[특허]Implantable drug delivery system with piston acutation

Implantable drug delivery system with piston acutation 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/22
출원번호	US-0716926 (1991-06-18)
발명자 / 주소	Hanover Barry K. (Salt Lake City) Jacobsen Stephen C. (Salt Lake City) Simon Eric M. (Salt Lake City) Petelenz Tomasz (Salt Lake City) Mladejovsky Michael G. (Murray UT)
출원인 / 주소	University of Utah Research Foundation (Salt Lake City UT 02)
인용정보	피인용 횟수 : 58 인용 특허 : 0

초록 ▼

An implantable drug delivery system includes a housing having a base end and a discharge end, for holding drug solution at the discharge end, a valve disposed at the discharge end to allow a drug solution to flow from inside the housing, through the valve and out of the housing when solution pressure is applied to the valve, a piston slidably disposed in the housing to slide between the base end and discharge end to force solution toward the discharge end and out the valve, and a spring disposed in the housing between the piston and the base end thereof for urging the piston toward the discharge end. A plurality of different length tethers are connected at one end to the piston and at the other end to a respective release node located at the base end of the housing. Each release node holds the other end of a respective one of the tethers until a release signal is received at which time it releases the tether. A timing circuit is disposed in the housing at the base end to supply release signals sequentially to the nodes in order of the shortest tether node to the longest tether node so that as a tether is released, the piston is allowed to move toward the discharge end of the housing to thereby discharge or bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston.

대표청구항 ▼

An implantable drug delivery system comprising a housing having a base end and a discharge end for holding drug solution at the discharge end, valve means disposed at the discharge end of the housing to allow the drug solution to flow out of the valve means and out of the housing when the drug solution pressure is applied to the valve means, piston means slidably disposed in the housing to slide between the base end and discharge end to force the drug solution toward the discharge end and out the valve means, biasing means for urging the piston means toward the discharge end of the housing, movement control means, connected to the piston means, for allowing successive step-wise movement of the piston means toward the discharge end of the housing in response to a plurality of release signals, and for otherwise restraining movement of the piston means, wherein said movement control means comprises a plurality of different length tethers each having a first and second end, the different length tethers being connected at a first end to the piston means, a plurality of release nodes located in the housing near the base end thereof, each for holding the second end of a different one of the tethers and for releasing said second end in response to a release signal, and means for supplying release signals in a predetermined sequence to said movement control means wherein said release signal supplying means comprises means for sequentially supplying release signals to the release nodes in the order of the shortest tether node to the longest tether node so that as a tether is released, the piston means is moved toward the discharge end of the housing to thereby discharge a bolus of drug solution from the housing, until the next shortest unreleased tether stops further movement of the piston means.

이 특허를 인용한 특허 (58)

Jacobsen Stephen C. ; Zentner Gaylen M., Apparatus for automatic administration of multiple doses of drugs.
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Gillis, Edward M.; Poutiatine, Andrew L.; Filice, James A.; Wickman, Peter; Culwell, John; Dinka, John S., Device and method for accurate delivery of an active agent.
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Joshi, Ashok V.; Wold, Truman; McEvoy, John J., Device employing gas generating cell for facilitating controlled release of fluid into ambient environment.
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Gordon, John Howard; Joshi, Ashok V., Device for delivery of volatile liquids to gaseous environment utilizing a gas generating cell.
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Jacobsen Stephen C. ; Best Aaron M. ; Petelenz Tomasz J., Disposable automatic injection device.
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Jacobsen Stephen C. ; Best Aaron M. ; Petelenz Tomasz J. ; Sinnott M. Mary, Disposable fluid injection module.
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Santini ; Jr. John T. ; Cima Michael J. ; Langer Robert S., Fabrication of microchip drug delivery devices.
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Joshi Ashok V. ; Palma Giorgio di ; Wold Truman, Gas generating device for delivering beneficial agents to a body cavity.
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Wold, Truman; Gordon, John Howard; Joshi, Ashok, Gas generation dispenser apparatus and method for on-demand fluid delivery.
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Wold, Truman; Gordon, John Howard; Joshi, Ashok V., Gas generation dispenser method for on-demand fluid delivery.
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Uhland,Scott A.; Polito,Benjamin F.; Herman,Stephen J.; Santini, Jr.,John T.; Maloney,John M., Hermetically sealed microchip reservoir devices.
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Uhland,Scott A., Implantable drug delivery device.
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Adamis, Anthony P.; Miller, Joan W.; Gragoudas, Evangelos S.; Mescher, Mark J.; Dubé, Christopher E.; Borenstein, Jeffrey T.; Weinstein, Marcie G.; Miller, Raanan A.; Hansberry, Mitchell L., Implantable drug delivery device and use thereof.
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Santini, Jr., John T.; Hutchinson, Charles E., Implantable drug delivery stents.
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Houzego, Peter J.; Morgan, Peter N.; Hirst, Peter H.; Westland, Duncan J.; Wilding, Ian R., Ingestible device.
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Houzego,Peter J.; Morgan,Peter N.; Hirst,Peter H.; Westland,Duncan J.; Wilding,Ian R., Ingestible device.
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Santini, Jr.,John T.; Sheppard, Jr.,Norman F., Medical device and method for diagnostic sensing.
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Santini, Jr., John T.; Herman, Stephen J., Medical device for sensing glucose.
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Santini, Jr., John T.; Sheppard, Jr., Norman F.; Young, Chung Chang; Langer, Robert S., Medical device with reservoir-based sensors.
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Jacobsen Stephen C. ; Zentner Gaylen M., Method for automatic dosing of drugs.
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Jacobsen Stephen C. ; Zentner Gaylen M., Method for automatic dosing of drugs.
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Santini, Jr., John T.; Sheppard, Jr., Norman F.; Langer, Robert S.; Young, Chung Chang, Method for making reservoir-based sensor device.
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Santini, Jr., John T.; Sheppard, Jr., Norman F.; Langer, Robert S.; Young, Chung Chang, Method for operating a reservoir-based sensor device.
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Santini, Jr., John T.; Cima, Michael J.; Langer, Robert S.; Ausiello, Dennis; Sheppard, Jr., Norman F., Method of actuating implanted medical device.
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Santini, Jr., John T.; Cima, Michael J.; Langer, Robert S.; Göpferich, Achim, Method of controlled drug delivery from implant device.
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Santini, Jr., John T.; Cima, Michael J.; Langer, Robert S.; Ausiello, Dennis; Sheppard, Jr., Norman F., Method of opening reservoir of containment device.
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Shawgo, Rebecca S.; Sheppard, Jr., Norman F.; Cima, Michael J.; Santini, Jr., John T.; Herman, Stephen J.; Polito, Benjamin F.; Uhland, Scott A., Methods and devices for sealing microchip reservoir devices.
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Sheppard, Jr., Norman F.; Feakes, Christina M., Methods for conformal coating and sealing microchip reservoir devices.
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Uhland, Scott A.; Polito, Benjamin F.; Herman, Stephen J.; Santini, Jr., John T.; Maloney, John M., Methods for hermetically sealing microchip reservoir devices.
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Coppeta, Jonathan R.; Santini, Jr., John T.; Uhland, Scott A., Micro-reservoir osmotic release systems and microtube array device.
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Santini, Jr.,John T.; Cima,Michael J.; Langer,Robert S., Microchip drug delivery devices.
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John T. Santini, Jr. ; Charles E. Hutchinson ; Scott A. Uhland ; Michael J. Cima ; Robert S. Langer ; Dennis Ausiello, Microfabricated devices for the delivery of molecules into a carrier fluid.
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Santini, Jr., John T.; Hutchinson, Charles E.; Uhland, Scott A.; Cima, Michael J.; Langer, Robert S.; Ausiello, Dennis, Microfabricated devices for the delivery of molecules into a carrier fluid.
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Santini, Jr., John T.; Sheppard, Jr., Norman F.; Young, Chung Chang; Langer, Robert S., Microfabricated devices for the storage and selective exposure of chemicals and devices.
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Santini, Jr., John T.; Sheppard, Jr., Norman F.; Young, Chung Chang; Langer, Robert S., Microfabricated devices for the storage and selective exposure of chemicals and devices.
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Santini, Jr., John T.; Sbiaa, Zouhair; Coppeta, Jonathan R.; Uhland, Scott A.; Sheppard, Jr., Norman F., Multi-cap reservoir devices for controlled release or exposure of reservoir contents.
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Santini, Jr., John T.; Sbiaa, Zouhair; Coppeta, Jonathan R.; Uhland, Scott A.; Sheppard, Jr., Norman F., Multi-opening reservoir devices for controlled release or exposure of reservoir contents.
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Santini, Jr., John T.; Staples, Mark A.; Herman, Stephen J., Multi-reservoir device for transdermal drug delivery and sensing.
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Jacobsen Stephen C. ; Wyatt Roland ; Peterson Stephen C. ; Petelenz Tomasz J., Multipathway electronically-controlled drug delivery system.
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Jacobsen Stephen C. ; Wyatt Roland ; Peterson Stephen C. ; Petelenz Tomasz J., Multipathway electronically-controlled drug delivery system.
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Santini, Jr.,John T.; Hutchinson,Charles E., Stent for controlled release of drug.
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Michael J. Badalamenti ; Mark A. Sedlack, Teething gel applicator with cutter, and burstable ampule and method of making the same.
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Petrakis,Dennis N., Temperature activated systems.
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Petrakis,Dennis N., Temperature activated systems.
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Petrakis,Dennis N., Temperature activated systems.
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Petrakis, Dennis N., Temperature responsive systems.
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Petrakis, Dennis N., Temperature responsive systems.
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Petrakis, Dennis N., Temperature responsive systems.
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Petrakis,Dennis N., Temperature responsive systems.
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Petrakis,Dennis N., Temperature responsive systems.
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Santini, Jr., John T.; Cima, Michael J.; Uhland, Scott Albert, Thermally-activated microchip chemical delivery devices.
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Santini, Jr., John T.; Cima, Michael J.; Uhland, Scott Albert, Thermally-activated microchip chemical delivery devices.
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Santini, Jr.,John T.; Cima,Michael J.; Uhland,Scott Albert, Thermally-activated reservoir devices.
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Jacobsen Stephen C. ; Davis Clark, Topical drug dispersing apparatus.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Implantable drug delivery system with piston acutation 원문보기

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Implantable drug delivery system with piston acutation 원문보기

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이 특허를 인용한 특허 (58)

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