Liquid chromatography stationary phases with reduced silanol interactions
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IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07F-007/02
C08G-077/12
출원번호
US-0916775
(1992-07-17)
발명자
/ 주소
Neue Uwe D. (Ashland MA) Niederlaender Carsten L. (Milford MA) Petersen John S. (Acton MA)
출원인 / 주소
Millipore Corporation (Bedford MA 02)
인용정보
피인용 횟수 :
37인용 특허 :
0
초록▼
Novel carbamate compounds, novel silylcarbamate compounds and novel reversed phase materials comprising a silica substrate modified with a modified novel silylcarbamate compound are disclosed which may, for example, be used as stationary phases for liquid chromatography applications. Attached to the
Novel carbamate compounds, novel silylcarbamate compounds and novel reversed phase materials comprising a silica substrate modified with a modified novel silylcarbamate compound are disclosed which may, for example, be used as stationary phases for liquid chromatography applications. Attached to the carbamate group are several reversed or normal phase producing groups such as cyanoalkyl, tertiary butyl, dibutyl, octyl, dodecyl, tetradecyl, octadecyl or benzyl. The new stationary phases may be endcapped with a short chain alkyl silane. One particular advantage of these stationary phases is decreased interaction with basic samples due to shielding of the unreacted silanol groups on the silica surface. The new phases are particularly useful in the chromatographic analysis of basic samples or more generally for samples having an undesirable interaction with the unmodified silanols.
대표청구항▼
A surface modified silica of the formula III, [Figure] FORMULA III wherein l, m, o, r, s, t and u are 0 or 1, n is 0,1, 2 or 3 p is 0,1,2,3 or 4 and q is an integer from 0 to 19; R3 is selected from the group consisting of hydrogen, alkyl, cyano and phenyl; and R4 and R6 are selected from the group
A surface modified silica of the formula III, [Figure] FORMULA III wherein l, m, o, r, s, t and u are 0 or 1, n is 0,1, 2 or 3 p is 0,1,2,3 or 4 and q is an integer from 0 to 19; R3 is selected from the group consisting of hydrogen, alkyl, cyano and phenyl; and R4 and R6 are selected from the group consisting of oxygen, methyl and ethyl.
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