초록 ▼

Hot-melt silicone pressure sensitive adhesive compositions containing organic waxes, methods of using the compositions and devices made using the compositions are disclosed. The hot-melt silicone pressure sensitive adhesive compositions include a mixture of (i) a silicate resin, (ii) a silicone flui

Hot-melt silicone pressure sensitive adhesive compositions containing organic waxes, methods of using the compositions and devices made using the compositions are disclosed. The hot-melt silicone pressure sensitive adhesive compositions include a mixture of (i) a silicate resin, (ii) a silicone fluid, and (iii) an organic wax having a melting point of between 30°C. and 150°C. The organic wax decreases dynamic viscosity of the adhesive at temperatures equal to or below about 200°C.

대표청구항 ▼

A matrix transdermal drug delivery device for a bioactive agent, comprising: (a) a backing substrate; (b) an adhesive matrix atop at least portions of said backing substrate, said adhesive matrix formed of a non-flammable, hot-melt, silicone pressure sensitive adhesive composition having tackiness a

A matrix transdermal drug delivery device for a bioactive agent, comprising: (a) a backing substrate; (b) an adhesive matrix atop at least portions of said backing substrate, said adhesive matrix formed of a non-flammable, hot-melt, silicone pressure sensitive adhesive composition having tackiness and adhesiveness containing (i) between about 30 and about 70 percent by weight of a benzene-soluble resinous copolymer containing silicon-bonded hydroxyl radicals and consisting essentially of triorganosiloxy units of the formula R3SiO½and tetra functional siloxy units of the formula SiO4/2 in a ratio of about 0.6 to 0.9 triorganosiloxy units for each tetra functional siloxy unit present in the copolymer, wherein each R is a monovalent organic radical independently selected from the group consisting of hydrocarbon radicals of from 1 to 6 inclusive carbon atoms; (ii) between about 22 and about 60 percent by weight of a polydimethylsiloxane fluid; and (iii) between about 1.0 and about 25 percent by weight of an organic wax, all weight percents being based on total composition weight, said wax having a melting point of between about 30°C. and about 150°C., and said organic wax decreasing the dynamic viscosity of the resultant hot-melt silicone pressure sensitive adhesive at temperatures ranging up to about 200°C., and said silicone pressure sensitive adhesive composition including ingredients selected from the group consisting of drugs, excipients, co-solvents, enhancers, and mixtures thereof where the silicone pressure sensitive adhesive composition is compatible with said drugs, excipients, co-solvents and enhancers wherein the silicone pressure sensitive adhesive composition has a tack value between about 50 and 800 g/cm2 measured using a probe tack tester at a speed of 0.5 cm/second with a 0.5 second dwell time; and (c) a release liner contacted on the adhesive matrix.