[특허]Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same

Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61M-005/00 A61M-037/00 A61B-019/00
출원번호	US-0031683 (1993-03-15)
발명자 / 주소	Harris Dale C. (Fairland IN)
출원인 / 주소	Eli Lilly and Company (Indianapolis IN 02)
인용정보	피인용 횟수 : 61 인용 특허 : 0

초록 ▼

A cartridge assembly for holding a lyophilized product, forming a disposable portion of a pen injector includes a cylindrical glass cartridge adapted to receive the product, a closure cap, a cartridge case, and a plunger mechanism. The closure cap is adapted to retain an elastomeric disc seal during lyophilization and includes diametrically opposed ledges. The closure cap and seal are adapted to cover a neck portion of the ampule, the neck portion having on its end a radially extending circumferential flange. The ledges of the closure cap and the flange of the neck portion allow the closure cap to remain open during lyophilization, oxygen purge and nitrogen overlay. An oval-shaped indentation formed on the inside of the closure cap aids in snapping the closure cap about the flange without crimping to retain the closure cap underneath the flange. Reconstitution of the lyophilized drug is accomplished without foaming by use of an obliquely angled connector which causes the diluent to indirectly impinge on the drug. The injection pen and cartridge assembly cooperate such that the length of travel of the plunger rod during retraction is less than the axial length of a recess in the rod tip.

대표청구항 ▼

A method of lyophilizing and sealing an injectionable product within a cartridge, the method comprising the steps of: providing an elongate cartridge having on a first end thereof a shoulder, a rim defining a first opening and having a circumferential radially outwardly extending flange adjacent said first opening, and a neck disposed axially between said flange and shoulder, said neck having a diameter smaller than said flange and shoulder, said cartridge including a second opening on a second end thereof distal said first opening; inserting a plunger in said second opening; providing a cap having a cylindrical portion and a seal, said cylindrical portion including an open bottom receivable over said neck, said cap including a top having an opening therein for receipt of a needle therethrough, at least one vent circumferentially disposed in said cap, and at least two deformable ledges on said cap extending radially inwardly from said cylindrical portion axially below said vent, said seal being axially disposed between said vent and said top so as to block said top opening; inserting the product to be lyophilized into said cartridge; placing said cap onto said cartridge such that said deformable ledges rest upon said flange and said vent is in fluid communication with said cartridge first opening; placing said cartridge with said cap in a lyophilizing chamber; lyophilizing the product; and closing said cap by exerting a downward pressure upon said cap such that said deformable ledges yieldably snap around said flange and into said neck to be lockingly retained therein, said vent is blocked from communication with said cartridge first opening, and said seal is pressed into sealing engagement with said rim by downward pressure exerted by said top thereby providing an air impermeable barrier between said top opening and said cartridge first opening.

이 특허를 인용한 특허 (61)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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Cartridge assembly for a lyophilized compound forming a disposable portion of an injector pen and method for same 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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이 특허를 인용한 특허 (61)

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