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특허 상세정보

Fibrin sealant delivery method

국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A61M-031/00    A61M-035/00   
미국특허분류(USC) 604/49 ; 604/54 ; 604/56 ; 604/290
출원번호 US-0460379 (1990-01-03)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 171  인용 특허 : 0
초록

The present invention relates to a method for the formulation of fibrin sealant in a single delivery system. The method involves mixing a fibrinogen/Factor XIII precipitate solution with thrombin under conditions such that thrombin clotting activity is inhibited and said mixture is applied to a body site under conditions which activate the thrombin to convert fibrinogen into fibrin sealant. A single device, syringe or container, can be used to apply the fibrin sealant formulation.

대표
청구항

A method of effecting the formation of fibrin sealant at a body site comprising: i) mixing, in a container means, an aqueous solution comprising fibrinogen, Factor XIII and mature thrombin under conditions such that thrombin clotting activity is inhibited; and ii) applying a preparation resulting from step (i) to said body site under conditions such that thrombin clotting activity is restored and said fibrin sealant is formed; wherein step (i) is carried out at a pH of less than 5.5, whereby thrombin clotting activity is inhibited.

이 특허를 인용한 특허 피인용횟수: 171

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