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Method and kit for performing nucleic acid hybridization assays

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/70
  • C12Q-001/68
  • C07H-021/04
출원번호 US-0798027 (1991-11-20)
발명자 / 주소
  • Snitman David L. (Boulder CO) Stroupe Stephen D. (Libertyville IL)
출원인 / 주소
  • Amgen (Thousand Oaks CA 02) Abbott Laboratories (North Chicago IL 02)
인용정보 피인용 횟수 : 21  인용 특허 : 12

초록

A method and a kit for the isolation and quantitative detection of a selected target nucleic acid sequence from solution employing two probes. A first probe is complementary to one portion of the target and is covalently attached to a first complexing agent (e.g., either an antigen or an antibody).

대표청구항

A method for the isolation of a selected target nucleic acid sequence from a solution comprising the steps of: (a) hybridizing a target sequence to a first single-stranded nucleic acid probe having a sequence complementary to a first portion of the target nucleic acid sequence, the first probe being

이 특허에 인용된 특허 (12)

  1. Paau, Alan; Platt, Steven G.; Sequeira, Luis, Assay method and probe for polynucleotide sequences.
  2. Ranki Tuula M. (Espoo FIX) Soderlund Hans E. (Espoo FIX), Detection of microbial nucleic acids by a one-step sandwich hybridization test.
  3. Zuk Robert F. (Mountain View CA) Ullman Edwin F. (Atherton CA), Fluorescent scavenger particle immunoassay.
  4. Englehardt Dean L. (New York NY) Rabbani Elazar (New York NY), Hybridization method for the detection of genetic material.
  5. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
  6. Neurath A. Robert (New York NY) Strick Nathan (Far Rockaway NY), Labeled anti-hapten antibodies and their use as a universal reagent for solid phase radio- and/or enzyme-immunoassays.
  7. Kourilsky Philippe (Paris FRX) Avrameas Stratis (Paris FRX) Cami nee Contamine Brigitte (Paris FRX) Guesdon Jean-Luc (Paris FRX), Method of detecting and characterizing a nucleic acid or reactant for the application of this method.
  8. Albarella James P. (Elkhart IN) Anderson Leslie H. D. (Encinitas CA), Nucleic acid hybridization assay employing antibodies to intercalation complexes.
  9. Giese Roger W. (56 Oakland Ave. Quincy MA 02170), Process for applying multiple layers of a protein and a ligand extender to a surface and to the multiple-layer system.
  10. Adachi Masakazu (Gunma JPX), Process for determining tumor-associated glycolinkage.
  11. Sheldon ; III Edward L. (Oakland CA) Levenson Corey H. (Oakland CA) Mullis Kary B. (Oakland CA) Rapoport Henry (Berkeley CA), Process for labeling nucleic acids using psoralen derivatives.
  12. Falkow Stanley (Seattle WA) Moseley Stephen L. (Kirkland WA), Specific DNA probes in diagnostic microbiology.

이 특허를 인용한 특허 (21)

  1. Pegg Randall Kevin (5085 First Coast Hwy. Amelia Island FL 32034) Saunders Mary Starnes (Rte. 3 Box 106-1 Monticello FL 32344), Assay preparation containing capture and detection polynucleotides covalently bound to substrates with a heterobifunctio.
  2. Arnold ; Jr. Lyle J. ; Nelson Norman C., Compositions for homogenous protection assay.
  3. Lucas Joe N. ; Straume Tore ; Bogen Kenneth T., Detection and isolation of nucleic acid sequences using a bifunctional hybridization probe.
  4. Lucas Joe N. (San Ramon CA) Straume Tore (Tracy CA) Bogen Kenneth T. (Walnut Creek CA), Detection and isolation of nucleic acid sequences using competitive hybridization probes.
  5. Usui Mitsugu,JPX, Gene amplifying method.
  6. Lucas Joe N. ; Straume Tore ; Bogen Kenneth T., Identification of random nucleic acid sequence aberrations using dual capture probes which hybridize to different chrom.
  7. Lucas Joe N. ; Straume Tore ; Bogen Kenneth T., Kit for detecting nucleic acid sequences using competitive hybridization probes.
  8. Oka Takanori,JPX, Method and nucleic acid-concentratiing assay kit for concentrating mutant nucleic acid.
  9. Lucas Joe N. ; Straume Tore ; Bogen Kenneth T., Method for identifying and quantifying nucleic acid sequence aberrations.
  10. Bergmeyer Lynn (Rochester NY) Cummins Thomas J. (Rochester NY), Method, test element and test kit for semi-quantitative detection of target nucleic acid.
  11. Pollner, Reinhold B.; Becker, Michael M.; Majlessi, Mehrdad R., Methods of nucleic acid target capture.
  12. Niemeyer, Christof M.; Cantor, Charles R.; Sano, Takeshi; Smith, Cassandra L., Nucleic acid directed immobilization arrays and methods of assembly.
  13. Cheronis,John C.; Trollinger,David, Quantitative assay for low abundance molecules.
  14. Mandrand Bernard,FRX ; Cros Philippe,FRX ; Delair Thierry,FRX ; Charles Marie-Helene,FRX ; Erout Marie-Noelle,FRX ; Pichot Christian,FRX, Reagent and method for the detection of a nucleotide sequence with signal amplification.
  15. Billing Medel,Patricia A.; Cohen,Maurice; Colpitts,Tracey L.; Friedman,Paula N.; Gordon,Julian; Granados,Edward N.; Hodges,Steven C.; Klass,Michael R.; Kratochvil,Jon D.; Roberts Rapp,Lisa; Russell,John C.; Stroupe,Stephen D., Reagents and methods useful for detecting diseases of the breast.
  16. Cantor Charles R. ; Niemeyer Christof M.,DEX ; Smith Cassandra L. ; Sano Takeshi ; Hnatowich Donald J. ; Rusckowski Mary, Self-assembling multimeric nucleic acid constructs.
  17. Kozwich, Diane L.; Gerdes, John C., Self-contained device integrating nucleic acid extraction, amplification and detection.
  18. Mark L. Collins ; Donald N. Halbert ; Walter King ; Jonathan M. Lawrie, Target and background capture methods with amplification for affinity assays.
  19. Weisburg William G. ; Shaw Jay H. ; Becker Michael M. ; Majlessi Mehrdad, Two-step hybridization and capture of a polynucleotide.
  20. Weisburg William G. ; Shaw Jay H. ; Becker Michael M. ; Majlessi Mehrdad, Two-step hybridization and capture of a polynucleotide.
  21. Weisburg, William G.; Shaw, Jay H.; Becker, Michael M.; Majlessi, Mehrdad R.; Brentano, Steven T.; Nunomura, Kiyotada, Two-step hybridization and capture of a polynucleotide.
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