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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0795976 (1991-11-22) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 779 인용 특허 : 0 |
The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expanda
The invention features a catheter and methods for delivering drug to tissue at a desired location of the wall of a body lumen. The catheter is constructed for insertion in a body lumen and has a catheter shaft and an expandable portion mounted on the catheter shaft. The expandable portion is expandable to a controlled pressure to fill the cross-section of the body lumen and press against the wall of the body lumen. In one embodiment, at least a portion of the exterior surface of the expandable portion is defined by a coating of a tenaciously adhered swellable hydrogel polymer. Incorporated in the hydrogel polymer is an aqueous solution of a preselected drug to be delivered to the tissue or plaque. The hydrogel polymer and drug are selected to allow rapid release of a desired dosage of the drug from the hydrogel polymer coating during compression of the hydrogel polymer coating against the wall of the lumen when the expandable portion is expanded. In other embodiments the polymer is released from the expandable portion in response to pressure, to coat the wall of the body lumen.
A method for rapidly delivering a dose of a preselected aqueous-mobile drug into tissue or occlusive formation at a desired location of the wall of a vascular lumen, comprising: providing a catheter constructed for insertion into a vascular lumen having a catheter shaft and an expandable portion mou
A method for rapidly delivering a dose of a preselected aqueous-mobile drug into tissue or occlusive formation at a desired location of the wall of a vascular lumen, comprising: providing a catheter constructed for insertion into a vascular lumen having a catheter shaft and an expandable portion mounted on said catheter shaft, said expandable portion being expandable in response to controlled inflation pressure to fill the cross-section of the vascular lumen and engage the tissue or occlusive formation of said vascular lumen, at least a portion of the exterior surface of the expandable portion being defined by a coating of a tenaciously adhered swellable hydrogel polymer, having said dose of said aqueous-mobile drug incorporated therein said hydrogel polymer selected to cause the coating to reach a characteristic swollen state of a thickness a number of times thicker than the thickness of the coating in its dry state as a result of absorption of aqueous fluid, and, when in said swollen state, said coating having characteristic compressibility, in response to compressive pressure within said expandable portion elevated above said inflation pressure, to squeeze the coating against said tissue or occlusive formation sufficiently to immediately, substantially, reduce the coating thickness, and force a substantial portion of said dose of said aqueous-mobile drug into said tissue or occlusive formation, preparing said expandable portion by introducing said drug to said hydrogen polymer coating, swelling said hydrogel polymer coating, positioning said expandable portion in said lumen at the point of desired drug application, expanding said expandable portion to cause immediate delivery of said drug by compression of said hydrogel polymer coating against the wall of said body lumen or said occlusive formation for a brief interval, during which said dose of said preselected drug is rapidly squeezed from said hydrogel coating and delivered to said tissue; deflating said expandable portion, and removing said catheter from said body lumen.
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