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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0771483 (1991-10-04) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 275 인용 특허 : 0 |
The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive el
The present invention relates to an vitro device for the removal of ionized substances from a membrane sample without mechanical penetration, which device comprises: (a) a positive electrode; (b) a negative electrode, and (c) electrical insulation between subpart (a) and (b), wherein the positive electrode, and the negative electrode, and electrical insulation are positioned on the same side of the membrane sample. The present invention also relates to a device for the removal of or delivery of ionized substances to a mammal through intact skin or mucosal membrane without mechanical penetration, which device comprises: (a) a positive electrode, (b) a negative electrode, and (c) an electrically insulating material between subpart (a) and (b), wherein the positive electrode, negative electrode and insulating material are physically positioned so that each present a common surface of the device for contact with the same surface of the skin or mucosal membrane of the mammal. The present invention also relates to the use of iontophoresis to determine the level of a charged molecule in a living mammal, and with the use of a feedback mechanism, administer appropriate levels of therapeutic substances.
An iontophoretic diffusion cell device for the in vivo non-invasive removal of at least one charged or non-charged organic substance selected from glucose, a glucose species, a metabolite of glucose or combinations thereof, which organic substance is capable of migrating under the influence of an el
An iontophoretic diffusion cell device for the in vivo non-invasive removal of at least one charged or non-charged organic substance selected from glucose, a glucose species, a metabolite of glucose or combinations thereof, which organic substance is capable of migrating under the influence of an electrical current and migrates within a membrane surface, underlying tissue and circulating blood and migrates through the surface of intact skin or mucosa of a mammal into collection means for collecting the organic substance at the positive electrode, the negative electrode or a combination thereof, said device comprising: (a) a positive electrode having an electrode surface which contacts the skin surface, (b) a negative electrode having an electrode surface which contacts a different portion of the skin surface, (c) electrically insulating means located between the positive electrode and negative electrode for electrical insulation between the electrodes and for monitoring current leakage between the positive and negative electrode, and (d) electrically insulating material of construction in the shape of walls and edges to physically separate the positive electrode, the negative electrode and the electrically insulating means from each other, wherein the positive electrode, negative electrode and insulating means are physically configured such that each present a single common surface of wall edges of the device for contact with the same side of the skin surface or mucosal surface of the mammal, and wherein either the positive electrode or the negative electrode or combinations thereof have reservoir collection means for collecting the removed charged or non-charged organic substance.
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