[특허]Multifunctional thrombo-resistant coatings and methods of manufacture

Multifunctional thrombo-resistant coatings and methods of manufacture 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A01N-001/00
출원번호	US-0716843 (1991-06-17)
발명자 / 주소	Winters Suzanne (Salt Lake City UT) Solen Kenneth A. (Orem UT) Sanders Clifton G. (Salt Lake City UT) Mortensen J. D. (Sandy UT) Berry Gaylord (Salt Lake City UT)
출원인 / 주소	Cardiopulmonics, Inc. (Salt Lake City UT 02)
인용정보	피인용 횟수 : 108 인용 특허 : 0

초록 ▼

The present invention is directed to multifunctional thrombo-resistant coatings for use with biomedical devices and implants, such as a coating which includes a siloxane surface onto which a plurality of amine functional groups have been bonded. Covalently bonded to the amine functional groups are a plurality of poly(ethylene oxide) chains, such that a single poly(ethylene oxide) chain is bonded to a single amine functional group. A plurality of different bioactive molecules, designed to counteract specific blood-material incompatibility reactions, are covalently bonded to poly(ethylene oxide) chains, such that a single bioactive molecule is coupled to a single polyethylene oxide chain. The method of manufacturing the present invention include preparing a material having a siloxane surface onto which a plurality of amine functional groups have been bonded. This is achieved by plasma etching with ammonia gas or by plasma polymerization of a siloxane monomer in the presence of ammonia gas. The amine-containing siloxane surface is reacted with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine groups on the siloxane surface. The material is then reacted with a plurality of different bioactive molecules which counteract the specific blood-material incompatibility reactions, such that a single bioactive molecule is coupled to a single poly(ethylene oxide) chain. The resulting siloxane surface contains a plurality of different bioactive molecules capable of reacting with blood components which come in proximity to the siloxane surface in order to resist blood-material incompatibility reactions.

대표청구항 ▼

A method for producing a multifunctional thrombo-resistant coating for use on surfaces which contact blood, the method comprising the steps of: (a) obtained by application of one plasma etching or plasma polymerization a material having a siloxane surface onto which a plurality of amine functional groups have been bonded; (b) reacting the amine functional groups on the siloxane surface with poly(ethylene oxide) chains terminated with functional groups capable of reacting with the amine functional groups on the siloxane surface, thereby resulting in a product having single poly(ethylene oxide) chains which are bonded to corresponding single amine functional groups; (c) reacting the product of step (b) with a plurality of at least two different bioactive molecules capable of counteracting specific blood-material incompatibility reactions such that a single bioactive molecule is correspondingly coupled to a single poly(ethylene oxide) chain, thereby resulting in a siloxane surface to which are attached, by a poly(ethylene oxide) chain, a plurality of at least two different bioactive molecules which react with blood components which come in proximity to the siloxane surface of the material in order to resist blood-material incompatibility reactions.

이 특허를 인용한 특허 (108)

Falotico, Robert; Kopia, Gregory A.; Llanos, Gerard H.; Siekierka, John; Carter, Andrew J., Antiinflammatory drug and delivery device.
상세보기
David P. Balding, Automatic fever abatement system.
상세보기
Al-Lamee, Kadam Gayad, Biocompatible medical articles and process for their production.
상세보기
Kim Young Ha (Seoul KRX) Park Ki Dong (Seoul KRX) Han Dong Keun (Seoul KRX) Kim Hack Joo (Seoul KRX), Bioprosthetic heart valves having high calcification resistance.
상세보기
Pecor Robert, Catheter with coiled multi-lumen heat transfer extension.
상세보기
Blair D. Walker ; Scott M. Evans ; David P. Balding ; Gregg Hallam ; Lynn M. Shimada, Catheter with multiple heating/cooling fibers employing fiber spreading features.
상세보기
Anthony C. Aliberto ; Scott M. Evans ; William J. Worthen, Central venous catheter with heat exchange membrane.
상세보기
Lynn M. Shimada ; William J. Worthen ; Scott M. Evans ; Xia Luo ; Robert Pecor ; Blair D. Walker, Central venous catheter with heat exchange properties.
상세보기
Shimada, Lynn M.; Worthen, William J.; Evans, Scott M.; Luo, Xia; Pecor, Robert; Walker, Blair D., Central venous catheter with heat exchange properties.
상세보기
Walker, Blair D.; Evans, Scott M.; Noda, Wayne A., Central venous line catheter having multiple heat exchange elements and multiple infusion lumens.
상세보기
Meier,Ernst August; Gomez Kerber,Giancarlo; Muchorowski,Janusz; Krause,Karl Heinz; Merkmann,Gerhard, Clarification basin membrane.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D.; Osborne, Thomas A., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Voorhees, III, William D.; Kozma, Thomas G., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Voorhees, III, William D.; Kozma, Thomas G., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Voorhees, III, William D.; Kozma, Thomas G., Coated implantable medical device.
상세보기
Ragheb, Anthony O.; Bates, Brian L.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Coated implantable medical device.
상세보기
Ragheb,Anthony O.; Bates,Brian L.; Fearnot,Neal E.; Kozma,Thomas G.; Voorhees, III,William D.; Gershlick,Anthony H., Coated implantable medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Voorhees, III, William D.; Kozma, Thomas G., Coated implantable medical device method.
상세보기
Bates, Brian L.; Boatman, Scott E.; Burton, David G.; Hoffa, Michael C.; Schaeffer, Darin G.; Sturgeon, Jason S.; Ragheb, Anthony O., Coated medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Bourdeau, William J.; Fearnot, Neal E., Coated medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Stewart, IV, Joseph M.; Bourdeau, William J.; Choules, Brian D.; Purdy, James D.; Fearnot, Neal E., Coated medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Stewart, IV, Joseph M.; Bourdeau, William J.; Choules, Brian D.; Purdy, James D.; Fearnot, Neal E., Coated medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Stewart, IV, Joseph M.; Bourdeau, William J.; Choules, Brian D.; Purdy, James D.; Fearnot, Neal E., Coated medical device.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Stewart, IV, Joseph M.; Bourdeau, William J.; Choules, Brian D.; Purdy, James D.; Fearnot, Neal E., Coated medical device.
상세보기
Ragheb, Anthony O.; Bates, Brian L.; Boatman, Scott E.; Burton, David G.; Hoffa, Michael C.; Schaeffer, Darin G.; Sturgeon, Jason S., Coated medical device.
상세보기
Lentz, David Christian; Llanos, Gerard H.; Roller, Mark B.; Scopelianos, Angelo; Weadock, Kevin, Coated medical devices.
상세보기
Falotico,Robert; Spaltro,John, Coated medical devices for the treatment of vulnerable plaque.
상세보기
Delmotte,Yves, Devices and methods for mixing and extruding medically useful compositions.
상세보기
Delmotte, Yves, Devices for mixing and extruding medically useful compositions.
상세보기
Ding Ni ; Helmus Michael N., Drug coating with topcoat.
상세보기
Ding Ni ; Helmus Michael N., Drug coating with topcoat.
상세보기
Ding, Ni; Helmus, Michael N., Drug coating with topcoat.
상세보기
Ni Ding ; Michael N. Helmus, Drug release stent coating.
상세보기
Ding Ni ; Helmus Michael N., Drug release stent coating process.
상세보기
Evens,Carl J.; Weedock,Kevin, Drug releasing anastomosis devices and methods for treating anastomotic sites.
상세보기
Falotico, Robert; Siekierka, John; Llanos, Gerard H.; Kopia, Gregory A.; Carter, Andrew J., Drug/drug delivery systems for the prevention and treatment of vascular disease.
상세보기
Falotico,Robert; Kopia,Gregory A.; Llanos,Gerard H., Drug/drug delivery systems for the prevention and treatment of vascular disease.
상세보기
Pham Nora Tran ; Shimada Lynn M. ; Evans Scott M. ; Walker Blair D., Dual balloon central venous line catheter temperature control system.
상세보기
Pham, Nora Tran; Shimada, Lynn M.; Evans, Scott M.; Walker, Blair D., Dual balloon central venous line catheter temperature control system.
상세보기
Delmotte,Yves; Belot,Nathalie; Vermeulen,Pierre; Tasiaux,Nicole, Element provided with a fibrin layer, preparation and use thereof.
상세보기
Inoue, Kanji; Yagi, Takahiro; Fujita, Masaki; Kadowaki, Koji; Tanahashi, Kazuhiro, Endovascular treatment aid.
상세보기
Delmotte Yves,BEX ; Bilstad Arnold ; Amrani David ; Kennedy Mark ; DiOrio James, Fibrin delivery device and method for forming fibrin on a surface.
상세보기
Yves Delmotte BE; Arnold Bilstad ; David Amrani ; James DiOrio ; Atif M. Yardimci ; David W. Pennington ; James S. Slepicka ; Cristina Stadler, Fibrin delivery device and method for forming fibrin on a surface.
상세보기
Berry, Leslie; Andrew, Maureen, Glycosaminoglycan-antithrombin III/heparin cofactor II conjugates.
상세보기
Llanos, Gerard H.; Narayanan, Pallassana V.; Papandreou, George, Heparin barrier coating for controlled drug release.
상세보기
Van Antwerp William P., Indwelling catheter with stable enzyme coating.
상세보기
Tzeng, Elbert; Adzich, Vaso; Pompa, Hortensia; Evans, Scott M.; Barker, Peter; Worthen, William J.; Winter, Suzanne C.; Balding, David P.; Collins, Kenneth A., Indwelling heat exchange catheter.
상세보기
Noda, Wayne A.; Jones, Mike L.; Evans, Scott M.; Walker, Blair D.; Worthen, William J.; Gobin, Yves Pierre, Indwelling heat exchange catheter and method of using same.
상세보기
Noda, Wayne; Evans, Scott; Jones, Mike, Indwelling heat exchange heat pipe catheter and method of using same.
상세보기
Tzeng, Elbert; Barker, Peter; Evans, Scott M.; Noda, Wayne A., Intravascular catheter with heat exchange element having inner inflation element and methods of use.
상세보기
Baugh Robert F. (Parker CO), Lancet for capillary puncture blood samples.
상세보기
Robert F. Baugh, Lancet for capillary puncture blood samples.
상세보기
Falotico,Robert; Llanos,Gerard H., Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent.
상세보기
Falotico,Robert; Llanos,Gerard H., Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent.
상세보기
Wright,Carol; Llanos,Gerard H.; Rakos,Ronald; King,Kristin; Falotico,Robert, Local delivery of rapamycin for treatment of proliferative sequelae associated with PTCA procedures, including delivery using a modified stent.
상세보기
Llanos,Gerard H.; Lentz,David Christian, Local drug delivery devices and methods for maintaining the drug coatings thereon.
상세보기
Engelson, Erik T.; Hergenrother, Robert; Eder, Joseph, Lubricious catheters.
상세보기
Leslie Berry CA; Maureen Andrew CA, Medical device comprising glycosaminoglycan-antithrombin III/heparin cofactor II conjugates.
상세보기
Speck, Ulrich; Scheller, Bruno, Medical device for dispensing medicaments.
상세보기
Speck, Ulrich; Scheller, Bruno, Medical device for dispersing medicaments.
상세보기
Speck, Ulrich; Scheller, Bruno, Medical device for dispersing medicaments.
상세보기
Ding Ni ; Helmus Michael N., Medical devices with long term non-thrombogenic coatings.
상세보기
Davila,Luis A.; Lentz,David Christian; Llanos,Gerard H.; Mendez,Jorge Orlando; Narayanan,Pallassana V.; Pelton,Alan Roy; Roller,Mark B.; Scheidt,Karl K.; Scopelianos,Angelo George; Shaw, Jr.,William , Medical devices, drug coatings and methods for maintaining the drug coatings thereon.
상세보기
Balding, David P.; Worthen, William J., Method and apparatus for cardiopulmonary bypass patient temperature control.
상세보기
Scott M. Evans ; William J. Worthen, Method and apparatus for patient temperature control.
상세보기
Walker, Blair D.; Evans, Scott M.; Balding, David P.; Barker, Peter, Method for a central venous line catheter having a temperature control system.
상세보기
Jack W. Lasersohn ; William J. Worthen ; Scott M. Evans ; Suzanne C. Winter ; David Balding, Method for treating cardiac arrest.
상세보기
Lasersohn, Jack W.; Worthen, William J.; Evans, Scott M.; Winter, Suzanne C.; Balding, David, Method for treating cardiac arrest.
상세보기
Ding Ni, Method of applying drug-release coatings.
상세보기
Amon Michael,DEX ; Bolz Armin,DEX ; Mussig Dirk,DEX, Method of attaching heparin to, and immobilizing it on, inorganic substrate surfaces of cardiovascular implants.
상세보기
Worthen, William J.; Evans, Scott M., Method of managing patient temperature with a heat exchange catheter.
상세보기
Balding David P. ; Foster Steven Craig, Method of selectively shaping hollow fibers of heat exchange catheter.
상세보기
Ragheb,Anthony O.; Fearnot,Neal E.; Voorhees, III,William D.; Kozma,Thomas G.; Bates,Brian L.; Osborne,Thomas A., Method of treating a patient with a coated implantable medical device.
상세보기
Cahalan, Patrick; Cahalan, Linda; Johnson, Greg; Gartner, Mark, Method of treating the surface of a medical device with a biomolecule.
상세보기
Delmotte Yves,BEX ; Krack Genevieve,BEX, Method of using cross-linked fibrin material.
상세보기
Bates, Brian L.; Ragheb, Anthony O.; Fearnot, Neal E.; Kozma, Thomas G.; Voorhees, III, William D., Methods for making implantable medical devices.
상세보기
Berry,Leslie Roy; O'Brodovich, legal representative,Hugh; Chan,Anthony Kam Chuen; Andrew, deceased,Maureen, Methods of coating a device using anti-thrombin heparin.
상세보기
Mortensen, J D; Schaap, Robert N.; Bagley, Barry, Methods, apparatuses, and applications for compliant membrane blood gas exchangers.
상세보기
Mortensen, J. D; Schaap, Robert N.; Bagley, Barry, Methods, apparatuses, and applications for compliant membrane blood gas exchangers.
상세보기
Sharma, Ashok K., Organosiloxane films for gas separations.
상세보기
Glauser, Thierry; Pacetti, Stephen Dirk; Hossainy, Syed Faiyaz Ahmed; Ding, Ni, Phosphoryl choline coating compositions.
상세보기
Speck, Ulrich; Scheller, Bruno, Preparation for restenosis prevention.
상세보기
Speck, Ulrich; Scheller, Bruno, Preparation for restenosis prevention.
상세보기
Speck, Ulrich; Scheller, Brunn, Preparation for the prophylaxis of restenosis.
상세보기
Wirt David F. ; Sirvio Larry M., Process for modifying surfaces using the reaction product of a water-insoluble polymer and a polyalkylene imine.
상세보기
Cahalan, Patrick; Cahalan, Linda; Johnson, Greg; Gartner, Mark, Process for preparing a substrate coated with a biomolecule.
상세보기
Plate Nicolai A.,RUX ; Valuev Lev I.,RUX ; Uzhinova Lubov D.,RUX ; Sinani Vladimir A.,RUX, Process for preparing biologically compatible polymers and their use in medical devices.
상세보기
Hostettler Fritz (Lambertville NJ) Rhum David (New York NY) Forman Michael R. (Ramsey CA) Helmus Michael N. (St. Louis Park MN) Ding Ni (Plymouth MN), Process for producing slippery, tenaciously adhering hydrogel coatings containing a polyurethane-urea polymer hydrogel c.
상세보기
Wirt David F. ; Sirvio Lary M., Removal of biologically active agents.
상세보기
Buschmann, Wayne E., Semipermeable polymers and method for producing same.
상세보기
Alt, Eckhard, Stent device and method.
상세보기
Hussain, Ali; Cahalan, Linda; Johnson, Greg; Gartner, Mark; Cahalan, Patrick; Fill, Brian J; Speakman, Jeffrey W., Surface treated staples, sutures and dental floss and methods of manufacturing the same.
상세보기
Valint, Jr., Paul L.; Ammon, Jr., Daniel M.; McGee, Joseph A.; Grobe, III, George L.; Ozark, Richard M., Surface treatment for silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating.
상세보기
Valint, Jr., Paul L.; Ammon, Jr., Daniel M.; McGee, Joseph A.; Grobe, III, George L.; Ozark, Richard M., Surface treatment of silicone hydrogel contact lenses comprising hydrophilic polymer chains attached to an intermediate carbon coating.
상세보기
Noda, Wayne A; Evans, Scott M; Whitebook, Mark Evan; Balding, David P, System and method for controlling rate of heat exchange with patient.
상세보기
Noda,Wayne A.; Evans,Scott M.; Whitebook,Mark Evan; Balding,David P., System and method for controlling rate of heat exchange with patient.
상세보기
Trollsas, Mikael; Kleiner, Lothar W.; Hossainy, Syed F. A., Tailored aliphatic polyesters for stent coatings.
상세보기
Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
상세보기
Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
상세보기
Kunz, Lawrence L.; Anderson, Peter G., Therapeutic inhibitor of vascular smooth muscle cells.
상세보기
Glasgow,Katherine; Zerda,Adam; Dhara,Dibakar; Kumar,Vikram; Pixton,Matthew Robert, Transparent polycarbonate-polysiloxane copolymer blend, method for the preparation thereof, and article derived therefrom.
상세보기

IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Multifunctional thrombo-resistant coatings and methods of manufacture 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허를 인용한 특허 (108)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트

연합인증

Multifunctional thrombo-resistant coatings and methods of manufacture 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

전체(0) 논문(0) 특허(0) 보고서(0)

이 특허를 인용한 특허 (108)

관련 콘텐츠

특허 원문 보기

IPC 상위 출원인

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

선택된 텍스트