[특허]Process for the obtention of a biological adhesive made of concentrated coagulation factors by “salting-out”

Process for the obtention of a biological adhesive made of concentrated coagulation factors by “salting-out” 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C07K-003/24 C07K-015/06 A61K-037/02
출원번호	US-0021302 (1993-02-23)
발명자 / 주소	Bui-Khac Trung (Montreal CAX) Lavoie Lise (St-Eustache CAX) Michel St Picq Dominique (Ste-Genevive CAX)
출원인 / 주소	Haemacure-Biotech, Inc. (Pointe-Claire CAX 03)
인용정보	피인용 횟수 : 93 인용 특허 : 0

초록 ▼

The present invention relates to a process of making a concentrate of coagulation proteins starting with whole human or animal plasma. This concentrate is used as a biological adhesive when extemporaneously mixed to thrombin. The concentrated proteins include mostly fibrinogen, fibrin stabilizing factor (factor XIII) and fibronectin. The claimed process has the advantage of being short of execution while providing an excellent yield of coagulable proteins. No protease inhibitor has to be added during the process. The process involves steps of separation by “salting-out”in presence of amino-6 hexanoic acid which prevents co-precipitation of plasminogen with the desired coagulable proteins. The proteins so obtained are very stable after reconstitution in water for at least 24 hours at room or body temperature. After mixing with thrombin and calcium, the adhesive shows excellent strength and biocompatibility.

대표청구항 ▼

A method for the preparation of a protein concentrate coagulable by thrombin, which protein concentrate consists essentially of fibrinogen, endogenous Factor XIII and fibronectin, characterized in that it comprises the following steps: (a) a first precipitation effected on whole plasma proteins by the addition of a salt in a sufficient quantity to achieve a salting out effect and a pH of 7.5 to 8.5, whereby fibrinogen, Factor XIII and fibronectin are selectively precipitated to provide precipitated proteins, said selective precipitation being conducted at 0°to 4°C., in the presence of a concentration of at least 50 mM of amino-6 hexanoic acid; (b) a first solubilization of the precipitated proteins in the presence of 0.2 to 0.3 g of L-Histidine per gram of proteins to form a solution containing the proteins; (c) a viral deactivation step of the solution obtained in step (b) in a solvent-detergent solution; (d) a second precipitation by the same salt as in step (a) at the same temperature, in the presence of the same concentration of amino-6 hexanoic acid to form a second precipitate; (e) a washing of the second precipitate to bring the washed second precipitate to a neutral pH; (f) a second solubilization of the washed second precipitate in the presence of 0.2 to 0.3 g of L-Histidine per gram of proteins; (g) an addition of 50% saccharose with respect to the quantity of proteins obtained by step (f) to form a solution; (h) a sterile filtration of the solution obtained in step (g) to form a filtered solution; (i) an aliquoting of the filtered solution of step (h) in sterile bottles; and (j) a lyophilisation of the solution aliquoted in step (i) to provide a lyophilized concentrate.

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Process for the obtention of a biological adhesive made of concentrated coagulation factors by “salting-out” 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

이 특허를 인용한 특허 (93)

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연합인증

Process for the obtention of a biological adhesive made of concentrated coagulation factors by “salting-out” 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

전체(0) 논문(0) 특허(0) 보고서(0)

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이 특허를 인용한 특허 (93)

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