초록 ▼

Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection of the proliferation of T cells in response to in vitro exposure to a protein expression product of an activated oncogene or cancer-related gene associated with a malignancy, or detection of immunocomplexes

Methods for the detection, monitoring and treatment of malignancies are disclosed. Detection of the proliferation of T cells in response to in vitro exposure to a protein expression product of an activated oncogene or cancer-related gene associated with a malignancy, or detection of immunocomplexes formed between the protein expression product and antibodies in body fluid, allows the diagnosis of the presence of a malignancy. The present invention also discloses methods and compositions for treating a malignancy.

대표청구항 ▼

1. A method for the detection of a malignancy in a warm-blooded animal, wherein an activated oncogene or cancer-related gene is associated with the malignancy, wherein said activated oncogene is ras or bcr-abl, comprising the steps of: (a) isolating T cells from the warm-blooded animal; (b) incu

1. A method for the detection of a malignancy in a warm-blooded animal, wherein an activated oncogene or cancer-related gene is associated with the malignancy, wherein said activated oncogene is ras or bcr-abl, comprising the steps of: (a) isolating T cells from the warm-blooded animal; (b) incubating the T cells with at least one protein expression product of an activated oncogene associated with the malignancy, wherein said activated oncogene is ras or bcr-abl; and (c) detecting the presence or absence of proliferation of the T cells, thereby determining the presence or absence of the malignancy. 2. The method of claim 1 wherein the step of detecting comprises measuring the rate of DNA synthesis of t he T cells.