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Methods for the synthesis of phosphonate esters 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07F-009/09
출원번호 US-0119700 (1993-09-09)
발명자 / 주소
  • Campbell David A. (Redwood Shores CA)
출원인 / 주소
  • Affymax Technologies, N.V. (Caracao ANX 03)
인용정보 피인용 횟수 : 64  인용 특허 : 0

초록 ▼

Phsophonate esters can be synthesized in high yields by condensations of alcohols with methyl phosphonates followed by selective demethylation. The reaction is general, relativly insensitive to steric constraints of hindered phosphonic acids, and can also be carried out on a solid support to synthes

대표청구항 ▼

A method for preparing a phosphonic acid monoester from a phosphonate with a structure: [Figure] wherein R1 is selected from the group consisting of alkyl, aryl, Substituted alkyl, substituted aryl, heteroaryl, alkylaryl, and aminoalkyl, and R2 is selected from the group consisting of methyl, ethyl,

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