[특허]Adhesive transdermal dosage layer

Adhesive transdermal dosage layer 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-013/00
출원번호	US-0744632 (1991-08-07)
발명자 / 주소	Sablotsky Steven (Miami FL) Questel John M. (Cuyahoga Falls OH) Thompson James A. (Akron OH)
출원인 / 주소	Key Pharmaceuticals, Inc. (Kenilworth NJ 02)
인용정보	피인용 횟수 : 61 인용 특허 : 0

초록 ▼

An adhesive bilayer transdermal dosage system capable of sustained release of a pharmaceutically active drug to the skin of a human patient having a first component layer which is a pharmaceutically active drug-containing essentially planar sheet of an at least partially cross-linked acrylic adhesive. The planar sheet is formed of a flexible self-supporting cross-linked acrylate of sufficient adhesivity, durability and strength whereby intimate diffusional contact with the skin of the patient is maintained for a period of at least about 24 hours without destruction of the physical integrity of the sheet. The sheet is capable of retaining, dispersed therein, sufficient pharmaceutically active drug to deliver to the skin a pharmaceutically effective amount of the drug over a 24-hour period without dissolution of the at least partially crosss-linked acrylic adhesive. The system also contains a second component layer intimately adhered to one side of the first component layer. The second component layer is resistant to the passage of the pharmaceutically active drug from the first component layer. Methods for making the first component layer and dosage system are also disclosed.

대표청구항 ▼

An adhesive bilayer transdermal dosage system for the sustained release of nitroglycerin to the skin of a human patient, comprising: (i) a first component layer formed of a nitroglycerin-containing essentially planar sheet of an at least partially cross-linked acrylic pressure-sensitive adhesive, said essentially planar sheet comprising a flexible self-supporting cross-linked acrylate polymer of sufficient adhesivity, durability and strength whereby intimate diffusional contact with skin of the patient is maintained for a period of at least about 24 hours without destruction of the physical integrity of said sheet, said essentially planar sheet being capable of retaining dispersed therein sufficient nitroglycerin to deliver to the skin a pharmaceutically effective amount of said nitroglycerin over a 24-hour time interval, without dissolution of the at least partially cross-linked acrylic pressure-sensitive adhesive and (ii) a second component layer intimately adhered to one side of said first component layer, said second component layer being resistant to the passage of pharmaceutically active drug from said first component layer; wherein said first component layer comprises about 40 to about 80% by weight of acrylic adhesive; wherein said acrylic adhesive comprises about 1 to about 5% by weight of acrylic acid and about 5 to about 20% by weight of a C4 to C12 alkyl acrylate; about 20 to about 60% by weight of nitroglycerin; about 0.2 to about 1% of a cross-linking agent and 10% or less of water.

이 특허를 인용한 특허 (61)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Adhesive transdermal dosage layer 원문보기

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Adhesive transdermal dosage layer 원문보기

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