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특허 상세정보

MyON담기
내보내기 페이스북 공유 카카오톡 공유

Ice-mediated introduction of substances into biological material

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) C12N-015/87    C12N-015/89    C12N-015/90   
미국특허분류(USC) 435/1723 ; 435/1721 ; 435/2404 ; 935/52
출원번호 US-0863356 (1992-03-31)
발명자 / 주소
인용정보 피인용 횟수 : 67  인용 특허 : 0
초록
▼

Methods and apparatus for the introduction of foreign substances, such as recombinant DNA, into living cell interiors is disclosed. The desired substance to be introduced is dissolved or suspended in water or another suitable liquid to form a solution which is then nebulized and frozen to produce ice particles. These ice particles are accelerated toward and impact upon a target tissue where some of the particles impregnate at least some cells in the target tissue without killing the cells. Following impregnation, the ice particles melt, leaving behind th...

대표
청구항

A method for genetically transforming cells comprising the steps of: a) preparing ice particles of a solution of copies of a DNA sequence suitable for expression; b) providing cells as a target; c) physically accelerating the ice particles containing the DNA sequence toward the cells in such a manner that at least some of the ice particles lodge in a non-lethal manner in the interior of at least some of the cells and melt to release the DNA; and d) confirming the existence of the DNA in the cells.

이 특허를 인용한 특허 피인용횟수: 67

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