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Growth hormone antagonists 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-013/00
  • C12P-021/06
  • A61K-037/36
출원번호 US-0878703 (1992-05-04)
발명자 / 주소
  • Kopchick John J. (Athens OH) Chen Wen Y. (Athens OH)
출원인 / 주소
  • Ohio University (Athens OH 02)
인용정보 피인용 횟수 : 358  인용 특허 : 0

초록 ▼

The present invention relates to antagonists of vertebrate growth hormones obtained by mutation of the third alpha helix of such proteins (especially bovine or human GHs). These mutants have growth inhibitory or other GH-antagonizing effects. These novel hormones may be administered exogenously to a

대표청구항

A vertebrate growth hormone in which the amino acid position in said vertebrate growth hormone corresponding to amino acid Gly 119 of bovine growth hormone is deleted or substituted with an amino acid, said vertebrate growth hormone having growth hormone antagonist activity.

이 특허를 인용한 특허 (358)

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  320. Perona Abellon, Rosario; Machado Pinilla, Rosario; Sastre Garzon, Leandro; Sanchez Perez, Isabel; Murguia Ibanez, Jose Ramon, Sequence of nucleotides and peptides GSE 24.2 of dyskerin, which can induce telomerase activity, method for obtaining same, therapeutic compositions and applications thereof.
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  321. Beyaert,Rudi; Janssens,Sophie, Splice variant of MyD88 and uses thereof.
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