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Systemic delivery of polypeptides through the eye 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-037/26
  • A61K-037/64
  • A61K-047/00
출원번호 US-0412979 (1989-09-26)
발명자 / 주소
  • Chiou George C. Y. (College Station TX)
출원인 / 주소
  • Orbon Corporation (Palo Alto CA 02)
인용정보 피인용 횟수 : 50  인용 특허 : 0

초록 ▼

Compositions and methods for systemic delivery of polypeptides through the eyes are disclosed. The compositions include a systemically active polypeptide at a concentration such that the composition is substantially isotonic with tear fluid. The compositions may include a permeation-enhancing agent

대표청구항 ▼

A method for delivering a polypeptide drug systemically, said method comprising: administering a therapeutically effective concentration of the drug formulated in a pharmaceutically acceptable vehicle into the eye, said concentration being less than 10% w/v and the volume of the drug formulation is

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  5. Cartt, Steve; Medeiros, David; Gwozdz, Garry Thomas; Loxley, Andrew; Mitchnick, Mark; Hale, David; Maggio, Edward T., Administration of benzodiazepine compositions.
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  6. Arnold, John Jefferson; Huang, Chun Ming; Meezan, Elias; Pillion, Dennis J.; Tang, De Chu C., Alkyl-glycoside enhanced vaccination.
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  8. Yamada Minoru (Kawanishi JPX) Heya Toshiro (Takarazuka JPX) Ogawa Yasuaki (Otokuni-gun JPX), Biodegradable high-molecular polymers, production and use thereof.
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  9. Kuo, Mei-Chang; Lechuga-Ballesteros, David, Compositions comprising an active agent.
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  22. DiPerna, Paul M.; Brown, David; Rosinko, Mike; Kincade, Dan; Michaud, Michael; Nadworny, John; Kruse, Geoffrey A.; Ulrich, Thomas R., Infusion pump system with disposable cartridge having pressure venting and pressure feedback.
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  27. Rosenkoetter Hans,DEX, Method for enhancing corneal penetration by water soluble ophthalmic drugs.
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  28. Gardner, Thomas W.; Reiter, Chad E., Method of treating a nerve-related vision disorder in a non-diabetic subject.
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  30. Gardner, Thomas W.; Reiter, Chad E., Methods of treating nerve-related vision disorders by an insulinomimetic agent.
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  46. Rosinko, Michael J.; Kruse, Geoffrey A.; Harris, Paul, System and method for detecting occlusions in an infusion pump.
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  47. Metzmaker, Thomas; Saint, Sean; Michaud, Michael; Rosinko, Michael J.; Swanson, Vance, Systems including vial adapter for fluid transfer.
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  49. Sakai Michinori,JPX ; Ohtake Hiroshi,JPX ; Azuma Hidekazu,JPX ; Otagiri Masaki,JPX ; Imai Teruko,JPX, Transmucous absorption enhancer.
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