초록 ▼

A stabilized aqueous dentifrice composition capable of producing or, in the presence of saliva, leading to the production of antimicrobially effective concentrations of hypothiocyanite ions (OSCN－) are herein described. The composition contains both an oxidoreductase enzyme and its specific substrat

A stabilized aqueous dentifrice composition capable of producing or, in the presence of saliva, leading to the production of antimicrobially effective concentrations of hypothiocyanite ions (OSCN－) are herein described. The composition contains both an oxidoreductase enzyme and its specific substrate, for the purpose of producing hydrogen peroxide of at least the minimum effective concentration. The aqueous dentifrice compositions of the present invention can be stabilized against premature enzyme/substrate interaction by controlling the level of dissolved oxygen in the aqueous dentifrice carrier. Optionally, a peroxidase enzyme may be included to act upon the aforementioned hydrogen peroxide, thereby oxidizing salivary thiocyanate ions to produce the antimicrobial concentrations of hypothiocyanite ions (OSCN－). Optionally, thiocyanate ions may also be included in the compositions of this invention in an amount sufficient, together with the other inventive ingredients, to produce in excess of about 100 micromoles/liter/minute of hypothiocyanite ions during use.

대표청구항 ▼

Method of making an enzyme containing antimicrobial composition comprising the steps of: providing a biologically acceptable carrier to a mixing chamber; adding to said carrier oxidoreductase enzyme and oxidoreductase enzyme substrate which form hydrogen peroxide when reacted together, said enzyme a

Method of making an enzyme containing antimicrobial composition comprising the steps of: providing a biologically acceptable carrier to a mixing chamber; adding to said carrier oxidoreductase enzyme and oxidoreductase enzyme substrate which form hydrogen peroxide when reacted together, said enzyme and substrate being provided in sufficient amount such that said hydrogen peroxide is formed at a rate from about 0.10 millimoles per liter per minute to about 10.00 millimoles per minute; and limiting the amount of oxygen in said antimicrobial composition to a concentration of less than about 3.2 parts per million (ppm) by either evacuating or partially evacuating the mixing chamber or by replacing all or substantially all of the oxygen present in the mixing chamber with an inert gas.