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Covalently-linked complexes and methods for enhanced cytotoxicity and imaging 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-017/02
  • C07K-007/06
  • C07K-007/08
  • C07K-007/10
  • C07K-007/34
  • C07K-007/36
  • C07K-007/38
  • A61K-049/02
출원번호 US-0390241 (1989-08-07)
발명자 / 주소
  • Anderson David C. (Seattle WA) Morgan
  • Jr. A. Charles (Edmonds WA) Abrams Paul G. (Seattle WA) Fritzberg Alan R. (Edmonds WA) Nichols Everett J. (Seattle WA)
출원인 / 주소
  • NeoRx Corporation (Seattle WA 02)
인용정보 피인용 횟수 : 206  인용 특허 : 0

초록

Covalently-linked complexes (CLCs) for targeting a defined population of cells, comprising a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety is capable of promoting CLC-target cell interaction are disclosed. Methods for using the claimed CLCs to obtain enh

대표청구항

A covalently-linked complex (CLC) for targeting a defined population of cells, comprising: a targeting protein; a cytotoxic agent; and an enhancing moiety, wherein the enhancing moiety promotes CLC-target cell interaction and exhibits alpha helical structure at acidic pH and substantially unfolds at

이 특허를 인용한 특허 (206)

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