[특허]Controlled administration of chemodenervating pharmaceuticals

Controlled administration of chemodenervating pharmaceuticals 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-031/00
출원번호	US-0570395 (1990-08-21)
발명자 / 주소	Borodic Gary E. (Canton MA)
출원인 / 주소	Associated Synapse Biologics (Boston MA 02)
인용정보	피인용 횟수 : 78 인용 특허 : 0

초록 ▼

This invention relates to a method for controlled administration of chemodernervating agents such as botulinum toxin-derived pharmaceutical, useful in attenuating neural stimulation and spasmotic activity of muscle. The method involves administration of novel dosage forms based upon the standardization of denervating pharmaceuticals. The invention also relates to novel methods of administering chemodernervating agents in a controlled and reproducible manner so as to confine their effects to a given region of muscle mass while minimizing paresis in adjacent muscle tissue.

대표청구항 ▼

A method of standardizing dosages of a chemodenervating preparation by relating extent of denervation in a muscle or muscle group of an experimental animal to a unit quantity of said preparation comprising the steps of injecting a unit quantity of said preparation into said muscle or muscle group of an experimental animal, permitting said preparation to diffuse within said muscle or muscle group about the site of said injection and to physiologically inhibit acetylcholine release, and determining the spatial extent of inhibition of acetylcholine release about the site of injection within said muscle or group per said unit quantity of said preparation, thereby providing a reliable indicator to a clinician of a volume of said muscle or muscle group which is denervated by a quantity of said preparation.

이 특허를 인용한 특허 (78)

Borodic, Gary E., Anti-inflammatory topical botulinum toxin composition.
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Donovan, Stephen, Biodegradable botulinum toxin implant.
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Stephen Donovan ; Daniel G. Brady, Biodegradable neurotoxin implant.
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Singh, Bal Ram; Sharma, Shashi Kant, Biologically active hemagglutinin from type A and methods of use.
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Singh, Bal Ram; Sharma, Shashi Kant, Biologically active hemagglutinin from type a Clostridium botulinum and methods of use.
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Walker, Patricia S., Botulinum toxin administration to treat various conditions.
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Walker, Patricia S., Botulinum toxin administration to treat various conditions.
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Walker,Patricia S., Botulinum toxin for treating postherpetic neuralgia.
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Graham,Herbert Kerr, Botulinum toxin neurotoxic component for treating juvenile cerebral palsy.
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Aoki, Kei Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Botulinum toxin treatments.
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Borodic, Gary E., Chemodenervating pharmaceutical as anti-inflammatory agent.
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Pearce L. Bruce ; First Eric R., Compositions and methods for chemodenervation using neurotoxins.
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Ruegg, Curtis L.; Stone, Hongran Fan; Waugh, Jacob M., Compositions and methods for safe treatment of rhinitis.
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Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
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Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
상세보기
Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
상세보기
Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
상세보기
Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
상세보기
Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
상세보기
Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
상세보기
Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for surface abrasion with frozen particles.
상세보기
Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
상세보기
Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
상세보기
Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
상세보기
Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
상세보기
Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
상세보기
Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
상세보기
Boyden, Edward S.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Compositions and methods for therapeutic delivery with frozen particles.
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Donovan, Stephen; Brady, Daniel G., Controlled release neurotoxin system.
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Gary E. Borodic, Cytotoxin (non-neurotoxin) for the treatment of human headache disorders and inflammatory diseases.
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Koman, L. Andrew, Dose and localization of botulinum toxins in skin and muscle.
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Koman, L. Andrew, Dose and localization of botulinum toxins in skin and muscle.
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Hott, Jonathan S.; Youle, Richard J.; Hallett, Mark; Dalakas, Marinos C., Immunotoxin (mAB-RICIN) for the treatment of focal movement disorders.
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Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Method and system for comparing tissue ablation or abrasion data to data related to administration of a frozen particle composition.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Method for treating a cholinergic influenced sweat gland.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Method for treating cervical dystonia with botulinum toxin type B.
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Aoki K. Roger ; Grayston Michael W. ; Carlson Steven R. ; Leon Judith M., Method for treating dystonia with botulinum toxin type B.
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Aoki K. Roger ; Grayston Michael W. ; Carlson Steven R. ; Leon Judith M., Method for treating dystonia with botulinum toxin types C to G.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Method for treating essential tremor with botulinum toxin type B.
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K. Roger Aoki ; Michael W. Grayston ; Steven R. Carlson ; Judith M. Leon, Method for treating headache.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Method for treating muscle spasm with botulinum toxin type B.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Method for treating neuromuscular disorders and conditions with botulinum toxin types A and B.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Method for treating pain with botulinum toxin type B.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Method for treating secretions and glands using botulinum toxin.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Method for treating tardive dyskinesia with Botulinum toxin type B.
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Arnon Stephen S. (9 Fleetwood Ct. Orinda CA 94563), Method to prevent side-effects and insensitivity to the therapeutic uses of toxins.
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Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L., Methods and systems for ablation or abrasion with frozen particles and comparing tissue surface ablation or abrasion data to clinical outcome data.
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Brin, Mitchell F.; Donovan, Stephen, Methods for breast treatment.
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Aoki,K. Roger; Grayston,Michael W.; Carlson,Steven R.; Leon,Judith M., Methods for treating arthritis pain.
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Brin, Mitchell F.; Donovan, Stephen, Methods for treating diverse cancers.
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Brin, Mitchell F.; Donovan, Stephen, Methods for treating mammary gland disorders.
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Aoki,K. Roger; Grayston,Michael W.; Carlson,Steven R.; Leon,Judith M., Methods for treating myofascial pain.
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Aoki,Kei Roger; Grayston,Micheal W.; Carlson,Steven R.; Leon,Judith M., Methods for treating pain associated with arthritis.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Methods for treating tension headache.
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Walker,Patricia S., Methods of administering botulinum toxin.
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Donovan Stephen ; Brady Daniel G., Neurotoxin implant.
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Holland,James M.; Chow,Edward, Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles.
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Holland,James M.; Chow,Edward, Nuclei density and nuclei area methods for determining effects of a botulinum toxin on muscles.
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Moyer, Elizabeth; Hirtzer, Pamela, Stable liquid formulations of botulinum toxin.
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Moyer,Elizabeth; Hirtzer,Pamela, Stable liquid formulations of botulinum toxin.
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Hanin,Lisa D., Surface topography method for determining effect of a botulinum toxin upon a muscle.
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Hanin,Lisa D.; Brooks,Gregory F., Surface topography method for determining effects of a botulinum toxin upon a muscle and for comparing botulinum toxins.
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Wilson, Nestor Antonio Lagos, Transdermal administration of phycotoxins.
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Aoki, Kei Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Treatment for cervical dystonia with the neurotoxic component of a botulinum toxin.
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Lagos Wilson, Nestor Antonio, Use and application of a pharmaceutical composition containing a mixture of natural-origin heterocyclical guanidine.
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Wilson, Nestor Antonio Lagos, Use and application of a pharmaceutical composition containing a mixture of natural-origin heterocyclical guanidine, for cosmetology, wound healing, focal dystonia and muscular spasm- related clinical pathologies.
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Wilson, Nestor Antonio Lagos, Use and application of a pharmaceutical composition containing a mixture of natural-origin heterocyclical guanidine, for cosmetology, wound healing, focal dystonia and muscular spasm-related clinical pathologies.
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Schmidt, Richard A., Use of botulinum toxin therapy for treatment of recalcitrant voiding dysfunction.
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Schmidt,Richard A., Use of botulinum toxin therapy for treatment of recalcitrant voiding dysfunction.
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Schmidt, Richard A., Use of botulinum toxin therapy for treatment of urological neurological conditions.
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Aoki, K. Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Use of botulinum toxins for treating various disorders and conditions and associated pain.
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Schmidt, Richard A, Use of neurotoxin therapy for treatment of urologic and related disorders.
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Schmidt, Richard A, Use of neurotoxin therapy for treatment of urologic and related disorders.
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Schmidt, Richard A., Use of neurotoxin therapy for treatment of urologic and related disorders.
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Allen, legal representative,David; Schmidt,Richard A., Use of neurotoxin therapy for treatment of urologic and related disorders related to lowering elevated bladder pressure.
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Schmidt,Richard A., Use of neurotoxin therapy for treatment of urologic and related disorders related to neurogenic bladder dysfunction.
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, Use of neurotoxin therapy for treatment of urological-neurological disorders associated with prostate cancer.
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Aoki, Kei Roger; Grayston, Michael W.; Carlson, Steven R.; Leon, Judith M., Use of the neurotoxic component of a botulinum toxin for treating a spastic muscle.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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연합인증

Controlled administration of chemodenervating pharmaceuticals 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허를 인용한 특허 (78)

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Controlled administration of chemodenervating pharmaceuticals 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

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이 특허를 인용한 특허 (78)

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