[특허]Multi-optical detection system

Multi-optical detection system 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/53 G01N-021/01
출원번호	US-0627027 (1990-12-13)
발명자 / 주소	Ribi Hans O. (San Mateo CA) Guion Todd A. (Burlingame CA) Murdoch Joseph R. (Burlingame CA) Scott John C. (Los Gatos CA) Pan Victor (Burlingame CA) Choate Glenda L. (Belmont CA)
출원인 / 주소	Biocircuits Corporation (Sunnyvale CA 02)
인용정보	피인용 횟수 : 69 인용 특허 : 0

초록 ▼

Apparatus and methods are provided for the detection of analytes. A polyunsaturated polymerized lipid layer is employed, which is anisotropic, has a member of a specific binding pair bound to an end of the lipids, and whose optical characteristics are modified upon complex formation between the specific binding pair member and its complementary member. By providing for polarized light, linear and/or circular, one can detect the presence of complex formation by the change in the optical characteristics of the film. Polarizers, analyzers, and wave plates are employed for providing for a light signal which can be analyzed and related to the presence of an analyte in a sample.

대표청구항 ▼

A method for determining the presence of an analyte in a sample, employing a detection system comprising a polymerized polyunsaturated lipid oriented crystalline layer having extended conjugated aliphatic unsaturation and groups proximal to one surface of said layer, wherein said groups are one member of a specific binding pair and said analyte is a member of said specific binding pair, wherein said surface has a sample region and a control region, wherein a value is obtained for at least one of the intensity, orientation and amplitude of light emanating from said regions of said polyunsaturated lipid layer surface, said method comprising: contacting said sample region of said lipid layer surface with said sample in a liquid assay medium, and contacting said control region of said lipid layer with said liquid assay medium, and contacting both said regions with any additional reagents required to change the optical characteristics of said layer in relation to the presence of said analyte; substantially drying each of said regions; irradiating said regions with collimated light; determining a sample and control value of at least one of the intensity, orientation and amplitude of light emanating from said regions; and comparing the difference in values from said sample region of said polyunsaturated lipid layer surface before said contacting and after said drying, with the difference in values from said control region of said polyunsaturated lipid layer surface before said contacting and after said drying, as a determination of the presence of said analyte in said sample.

이 특허를 인용한 특허 (69)

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Grenon, Stephen M.; Korb, Donald R., Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography.
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Grenon, Stephen M.; Korb, Donald R., Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography.
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Grenon, Stephen M.; Korb, Donald R., Full-eye illumination ocular surface imaging of an ocular tear film for determining tear film thickness and/or providing ocular topography.
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Korb, Donald R.; Weber, William L.; Chinnock, Randal B.; Gravely, Benjamin T.; Grenon, Stephen M., Ocular surface interferometery (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film.
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Korb, Donald R.; Weber, William L.; Chinnock, Randal B.; Gravely, Benjamin T.; Grenon, Stephen M., Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film.
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Korb, Donald R.; Weber, William L.; Chinnock, Randal B.; Gravely, Benjamin T.; Grenon, Stephen M., Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film.
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Korb, Donald R.; Weber, William L.; Chinnock, Randal B.; Gravely, Benjamin T.; Grenon, Stephen M., Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film.
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Korb, Donald R.; Weber, William L.; Chinnock, Randal B.; Gravely, Benjamin T.; Grenon, Stephen M., Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film.
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Korb, Donald R.; Weber, William L.; Chinnock, Randal B.; Gravely, Benjamin T.; Grenon, Stephen M., Ocular surface interferometry (OSI) devices and systems for imaging, processing, and/or displaying an ocular tear film.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Multi-optical detection system 원문보기

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Multi-optical detection system 원문보기

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이 특허를 인용한 특허 (69)

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