 02)
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| 인용정보 |
피인용 횟수 :
179 인용 특허 :
0 |
초록
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A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked wi
A method for encapsulating biologically-labile materials such as proteins, liposomes, bacteria and eucaryotic cells within a synthetic polymeric capsule, and the product thereof, are disclosed. The method is based on the use of a water-soluble polymer with charged side chains that are crosslinked with multivalent ions of the opposite charge to form a gel encapsulating biological material, that is optionally further stabilized by interactions with multivalent polyions of the same charge as those used to form the gel. In the preferred embodiment, hydrolytically stable polyphosphazenes are formed of monomers having carboxylic acid side groups that are crosslinked by divalent or trivalent cations such as Ca2+or Al3+, then stabilized with a polycation such as poly-L-lysine. A variety of different compositions can be formed from the crosslinked polymer. In a preferred embodiment, microcapsules are made by spraying an aqueous solution of polyphosphazene and material to be encapsulated into a calcium chloride solution. A semipermeable membrane is formed on the microspheres by complexation of the surface carboxylate groups with poly(L-lysine).
대표청구항
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A composition comprising a biological material selected from the group consisting of liposomes, viruses, procaryotic cells, and eucaryotic cells encapsulated in a microcapsule. the microcapsule a gel prepared from an ionically crosslinkable synthetic polymer, wherein the polymer is a polyelectrolyte
A composition comprising a biological material selected from the group consisting of liposomes, viruses, procaryotic cells, and eucaryotic cells encapsulated in a microcapsule. the microcapsule a gel prepared from an ionically crosslinkable synthetic polymer, wherein the polymer is a polyelectrolyte selected from the group consisting of poly(phosphazenes), poly(acrylic acids), poly(methacrylic acids), copolymers of acrylic acid or methacrylic acid and polyvinyl ethers or poly(vinyl acetate), sulfonated polystyrene, poly(vinyl amines), poly(vinyl pyridine), poly(vinyl imidazole), imino substituted polyphosphazenes, ammonium or quaternary salts and copolymers thereof, is soluble in an aqueous solution selected from the group consisting of water, aqueous alcohol, and buffered aqueous salt solutions and has charged side groups which are crosslinked by reaction of the side groups with multivalent ions of the opposite charge, wherein multivalent cations are selected from the group consisting of calcium, copper, aluminum, magnesium, strontium, barium, tin, organic cations, poly(amino acids), poly(ethyleneimine), poly(vinylamine), poly(allyl amine) and polysaccharides, and multivalent anions are selected from the group consisting of dicarboxylic acids, sulfate ions, carbonate ions, poly(acrylic acids), poly(methacrylic acids), copolymers of acrylic acid or methacrylic acid, sulfonated poly(styrene) and poly(styrene) with carboxylic acid groups, wherein the gel is insoluble in an aqueous solution after crosslinking, and has an outer membrane formed by crosslinking of the gel with a polyvalent ion of the same charge as the multivalent ions.
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