IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0802723
(1991-12-05)
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발명자
/ 주소 |
- McAfee Donald A. (Richmond VA)
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| 출원인 / 주소 |
- Whitby Research, Inc. (Richmond VA 02)
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| 인용정보 |
피인용 횟수 :
31 인용 특허 :
0 |
초록
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Melatonin compounds are disclosed of the formula [Figure] where R is hydrogen or C1 to C6 linear or branched alkylene substituted with phenyl; R1 is hydrogen, substituted benzyl, naphthylmethyl or taken together with R2 and the two carbon atoms of the five-membered hetero ring form the group [Figure
Melatonin compounds are disclosed of the formula [Figure] where R is hydrogen or C1 to C6 linear or branched alkylene substituted with phenyl; R1 is hydrogen, substituted benzyl, naphthylmethyl or taken together with R2 and the two carbon atoms of the five-membered hetero ring form the group [Figure] where R1′is C1 to C6 linear or branched alkanoyl and R1″is hydrogen, C1 to C6 linear or branched alkyl or phenyl optionally substituted with one or more halogen, amino, nitro, hydroxy, alkyl, alkoxy or haloalkyl; R2 is hydrogen, 1-pyrrolyl, 1-pyrrolyl substituted with one or more alkyl or alkoxy, the group －(CH2)m－NHR2′1, where m is 1 to 3 and R2′is phenyl sulfonyl, the phenyl group optionally substituted with alkyl, or －C(O)－R2″, where R2″is C1 to C6 linear or branched alkylene substituted with a substituent selected from the group consisting of hydrogen, phenyl, alkoxy, alkoxy substituted with phenyl, carboxylic acid or the alkyl esters thereof, carbamoyloxy alkyl, substituted carbamoyloxy alkyl and amino or 5-(2-alkanoyl) tetrazole; R3, R4, R5 and R6 are the same or different and are C1 to C6 linear or branched alkyl, C1 to C6 linear or branched alkoxy, phenoxy or phenoxy substituted with one or more C1 to C6 linear or branched alkyl. The compounds display melatonin antagonist and are antiproliferative agents.
대표청구항
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Compounds of the formula [Figure] where R is hydrogen or C1 to C6 linear or branched alkylene substituted with phenyl; R1 is benzyl, or naphthylmethyl; R2 is the group －(CH2)m－NHR2′, where m is 1 to 3 and R2′is phenyl sulfonyl, the phenyl group optionally substituted with alkyl, or －C(O)－R2″, where
Compounds of the formula [Figure] where R is hydrogen or C1 to C6 linear or branched alkylene substituted with phenyl; R1 is benzyl, or naphthylmethyl; R2 is the group －(CH2)m－NHR2′, where m is 1 to 3 and R2′is phenyl sulfonyl, the phenyl group optionally substituted with alkyl, or －C(O)－R2″, where R2″is C1 to C6 linear or branched alkylene substituted with a substituent selected from the group consisting of hydrogen, phenyl, alkoxy, alkoxy substituted with phenyl, carboxylic acid or the alkyl esters thereof, carbamoyloxy alkyl, carbamoyloxy alkyl substituted with phenyl or phenyl substituted with at least one substituent selected from the group consisting halo, amino, nitro, hydroxy, alkyl, alkoxy, and haloalkyl, and amino or 5-(2-alkanoyl) tetrazole; R3, R4, R5 and R6 are the same or different and are hydrogen, C1 to C6 linear or branched alkyl, C1 to C6 linear or branched alkoxy, phenoxy or phenoxy substituted with one or more C1 to C6 linear or branched alkyl.
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