IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0737077
(1991-07-29)
|
발명자
/ 주소 |
- Tempesta Michael S. (Moss Beach CA)
|
출원인 / 주소 |
- Shaman Pharmaceuticals, Inc. (San Carlos CA 02)
|
인용정보 |
피인용 횟수 :
31 인용 특허 :
0 |
초록
▼
The present invention provides for proanthocyanidin polymers with significant antiviral activity. The proanthocyanidin polymers can be chemically synthesized or can be isolated from a Croton or a Calophyllum plant species. The present invention encompasses methods of using proanthocyanidin polymers
The present invention provides for proanthocyanidin polymers with significant antiviral activity. The proanthocyanidin polymers can be chemically synthesized or can be isolated from a Croton or a Calophyllum plant species. The present invention encompasses methods of using proanthocyanidin polymers in treating warm-blooded animals, including humans, infected with paramyxovaridae such as respiratory syncytial virus, orthomyxovaridae such as influenza A, B and C, and herpes viruses such as Herpes Simplex virus.
대표청구항
▼
A proanthocyanidin polymer composition, characterized by: (a) the capability of dissolving in water and/or aqueous solution; (b) the capability of exerting a pronounced antiviral effect as demonstrated in in vitro assays for antiviral activity against respiratory syncytial virus, types A and B; para
A proanthocyanidin polymer composition, characterized by: (a) the capability of dissolving in water and/or aqueous solution; (b) the capability of exerting a pronounced antiviral effect as demonstrated in in vitro assays for antiviral activity against respiratory syncytial virus, types A and B; parainfluenza virus, types 1 and 3; influenza virus, types A and B; and as demonstrated in in vivo tests for antiviral activity against respiratory syncytial virus; influenza virus, type A; parainfluenza virus, type 3; and herpes simplex virus, type 2; (c) comprising a proanthocyanidin polymer having a structure comprising flavonoid units selected from the group consisting of catechins, epicatechins, gallocatechins, galloepicatechins and combinations thereof; and (d) 13C NMR spectra having peak positions at d154.2, 145.1, 143.7, 132.8, 131.2, 130.3, 120.9-118.6 (series of broad peaks), 116.1, 115.4, 114.3, 108.0, 106.3, 96.6, 95.3, 81.8, 77.6, 75.3, 72.6, 1.5, 65.6, 37.1, 35.3, and 27.7.
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