An immunity analysis apparatus for use with magnetic particles in which a sample is transferred to a reaction vessel and the reaction vessel is conveyed past several devices for adding and agitating a magnetic particle solution, adding a stroma solution, absorbing the particles to an inner wall of t
An immunity analysis apparatus for use with magnetic particles in which a sample is transferred to a reaction vessel and the reaction vessel is conveyed past several devices for adding and agitating a magnetic particle solution, adding a stroma solution, absorbing the particles to an inner wall of the reaction vessels to remove the reaction solution, adding an enzyme labelling antibody solution, absorbing the particle on an inner wall a second time to remove the resulting solution, adding a stop solution, measuring the result, and cleaning the reaction vessels for a reuse. The device additionally has structure for agitating the magnetic particle reagent solution containers and moving a pipet arm independent of an L-shaped agitating rod arm during a portion of its movement to supply the reaction vessels with the magnetic particle solution.
대표청구항▼
An automatic immunity analysis apparatus comprising reaction vessels arranged in a series, a conveying means for said reaction vessels, a first dividing means for sucking a sample in a predetermined quantity at a predetermined position and dividing and charging said sample into each of said reaction
An automatic immunity analysis apparatus comprising reaction vessels arranged in a series, a conveying means for said reaction vessels, a first dividing means for sucking a sample in a predetermined quantity at a predetermined position and dividing and charging said sample into each of said reaction vessels, a first agitating means for dividing, charging and agitating an antibody insoluble magnetic solution into each of said reaction vessels containing said sample divided and charged, a second dividing means which is positioned after said first agitating means, said second dividing means for dividing and charging a stroma solution into each of said vessels, a first adsorbing means for adsorbing said antibody insoluble magnetic solution onto an inner wall surface of each of said reaction vessels, a first cleaning means for discarding a reactions solution out of each of said reaction vessels while said antibody insoluble magnetic solution is still adsorbed on the inner wall of each of said reaction vessels and then cleaning each of said vessels, a second agitating means for dividing and agitating an enzyme labeling antibody solution, a second absorbing means for adsorbing said antibody insoluble magnetic solution onto an inner wall surface of each of said reaction vessels, a second cleaning means for discarding a reaction solution out of each of said reaction vessels while said antibody insoluble magnetic solution is still adsorbed on the inner wall of each of said reaction vessels and then cleaning each of said vessels, a third dividing means for dividing and charging a reaction stop solution, a measuring means for optically measuring a sample in each of said reaction vessels at an optical measuring position, and a third cleaning means for cleaning the inside of each of said reaction vessels after completion of a measurement, wherein said first dividing means, said first agitating means, said second dividing means, said first adsorbing means, said first cleaning means, said second agitating means, said second absorbing means, said second cleaning means, said third dividing means, said measuring means and said third cleaning means are arranged sequentially beginning with said first dividing means and ending with said third cleaning means on said conveying means in said automatic immunity analysis apparatus, wherein said first agitating means further comprises a reagent vessel holder which is rotated by means of a driving apparatus, a rotating body which is engaged with a retention hole of said reagent vessel holder in a freely rotatable manner and has an aperture in a side surface, a fixed gear body having a first peripheral surface of which gear teeth are cut thereon, said fixed gear body mounted on said reagent vessel holder, a gear body which engages with the gear teeth of said fixed gear body and drives said rotating body when said reagent vessel holder rotates, said fixed gear body further including protrusion bodies which are elevated in predetermined intervals along a second peripheral surface of said fixed gear body, said protrusion bodies extending through said aperture during driving of said rotation body, wherein an antibody insoluble magnetic solution accommodated in said rotating body is rotated and agitated when said reagent vessel holder revolves, and accommodated in said rotating body in such a manner that said reagent antibody insoluble magnetic solution is shaken and agitated by one of said protrusion bodies extending through said aperture.
Acosta Galo F. ; Bransky Jeffrey D. ; Case Robert ; Foster Gregory J. ; Myers Kristi K. ; Shimei Thomas M. ; Woodhead Andrew J.,GBX, Assay work station.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Automated analyzer for performing a nucleic acid-based assay.
Carey Glen A. (Grafton OH) Lewis Scott C. (Amherst OH) Mann Raymond A. (Kipton OH) Whitesel Mary B. (Grafton OH) Polaniec James P. (North Ridgeville OH) Woyansky George J. (Westlake OH) Pabst Stefan , Automated analyzer with reagent agitating device.
Babson Arthur L. ; Palmieri Thomas ; Montalbano Anthony P. ; Montalbano Chris P. ; Montalbano Greg A. ; Fleischer Eric C., Automated immunoassay analyzer.
Babson Arthur L. ; Palmieri Thomas ; Montalbano Anthony P. ; Montalbano Chris P. ; Montalbano Greg A. ; Fleischer Eric C., Automated immunoassay analyzer.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Automated process for detecting the presence of a target nucleic acid in a sample.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Automated process for detecting the presence of a target nucleic acid in a sample.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Automated process for detecting the presence of a target nucleic acid in a sample.
Ammann,Kelly G.; Burns,Ralph E.; Hansberry,Ernest V.; Horner,Glenn A.; Jakub,Cheryl A.; Kling,John E.; Nieglos,Donald J.; Schneider,Robert E.; Smith,Robert J., Automated process for detecting the presence of a target nucleic acid in a sample.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Automated process for isolating and amplifying a target nucleic acid sequence.
Carey Glen A. (Grafton OH) Lewis Scott C. (Amherst OH) Mann Raymond A. (Kipton OH) Whitesel Mary Beth (Grafton OH) Polaniec James P. (North Ridgeville OH) Woyansky George J. (Westlake OH) Pabst Stefa, Constant luminescence source module for an automated analyzer.
Lair, Gary D.; Nguyen, Thanh N.; Li, Haitao; Li, Florence; Knight, Byron J.; Heinz, Robert E.; Macioszek, Jerzy A.; Davis, Christopher B.; Scalese, Robert F., Continuous process for performing multiple nucleic acid amplification assays.
Bibette, Jèrôme; Nerin, Philippe; Gineys, Jean-Philippe; Cauet, Gilles, Device and method for carrying out haematological and biochemical measurements from a biological sample.
Fuchs, Benjamin C.; Hoffmann, Christian; Keller, Karsten; Rey, Christopher M., Magnetic field and field gradient enhanced centrifugation solid-liquid separations.
Tajima Hideji,JPX, Magnetic material attracting/releasing control method making use of a pipette device and various types of analyzer using the method.
Tajima Hideji,JPX, Magnetic material attracting/releasing control method making use of a pipette device and various types of analyzer using the method.
Tajima Hideji,JPX, Magnetic material attracting/releasing control method making use of a pipette device and various types of analyzer using the method.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method and apparatus for performing a magnetic separation purification procedure on a sample solution.
Kegelman Joseph Edward ; Mizzer John Paul ; Nuzzaci Edward Anthony ; Chow Allan Tit-Shing, Method and apparatus for pre-treating samples in an automatic chemical analyzer.
Bushnell Steven E. ; Garyantes Tina K. ; Malek Michael L. ; Kirchick Howard J., Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using ma.
Bendele Teresa M. ; Harrison Linda A. ; Howard David J. ; Knotts Lori K. ; Malek Michael L. ; Veverka Todd A., Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using magnetic separation technology.
Ammann, Kelly G.; Schneider, Robert E.; Smith, Robert J., Method for agitating the contents of a reaction receptacle within a temperature-controlled environment.
Macioszek, Jerzy A.; Davis, Christopher B.; Lair, Gary D.; Nguyen, Thanh N.; Li, Haitao; Li, Florence F.; Knight, Byron J.; Scalese, Robert F.; Heinz, Robert E., Method for continuous mode processing of the contents of multiple reaction receptacles in a real-time amplification assay.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for detecting the presence of a nucleic acid in a sample.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for detecting the presence of a nucleic acid in a sample.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for detecting the presence of a nucleic acid in a sample.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for detecting the presence of a nucleic acid in a sample.
Arnquist David C. ; Barnes ; III Grady ; Button Richard D. ; Dunn Chadwick M. ; East ; Jr. Richard C. ; Fritchie Patrick P. ; Galitz Charles M. ; Gardner Gregory E. ; Grandone Cass J. ; Gray Robert C, Method for determination of item of interest in a sample.
Ammann, Kelly G.; Schneider, Robert E.; Smith, Robert J., Method for introducing a fluid into a reaction receptacle contained within a temperature-controlled environment.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for performing an assay with a nucleic acid present in a specimen.
Macioszek, Jerzy A.; Davis, Christopher B.; Lair, Gary D.; Nguyen, Thanh N.; Li, Haitao; Li, Florence F.; Knight, Byron J.; Scalese, Robert F.; Heinz, Robert E., Method for performing multi-formatted assays.
Ammann, Kelly G.; Burns, Ralph E.; Hansberry, Ernest V.; Horner, Glenn A.; Jakub, Cheryl A.; Kling, John E.; Nieglos, Donald J.; Schneider, Robert E.; Smith, Robert J., Method for simultaneously performing multiple amplification reactions.
Arnquist David C. ; Barnes ; III Grady ; Dunn Chadwick M. ; East ; Jr. Richard C. ; Fritchie Patrick P. ; Gardner Gregory E. ; Grandone Cass J. ; Gray Robert C. ; Holen James T. ; McCoy Jimmy D. ; Mi, Method of performing a process for determining an item of interest in a sample.
Knight, Byron J.; Opalsky, David; Schroeter, Brian, Method, system and apparatus for incorporating capacitive proximity sensing in an automated fluid transfer procedure.
Müller, Hans-Jürgen; Drescher, Bernd; Mann, Karl-Heinz, Reagent cartridge with a reagent container for a particle-charged reagent, for non-invasive homogenization of the latter.
Beri Cohen ; Thomas W. DeYoung ; Krunoslav Esteban Draganovic ; Lev Vant ; Richard S. Antoszewski ; Joseph J. Zelezniak ; Edward R. Sieger, Jr., Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics.
Cohen Beri ; DeYoung Thomas W. ; Draganovic Krunoslav Esteban ; Vant Lev ; Antoszewski Richard S. ; Zelezniak Joseph J. ; Sieger ; Jr. Edward R., Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics.
Cohen Beri ; DeYoung Thomas W. ; Draganovic Krunoslav Esteban ; Vant Lev ; Antoszewski Richard S. ; Zelezniak Joseph J. ; Sieger ; Jr. Edward R., Robotics for transporting containers and objects within an automated analytical instrument and service tool for servicing robotics.
Londo, Thomas R.; Grippo, Paul M.; Sylva, Frank; Schelberg, Charles; Finkelstein, Jeff; Lyons, Mark, Sampling probe, gripper and interface for laboratory sample management systems.
Lair, Gary D.; Nguyen, Thanh N.; Li, Haitao; Li, Florence F.; Knight, Byron J.; Heinz, Robert E.; Macioszek, Jerzy A.; Davis, Christopher B.; Scalese, Robert F., Signal measuring system having a movable signal measuring device.
Arnquist, David C.; Barnes, III, Grady; Button, Richard D.; Dunn, Chadwick M.; East, Jr., Richard C.; Fritchie, Patrick P.; Galitz, Charles M.; Gardner, Gregory E.; Grandone, Cass J.; Gray, Robert C., Structure for determination of item of interest in a sample.
Acosta, Galo F.; Bransky, Jeffrey D.; Case, Robert; Foster, Gregory J.; Myers, Kristi K.; Shimei, Thomas M.; Woodhead, Andrew J., Substance transfer device.
Lair, Gary D.; Nguyen, Thanh N.; Li, Haitao; Li, Florence F.; Knight, Byron J.; Heinz, Robert E.; Macioszek, Jerzy A.; Davis, Christopher B.; Scalese, Robert F., System for performing multi-formatted assays.
Heinz, Robert E.; Newell, Dennis; Opalsky, David; Rhubottom, Jason, Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector.
Heinz, Robert E.; Newell, Dennis; Opalsky, David; Rhubottom, Jason, Systems and methods for distinguishing optical signals of different modulation frequencies in an optical signal detector.
Jacobs, Merrit N.; Skrobach, Ann M.; Foote, Andrew S.; Machulskis, Anthony C., Wash process for removing undesired components in samples being analyzed.
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